Nuclear Structure and Function

Nup43 positively regulates Drosophila fertility and Myosin VI-dependent actin cone assembly during spermiogenesis

This study shows Nup43 is essential for Drosophila fertility and actin cone assembly during spermiogenesis, with Myosin VI partially rescuing actin cone defects but not sterility.

The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

This study shows that AMPK regulates NPP-16/NUP50 to enhance lipid catabolism and extend C. elegans lifespan, independent of its nuclear transport function.

Coordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor

The paper identifies TOP2B as a regulator of genome-nuclear lamina interactions, showing its role in partitioning genomic regions between the nuclear lamina and interior, with LBR playing a complementary role.

Muscular dystrophy-associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis controlling cytoplasmic macromolecular crowding

This study identifies a nucleolar-ribosomal axis linking lamin mutations to cytoplasmic biophysical changes in EDMD, revealing a new pathway for laminopathy pathogenesis.

The Arabidopsis nucleoporins 98A/B are essential for NLP7 nuclear accumulation in response to nitrate

This paper shows that Arabidopsis NUP98A/B nucleoporins are required for nitrate-induced nuclear accumulation of NLP7, a transcription factor critical for nitrate response and plant growth.

Methionine matters: a common mechanism of viral inhibition of host defense identified via AI-assisted molecular dynamics

The paper identifies a common mechanism across diverse viruses that use methionine residues to inhibit host defense by blocking the Rae1-Nup98 complex, supported by AI-assisted molecular dynamics.

Nuclear Pore Transport: Toward an Integrated Perspective

The paper compares single-molecule trajectories with correlation-based measurements to show that nuclear pore transport occurs rapidly through FG-nucleoporin dynamics.

Prelamin A Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss

This study shows that prelamin A does not cause vascular smooth muscle loss or atherosclerosis, unlike progerin in HGPS.

Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing

The paper shows that wound healing in Drosophila involves reversible chromatin-lamina dewetting triggered by mechanical changes, leading to cellular contraction and tissue repair.

Genome - nuclear lamina interactions are multivalent and cooperative

The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.

Disruption of nucleolar integrity triggers cellular quiescence through organelle rewiring and secretion

This study identifies a stress response pathway linking nucleolar disruption to cellular quiescence and secretion, revealing its role in cancer progression.

Identification of divergent Toxoplasma Nuclear Pore Complex components highlights speciation of mRNA export machinery

This study identifies and characterizes novel nuclear pore complex components in Toxoplasma gondii, revealing divergence in mRNA export machinery compared to other eukaryotes.

Detection and electron microscopic study of thick cross-striated linear fibrils in mammalian cell nuclei

The paper detects thick cross-striated fibrils in mammalian cell nuclei using electron microscopy and shows their structural associations with chromatin and nuclear matrix.

Nuclear morphology and chromatin organization modulate T cell cytoskeletal remodeling and immune synapse formation

This study shows that chromatin compaction influences T cell spreading and immune synapse formation by modulating actin cytoskeletal organization.

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

Nucleolar and Chromatin Remodeling during γ-Irradiation-Induced Mitotic Catastrophe: Live-Cell Imaging Correlated with UBTF and Fibrillarin 3D Redistribution

This study uses live-cell imaging to track nuclear and nucleolar changes during γ-irradiation-induced mitotic catastrophe and apoptosis in HeLa cells, revealing distinct stages of nuclear deformation and nucleolar remodeling.

The small GTPase Ran defines Nuclear Pore Complex asymmetry

This study shows that the small GTPase Ran controls the asymmetry of nuclear pore complexes by regulating their peripheral configuration in budding yeast and Drosophila.

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

The paper identifies sequences affecting emerin's secretory trafficking, showing C-terminal tags and hydrophobic domains influence its lysosomal fate, while an ER retention motif stabilizes it.

Competitive binding and geometric changes allow fast, complete translocation of intact HIV-1 capsids through the nuclear pore complex

This paper develops a biophysical model to explain how HIV-1 capsids translocate through the nuclear pore complex, showing that competitive binding and geometric changes enable fast and complete nuclear import.

Nuclear mechanostability emerges from satellite DNA condensation into chromocenters

This study shows that nuclear mechanostability arises from satellite DNA condensation into chromocenters, which help dissipate mechanical stress and protect genome integrity.

rRNA intermediates dictate nucleolar architecture in C. elegans

This study shows that rRNA intermediates influence nucleolar structure in C. elegans by altering protein distribution and causing architectural changes.

Nuclear basket proteins Nup2 and Mlp1 drive heat shock-induced 3D genome restructuring downstream of transcriptional activation

This study shows that Nup2 and Mlp1 drive 3D genome restructuring of HSR genes after transcriptional activation during heat shock in budding yeast.

In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

The HIV-1 Nuclear Export Complex Reveals the Role of RNA in Crm1 Cargo Recognition

The paper determines the cryo-EM structure of the HIV-1 nuclear export complex, revealing how RNA interacts with Crm1 through specific binding sites and contacts.

The molecular basis of lamin-specific chromatin interactions

This study identifies the molecular interactions between lamin isoforms and chromatin, revealing their role in chromatin organization and epigenetic regulation.

Peripheral heterochromatin tethering is required for chromatin-based nuclear mechanical response

The paper investigates how peripheral heterochromatin tethering influences nuclear mechanical response through simulations and experiments.

Detecting Nuclear Pore Complex assembly in living cells

This paper introduces a nanobody-based method to detect newly forming nuclear pore complexes in yeast, revealing novel insights into their assembly and localization.

Sp100-HMG drives 'inside-out' PML-NB assembly to modulate transcription and cell-cycle dynamics

This study identifies Sp100-HMG as a master liquid nucleator that drives 'inside-out' PML-NB assembly, modulating transcription and cell-cycle dynamics through hierarchical condensation.

The inner nuclear membrane-associated protein Csa1 regulates lipid droplet biogenesis and nuclear shape in a Sir2-dependent manner

This study identifies a Sir2-dependent Csa1-Lro1 pathway at the inner nuclear membrane that regulates lipid droplet formation and nuclear shape in budding yeast.

The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome

The age-related accumulation of progerin in smooth muscle cells (SMCs) explains the loss of arterial SMCs in Hutchinson-Gilford progeria syndrome.