Treatment of Major Depression

Ketamine attenuates habenula activity in response to aversive outcomes during Pavlovian learning

This study shows ketamine reduces habenula activity during aversive learning in humans, supporting preclinical findings on its antidepressant mechanisms.

Distinct depressive-like behavioural phenotypes in mice exhibit unique patterns of transcriptional perturbations across habenular cell subtypes

The paper identifies distinct transcriptional changes in habenular cell subtypes associated with different depressive-like behavioural phenotypes in mice.

Behavioral and Pharmacological Validation of the Differential Reinforcement of Low-Rate Behavior Paradigm in Non-Human Primates

This study validates the Differential Reinforcement of Low-Rate Behavior (DRL) task in non-human primates as a tool for assessing antidepressant efficacy and side effects.

Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine

This study shows that microglial BDNF is essential for ketamine's antidepressant and synaptogenic effects in the prefrontal cortex.

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex

This paper performs two meta-analyses of transcriptional data from rodent brain regions to identify shared gene expression changes across antidepressant categories.

Effects of SSRIs on the spatial transcriptome of dorsal raphe serotonin neurons

This study examines how SSRIs affect the spatial transcriptome of serotonin neurons in the dorsal raphe nucleus, identifying gene expression changes and spatial heterogeneity in response to acute and chronic fluoxetine treatment.

EEG connectivity changes in early response to antidepressant treatment

The paper identifies changes in EEG connectivity metrics as potential indicators of early antidepressant treatment response in major depressive disorder patients.

Cohort Profile: Investigating Antidepressant Response within Generation Scotland

The paper describes the AMBER program's cohort profile, collecting questionnaire data on antidepressant response from Generation Scotland participants to develop phenotypes and link with biological data.

The atypical antidepressant tianeptine causes opioid-receptor-dependent beta oscillations in the rat hippocampus

The paper investigates how the antidepressant tianeptine affects beta oscillations in the rat hippocampus through opioid receptor mechanisms.

mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

The paper identifies proteomic changes in mPFC synaptosomes of mice exposed to inescapable stress, highlighting muscarinic receptor alterations and signaling pathway disruptions linked to depression.

Transcriptional Profiles of Antidepressant Resistance Across the Corticolimbic Pathway of Chronically Stressed Mice

This study identifies transcriptional differences in mice with antidepressant resistance using RNA sequencing of brain regions after stress and drug treatment.

A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants

This paper identifies a brain-enriched circRNA in blood that predicts response to SSRI antidepressants and is regulated by 5-HT2A and BDNF signaling.

Astrocyte ezrin defines resilience to stress-induced depressive behaviours in mice

This study shows that increasing ezrin in astrocytes makes mice more resilient to stress-induced depressive behaviors, while decreasing it increases susceptibility.

A tale of two receptors: simultaneous targeting of NMDARs and 5-HT4Rs exerts additive effects against stress

This study investigates the combined effects of (R,S)-ketamine and prucalopride on stress-induced behaviors and neural activity, finding additive benefits in reducing fear, despair, and hyponeophagia.

Ketamine reverses chronic stress-induced behavioral changes via Ca2+-permeable AMPA receptors in mice

This study shows low-dose ketamine reverses chronic stress-induced behavioral issues in mice by activating Ca2+-permeable AMPA receptors in the hippocampus.

Key contribution of prefrontal inhibition to passive coping behaviour: chronic stress and fast-acting antidepressant

This study shows that the rostral prelimbic cortex's excitation/inhibition balance modulates passive coping behavior, which is affected by chronic stress and reversed by the fast-acting antidepressant HNK.

Gene expression signatures of response to fluoxetine treatment: systematic review and meta-analyses

This paper conducts a systematic review and meta-analysis of gene expression data from fluoxetine treatment in humans and rodents to identify pathways associated with treatment response and resistance.

Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem study

The paper identifies molecular signatures in the anterior insula and subgenual ACC brain network associated with mood disorders and suicide outcomes using postmortem RNA-sequencing data.

Machine Learning-Based Model for Behavioral Analysis in Rodents: Application to the Forced Swim Test

The paper introduces a machine learning model using 3D RCNN to automate behavioral analysis in the Forced Swim Test, accurately distinguishing swimming, climbing, and immobility behaviors in rodents.

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Transcription driven repurposing of cardiotonic steroids for Lithium treatment of severe depression

The paper identifies cardiotonic steroids as potential repurposing candidates for lithium treatment of severe depression based on transcriptional and epidemiological analyses.

Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens

This study shows ketamine rescues stress-induced anhedonia in mice by cell-type-specific adaptations and input-specific synaptic changes in the nucleus accumbens.

RAPID HIPPOCAMPAL SYNAPTIC POTENTIATION INDUCED BY KETAMINE METABOLITE (2R,6R)-HYDROXYNORKETAMINE PERSISTENTLY PRIMES SYNAPTIC PLASTICITY

This study shows that HNK rapidly potentiates hippocampal synapses and primes long-term plasticity through PKA-dependent mechanisms, suggesting new antidepressant strategies.

Brain Structural Correlates of an Impending Initial Major Depressive Episode

The paper identifies neural markers of impending initial major depressive episodes by comparing converters, MDD patients, and healthy controls using voxel-wise gray matter volume analysis.

Safety concerns following the use of ketamine as a potential antidepressant for adolescent rats of both sexes

This study evaluates the antidepressant-like effects and safety of ketamine in adolescent rats, finding sex-dependent efficacy and safety concerns.

The disappointment centre of the brain gets exciting: A systematic review of habenula dysfunction in depression

This paper reviews preclinical and clinical studies on habenula dysfunction in depression, finding hyperactivity in preclinical models and structural/molecular abnormalities in clinical studies, with limited sex-specific analysis.

Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses

This study investigates how ketamine affects GABAergic and glutamatergic activity in the mPFC, showing a biphasic effect on GABA neurons and their role in sustained antidepressant responses.

Proteomic evidence of depression-associated astrocytic dysfunction in the human male olfactory bulb

This study identifies proteomic changes in the human male olfactory bulb associated with depression, highlighting astrocytic dysfunction and species-specific differences in mouse models.

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

Ketamine induces multiple individually distinct whole-brain functional connectivity signatures

This study investigates how ketamine induces distinct whole-brain functional connectivity patterns in individuals and links these patterns to gene expression and behavioral responses.