Cancer Cells and Metastasis

Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model

This study evaluates the anti-breast cancer activity of monensin and its analogs in organoid models, finding they reduce stem-like cell proliferation and dysregulate stemness markers.

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation

This study shows DDR1 regulates RUNX1-CBFβ to drive breast stem cell differentiation into multiple lineages and tissue structures.

Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids

This study shows that mesenchymal-epithelial transition (MET) in breast cancer cells reduces proliferation but enhances immune evasion, suggesting MET promotes tumor outgrowth through immune survival rather than proliferation.

Circulating tumor cell heterogeneity and MMP9 expression in clinical correlation with breast cancer

This study examines the link between circulating tumor cell subtypes, MMP9 expression, and clinicopathological features in breast cancer patients, finding significant associations with lymph node metastasis and EMT.

Developing in vitro patient derived CERvical Cancer OrganoidS (CERCOS) as a potential preclinical tool in cervical cancer research

This study establishes patient-derived cervical cancer organoids (CERCOS) that preserve genetic and phenotypic features of the parent tissue, serving as a platform for precision medicine and biobanking.

Modeling the role of urokinase plasminogen activator, uPA, and circulating Cancer-Associated Fibroblasts (cCAFS) in breast cancer cell extravasation

This study shows that circulating cancer-associated fibroblasts (cCAFs) enhance breast cancer cell extravasation by promoting urokinase plasminogen activator (uPA) expression, facilitating metastasis.

Differentiation status determines tumorigenicity and immunogenicity of cancer cells

This study shows that cancer cell tumorigenicity and immunogenicity are inversely related to their differentiation status, with differentiation suppressing tumorigenicity and enhancing immunogenicity.

Klf4-dependent pivotal role of smooth muscle-derived Gli1+ lineage progenitor cells in lung cancer progression

This study identifies AdvSca1-SM cells as a key component of lung tumors and shows that Klf4-dependent regulation of these cells affects cancer progression and immunotherapy response.

Plastimos: a live cell imaging-based framework to study dynamics of EMT-mediated cellular plasticity in breast cancer

Plastimos quantifies EMT-mediated cellular plasticity in breast cancer cells using live cell imaging and deep learning, showing differential responses to EGF and TGF-β1.

EMT Induction In Normal Breast Epithelial Cells By COX2-Expressing Fibroblasts

This study shows COX2-expressing fibroblasts induce EMT in normal breast epithelial cells through paracrine signaling, suggesting a mechanism for tumor progression.

Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

This study identifies MCSP+ melanoma cells as early metastasis founder cells in lymph nodes and shows they activate immunosuppression to evade CD8 T cell attack.

Ancestry-linked stromal variations impact breast epithelial cell invasion

The paper investigates how ancestry-linked stromal variations, specifically PZP cells, influence breast epithelial cell invasion in African and European ancestry individuals.

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

KLF7-Regulated ITGA2 as a Therapeutic Target for Inhibiting Oral Cancer Stem Cells

This study identifies ITGA2 as a therapeutic target regulated by KLF7 that sustains oral cancer stemness and drug resistance through interactions with collagen and activation of stemness pathways.

Red blood cell-tumour cell interactions promote tumour cell progression

This study shows that red blood cells from cancer patients enhance tumour cell invasiveness and metastatic potential through gene and protein changes, suggesting PAK4 as a therapeutic target.

Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism

This study identifies the netrin-1/UNC5B/TFF3 axis as a regulator of colorectal cancer stem cell self-renewal and shows that targeting it with NP137 enhances chemotherapy efficacy in preclinical models.

Heterogeneous therapy-resistant cancer cells have distinct and exploitable drug sensitivity profiles

The paper shows that therapy-resistant cancer cell clones have distinct drug sensitivity profiles, and combinations targeting these subpopulations can effectively eliminate resistant populations.

Progesterone Receptor Expressing Basal Cells and Progesterone Receptor-Primed Progenitors Redefine the Mammary Epithelial Hierarchy

The paper identifies PR-expressing basal cells and PR-primed progenitors, redefining mammary epithelial hierarchy and challenging existing models of breast biology and cancer.

Single cell resolution of an epigenetic signature of persister tumor cell

The paper identifies an epigenetic signature associated with persister tumor cells in ovarian cancer that correlates with chemotherapy resistance and defines the persister state.

CLM296: a highly selective inhibitor targeting ALDH1A3-driven tumor growth and metastasis in breast cancer

This paper introduces CLM296, a highly selective ALDH1A3 inhibitor that reduces tumor growth and metastasis in TNBC xenografts with favorable pharmacokinetics and safety profile.

Immune Niche Formation in Engineered Mouse Models Reveals Mechanisms of Tumor Dormancy

This study identifies immune-tumor interactions that drive tumor dormancy in a mouse model, highlighting IFN-γ-KLF4-SLURP1 and CD200-CD200R1 pathways.

MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer

This study shows MYBL2 maintains stemness and promotes theta-mediated end joining in TNBC, and identifies Pol{theta}/ATR inhibition as a therapeutic strategy.

TWIST1 mediated transcriptional activation of SPON2 drives colorectal peritoneal metastasis through activation of cancer-associated fibroblast signaling network

This study identifies the SPP1-TWIST1-SPON2 signaling axis as a driver of colorectal peritoneal metastasis through cancer-associated fibroblast signaling.

Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity

The paper models EMT dynamics across cancers to identify genes associated with intermediate states and plasticity, finding SFN and NRG1 as key markers.

Tumoral CD24 tunes platelets binding and pro-metastatic functions

This study identifies CD24 as a regulator of tumor cell-platelet interactions that enhance metastatic potential and suggests it as a druggable target.

Exploring the mechanisms of early acquired resistance to doxorubicin in melanoma spheroids

This study examines how melanoma spheroids develop early resistance to doxorubicin through adaptive molecular changes, including upregulated angiogenesis and cell migration.

Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis

This study identifies DNM1 as a master regulator of EMT in ovarian cancer, showing it sustains the mesenchymal state through N-cadherin endocytic recycling and promotes metastasis.

Integrin-TGFb axis induces partial EMT in basal-like cells to lead collective invasion

The paper identifies the Itg2-TGFβ axis as a regulator of partial EMT in basal-like breast cancer cells, promoting collective invasion while maintaining cell cohesion.

Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis

The paper identifies a rare subset of CD4 and CD8 double positive T cells that form clusters with circulating tumor cells, promoting cancer metastasis through immune suppression and integrin-mediated interactions.

Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone

This study identifies TIMELESS as a critical regulator of metastasis-initiating cell survival and reawakening in bone, with a metabolic inhibitor showing promise for therapeutic intervention.