Cancer Cells and Metastasis

Inferring EMT dynamics from cell cycle profiles using a hidden Markov framework

The paper infers EMT dynamics from cell cycle profiles using a hidden Markov model, showing it can reconstruct EMT trajectories from cell cycle data alone.

Spatial self-organization of cancer stem cell niches revealed by live single-cell imaging

The paper uses live single-cell imaging to show cancer stem cells form spatial niches and undergo reprogramming influenced by both lineage and cell-cell interactions.

Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System

The paper develops a mouse model of metastatic dormancy and identifies unique phenotypic and molecular features of dormant metastases controlled by the immune system.

Neoplastic immune mimicry potentiates breast tumor progression

This study identifies immune mimicry in breast cancer cells, where neoplastic cells express leukocyte receptors, enhancing tumor aggressiveness and therapy resistance.

Self-organization of tumor heterogeneity and plasticity

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

A Patient-Derived Scaffold-Based 3D Culture Platform for Head and Neck Cancer: Preserving Tumor Heterogeneity for Personalized Drug Testing

Myofibroblastic CAFs arising from bone-resident osteoblast precursors retain an osteolineage signature and support breast cancer progression via Osterix-mediated signaling.

Non-centromeric CENP-A epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells

This study shows that CENP-A, a centromeric histone variant, epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells through non-centromeric mechanisms.

Serial Imaging of Tumour and microEnvironment (SITE) platform for live-cell ex vivo modelling of primary and metastatic cancer dynamics

The paper introduces the SITE platform for live-cell ex vivo modeling of cancer and TME interactions, revealing tissue-specific dynamics and ERK signaling patterns in breast cancer.

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

This study shows that capillary constrictions reprogram melanoma cells to a tumorigenic cancer stem cell-like state via PIEZO1 mechanosensing.

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

Primary cilia promote EMT-induced triple-negative breast tumor heterogeneity and resistance to therapy

This study shows primary cilia in TNBC cells contribute to chemoresistance by supporting EMT-driven heterogeneity and stemness, and inhibiting ciliogenesis reduces this resistance.

Loss of Sox10 prevents tumor initiation and induces luminal-to-basal reprograming in a HER2+ mouse model.

This study shows that Sox10 deletion in luminal cells of HER2+ mice prevents tumor initiation and reprograms tumor cells to a basal phenotype.

L1CAM signaling through planar cell polarity generates SOX2+ metastatic progenitors in lung adenocarcinoma

The paper identifies L1CAM-driven planar cell polarity signaling as a mechanism promoting SOX2+ metastatic progenitors in lung adenocarcinoma.

Resistance Signatures Manifested in Early Drug Response in Cancer and Across Species

This study identifies early transcriptional signatures of drug resistance in cancer and across species, showing conservation and predictive value for treatment response.

Multiple distinct metastatic cell states are induced by epithelial-mesenchymal plasticity

This study identifies multiple metastatic cell states in TNBC through EMT plasticity, showing that metastatic competence arises from diverse EMT programs rather than a single phenotype.

Fine needle aspiration biopsy of breast specimens effectively harvests cells for patient-derived organoids modeling breast ductal carcinoma in situ

This study shows that fine needle aspiration biopsy (FNAB) effectively harvests cells for patient-derived organoids modeling breast ductal carcinoma in situ, with faster growth times compared to core needle biopsy.

Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome

This study uses deep learning and spatial data to show how tumor architecture and cell states co-evolve, influencing colorectal cancer outcomes.

Testing the plasticity-first theory of tumor evolution with spatiotemporal lineage tracing

This study uses lineage tracing and single-cell analysis to show tumor plasticity precedes stable immune evasion, with AP-1 regulating EMT stabilization during immunotherapy.

GSTT1 mediates stemness and FGFR inhibitor sensitivity in pancreatic cancer through regulation of CD133 (PROM1)

This study identifies GSTT1HighCD133High cells as a stem-like subpopulation in pancreatic cancer that is sensitive to FGFR inhibitors, highlighting a therapeutic target.

Next-Generation Breast Organoids Capture Tissue Organogenesis with High-Resolution Live Imaging

This paper introduces a breast organoid model that captures tissue organogenesis with high-resolution live imaging, revealing novel morphogenesis processes and stromal generation.

Transient CB2 receptor activation triggers irreversible luminal differentiation via chromatin remodeling in breast cancer

The paper shows that transient CB2R activation in breast cancer cells leads to irreversible luminal differentiation through chromatin remodeling, enhancing tamoxifen response and reducing resistance.

Metastasis-associated wound repair promotes reciprocal activation of the lung epithelium and breast cancer metastases during outgrowth

This study shows that lung epithelial cells promote breast cancer metastasis through wound repair mechanisms, and targeting CREB signaling with PDE4 inhibitors can reduce metastatic outgrowth.

LeGO-Teknik reveals that the neurogenesis pathway is a clone-specific hallmark of brain metastasis in breast cancer

The paper identifies neurogenesis-related gene expression as a clone-specific hallmark of brain metastasis in breast cancer using a new optical barcoding tool.

Targeted disruption of Oncogenic Biosphere: A Paradigm Shift Beyond Cancer Cell-Centric Therapies

This paper demonstrates that targeting the tumor microenvironment, specifically cancer-associated fibroblasts, with a novel nanotherapeutic called Penetrium can overcome resistance and metastasis in cancer models.

S-Nitrosylated COX-2 is a TME-regulated breast cancer biomarker of mesenchymal phenotypes

This study identifies SNO-COX-2 as a biomarker for mesenchymal phenotypes in breast cancer, showing its microenvironmental regulation and association with invasive growth.

Induction of pluripotent oncogenic stem cells from mouse fibroblasts

The paper shows that cell-free chromatin particles from cancer patients can transform mouse fibroblasts into cancer stem cells capable of forming tumors and expressing germline markers.

Optimized large-scale longitudinal biorepository of gastroesophageal adenocarcinoma patient-derived organoids: High-fidelity models for personalized treatment to overcome resistance.

The paper establishes a large-scale biobank of GEA patient-derived organoids that accurately model tumor features and drug responses, enabling personalized treatment strategies.

Regnase-1 Promotes Tumor-Initiating Activity in Non-Small Cell Lung Cancer

This study shows Regnase-1 promotes tumor-initiating activity in NSCLC by suppressing the SOX2 pathway, and its inhibition reduces tumor growth and enhances anti-cancer immunity.