Nuclear Structure and Function

ERM proteins support perinuclear actin rim formation

The paper shows ERM proteins link actin filaments to the nuclear envelope by forming a perinuclear actin rim in melanoma cells.

Nucleus softens during herpesvirus infection

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity

This study shows that nuclear and actin mechanics change from G1 to G2, leading to decreased nuclear stiffness and increased vulnerability to rupture.

Analysis of Treacher Collins syndrome 4-associated mutations in Schizosaccharomyces pombe

This study investigates TCS4-associated mutations in S. pombe by analyzing their effects on rRNA transcription and cell growth.

Nuclear Pore Complexes in Various States of HL-60/S4 Cells

This study examines how nuclear pore complex structure and function change under different cellular stresses in HL-60/S4 cells using GSEA.

Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activation.

This study shows lamin A/C maintains genome structure and transcriptional programs needed for EBV-driven B cell activation, with loss causing chromatin reorganization and gene expression changes.

Alphafold 3 guided insights into the Importin b / Importin 7 heterodimer interaction and its binding to Histone H1

The paper uses Alphafold3 to predict and validate the structure of the Imp{beta}/Imp7/H1 complex, showing H1 binds to Imp7 rather than Imp{beta} and identifying key interaction regions.

The Nucleoporin MLP1 of the nuclear basket is essential for nuclear integrity and ploidy maintenance in Trypanosoma brucei

This study shows that MLP1, a nuclear pore complex protein in Trypanosoma brucei, is essential for nuclear integrity, mRNA export, and genome stability by maintaining proper chromosome segregation and ploidy.

Topoisomerase I inhibition suppresses nuclear blebbing via RNA Pol II stalling and nuclear stiffening

The paper shows camptothecin suppresses nuclear blebbing by stalling RNA Pol II and increasing chromatin stiffness.

RCC1 depletion drives protein transport defects and rupture in micronuclei

This study identifies RCC1 depletion as a cause of protein transport defects and micronuclei rupture, linking it to nuclear lamina defects and genome instability.

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin

This study identifies primary target pathways of progerin in HGPS patients through transcriptomic analysis, revealing mTORC1, UPR, UV response, apoptosis, and TNF signaling as key affected pathways.

Nucleolar reorganization on stress depends on physicochemical changes due to nascent rRNA synthesis

This study shows that nucleolar reorganization under stress is driven by changes in nascent rRNA synthesis, not signaling pathways.

A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding

This paper challenges the established model of actin import by showing IPO9 directly binds monomeric actin and competes with cofilin and profilin for actin binding.

ZNF16 is a nucleolar-associated protein that regulates expression of the rDNA and cancer-associated genes

This study identifies ZNF16 as a nucleolar protein that regulates rDNA transcription and cancer-related genes, showing its role in cell viability and multiple biological pathways.

Differential Crosslinking and Contractile Motors Drive Nuclear Chromatin Compaction

The paper models nuclear chromatin compartmentalization using crosslinking, contractile motors, and deformable lamina, showing how these factors drive genomic segregation and heterochromatin formation.

Kap-centric Nsp1-mediated nuclear transport at full amino-acid resolution

This study presents a modeling framework simulating nuclear transport at full amino-acid resolution, revealing the dynamic FG-meshwork and role of Nsp1 and NTRs in transport.

O-GlcNAcylation and an importin-β radial gradient keep the FG barrier liquid in live-cell nuclear pores

The paper shows FG-NUPs in live cells exhibit liquid-like mobility, while in vitro they transition to solid, with O-GlcNAcylation and importin-β maintaining the dynamic FG network's liquidity.

Paclitaxel compromises nuclear integrity in interphasethrough SUN2-mediated cytoskeletal coupling

This study shows paclitaxel causes nuclear damage in interphase via SUN2-mediated Lamin A/C disruption, revealing an additional mechanism beyond its known mitotic effects.

Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients.

The paper shows reduced ZMPSTE24 leads to prelamin accumulation and steatosis in MASLD patients, linking it to p53 activation and metabolic dysfunction.

Nuclear envelope dysfunction drives premature aging and modulates heterochromatic methylome drift in Arabidopsis

This study shows that nuclear envelope integrity maintains epigenetic stability in Arabidopsis by coupling chromatin organization to epigenomic drift during aging.

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

Dissociation of the nuclear basket triggers chromosome loss in aging yeast

This study shows that nuclear basket displacement in aging yeast causes chromosome loss by disrupting pre-mRNA quality control and asymmetric segregation.

Importin α/β1 dependent nuclear import of Black Sea Bass Polyomavirus Large Tumor Antigen is mediated by a classical NLS located downstream of the SF3 helicase domain

The paper identifies a classical NLS in Black Sea Bass Polyomavirus LTA that mediates nuclear import via Importin α/β1, distinct from mammalian PyVs.

Golgi-associated nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection

This study shows that importin-7 facilitates HPV transport from the Golgi to the nucleus, promoting infection by binding to the HPV capsid protein L2.

An evolutionarily conserved role for separase in the regulation of nuclear lamins

This study shows that separase interacts with nuclear lamins in Drosophila and humans, affecting nuclear organization and lamin levels, indicating an evolutionarily conserved role.

Defining the impact of rRNA processing on nucleolar organization and function

This study shows that impaired 5'ETS pre-rRNA cleavage disrupts nucleolar organization, leading to mislocalization of RNA and proteins, and broader nuclear architecture changes.

Lamin B loss in nuclear blebs is rupture dependent while increased DNA damage is rupture independent

The paper measures lamin B and DNA damage in blebbed nuclei to determine the effect of nuclear rupture, finding lamin B loss is rupture-dependent while DNA damage is independent.

Translocation of HIV capsid core through the Nuclear Pore Complex by affinity gradient

This paper investigates how HIV capsid core translocates through the Nuclear Pore Complex by analyzing FG repeat interactions and identifies an affinity gradient that facilitates unidirectional translocation.

SWING regions prime chromatin for nuclear speckle mediated gene regulation

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

Nuclear lamina-associated domain biogenesis is regulated by nuclear pore density during embryogenesis and mediates UV protection

The paper shows that nuclear pore density regulates LAD formation during C. elegans embryogenesis, with heterochromatic LADs providing UV protection.