Multiple Sclerosis Research Studies

Dissecting the evolving cellular landscape of a remyelinating microenvironment

The paper analyzes gene expression dynamics in a remyelinating microenvironment using single nucleus RNA sequencing in mice, revealing shifts in microglial, astrocytic, and fibroblast activities linked to oligodendrocyte differentiation.

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry

This study identifies a gut microbiome-derived peptide that mimics a myelin antigen and induces experimental autoimmune encephalomyelitis in mice.

RiboTag-based RNA-Seq uncovers oligodendroglial lineage-specific inflammation in autoimmune encephalomyelitis

This study identifies inflammatory gene expression changes in oligodendroglial lineage cells during EAE using RiboTag-based RNA-Seq, revealing their role in neuroinflammation.

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glia responses

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis

This study identifies proteomic differences in neutrophils from MS patients compared to healthy donors, highlighting dysregulated granule proteins and MAVS signaling, and impaired T cell suppression.

GWAS highlights the neuronal contribution to multiple sclerosis susceptibility

This study identifies 236 MS susceptibility variants and highlights neuronal and glial dysfunction as key factors in MS susceptibility.

Impaired activation of the prefrontal executive network during working memory processing in multiple sclerosis

This paper uses TDE-HMM to analyze MEG data from a working memory task in MS patients, identifying altered activation patterns in specific brain networks linked to cognitive impairment and treatment effects.

Gene expression and alternative splicing analysis in a large-scale Multiple Sclerosis study

The paper analyzes gene expression and alternative splicing in MS using RNA-seq data to identify differentially expressed genes, spliced transcripts, and SNVs associated with disease pathways and potential therapeutic targets.

Antigen-Specific modulation of MS/EAE by TCR-like Antibody Targeting Auto-Reactive Epitope

This study demonstrates that TCR-like antibodies targeting the MOG35-55 epitope can prevent and regress EAE by blocking TCR-MHC interactions and modulating APCs.

Senolytic treatment depletes microglia and decreases severity of experimental autoimmune encephalomyelitis.

This study shows that senolytic treatment reduces microglia and alleviates EAE symptoms in mice, suggesting senescent glia contribute to neuroinflammation.

Spatial Transcriptomics of Meningeal Inflammation Reveals Inflammatory Gene Signatures in Adjacent Brain Parenchyma

The paper uses spatial transcriptomics to study meningeal inflammation in a mouse model, identifying inflammatory gene signatures in adjacent brain parenchyma and highlighting candidate pathways in grey matter pathology.

A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis

This paper develops a novel mouse model of cerebral adrenoleukodystrophy (cALD) that replicates human disease features and highlights NLRP3 inflammasome activation in lesion pathogenesis.

Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

Microglial states determine lesion dynamics in multiple sclerosis

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

Aberrant iron deposition in the multiple sclerosis spinal cord relates to neurodegeneration

This study shows that iron accumulates abnormally in the spinal cord of MS patients, correlating with oxidative stress and neurodegeneration, but not with demyelination or iron-rimmed lesions.

Remyelination protects neurons from DLK-mediated neurodegeneration

This study shows that remyelination protects neurons from DLK-mediated neurodegeneration by preventing apoptosis and inflammation in a mouse model of demyelination.

Linking myelin and Epstein-Barr virus specific immune responses in multiple sclerosis: insights from integrated public T cell receptor repertoires

This study analyzes T cell receptor repertoires in MS patients and controls to explore the relationship between EBV-specific and myelin-specific immune responses, finding distinct patterns associated with MS.

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

Probing the basis of disease heterogeneity in multiple sclerosis using genetically diverse mice

This study uses genetically diverse mice to identify genetic loci associated with different disease progression patterns in multiple sclerosis.

BRD4 expression in microglia supports recruitment of T cells into the CNS and exacerbates EAE

This study shows that microglia-specific Brd4 knockout reduces T cell reactivation and EAE pathology by impairing microglia-T cell interactions and neuroinflammation.

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

The paper uses iPSC-derived glia cultures from MS patients to identify glia-intrinsic disease mechanisms and potential therapeutic targets.

TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

Uncovering immune characteristics of neurons in the context of multiple sclerosis and experimental autoimmune encephalomyelitis

This study identifies immune gene expression signatures in neurons from MS patients and EAE mice, revealing shared pathways and potential roles for IRF5 and STAT1 in neuronal inflammation.

Low intensity repetitive transcranial magnetic stimulation enhances remyelination by newborn and surviving oligodendrocytes in the cuprizone model of toxic demyelination

This study shows that low intensity repetitive transcranial magnetic stimulation (LI-rTMS) enhances remyelination by increasing myelin production from new and surviving oligodendrocytes in a mouse model of demyelination.

Glia-enriched stem-cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis

This study develops a glia-enriched 3D brain model from human iPSCs that mimics MS-related neurodegenerative phenotypes and intercellular communication.

Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus

This study identifies EOMES+Tr1-like regulatory T-cells in MS that produce IL-10 and are activated by EBV, suggesting their impaired function contributes to immune escape.

Differentiation of Acute Disseminated Encephalomyelitis from Multiple Sclerosis Using a Novel Brain Lesion Segmentation and Classification Pipeline

This paper introduces a novel pipeline to differentiate ADEM from MS using MRI imagery, achieving 90% accuracy on a new ADEM dataset.

Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis

The paper identifies reduced CBX5 expression and impaired Integrator activity in MS patients, linking them to transcriptomic alterations and disease progression.

Polygenic susceptibility for multiple sclerosis is associated with working memory in low-performing young adults

This study links polygenic MS risk to working memory performance in low-performing young adults but not to white matter properties.

Unbiased multiplex antigen screening of Cerebrospinal Fluid detects microbial and autoantigenic epitopes associated with Multiple Sclerosis

The paper screens cerebrospinal fluid from MS and non-MS patients using a multiplex peptide library to identify microbial and autoantigenic epitopes enriched in MS.