Angiogenesis and VEGF in Cancer

MT4-MMP-mediated NRP1 shedding fine-tunes VEGFA signaling dynamics during embryonic brain angiogenesis

This study identifies MT4-MMP as a regulator of NRP1 shedding, which modulates VEGFA signaling during embryonic brain angiogenesis and wound repair.

Integrin-independent Tie2 activation using de novo designed proteins

This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.

Tie2 signaling in the tumor microenvironment orchestrates breast cancer cell dissemination through TMEM doorways

This study identifies macrophage Tie2 signaling as critical for TMEM doorway-mediated vascular permeability and metastatic dissemination in breast cancer.

Antibodies blocking PlGF or VEGF interactions with the NRP1 receptormediate anti-proliferative effects

The paper identifies antibodies that block PlGF or VEGFA interactions with NRP1, showing anti-proliferative effects in cancer cells and reduced angiogenesis.

Reelin engages non-canonical signaling pathways to drive endothelial remodeling and plasticity

This study identifies Reelin as a regulator of endothelial plasticity through non-canonical FAK- and AKT-dependent pathways, promoting vascular remodeling without full mesenchymal transition.

CD31+ T-cells express greater VEGF-A and CXCR4 levels than CD31- counterparts with VEGF-A expression exacerbated with advancing age

The paper compares VEGF-A and CXCR4 levels in CD31+ and CD31- T-cells across age groups, finding higher VEGF-A in CD31+ T-cells and increased levels with age.

Ubiquitin ligase CHFR impairs Tie2 signaling via K48-linked ubiquitylation and degradation of Akt1 in endothelial cells

This study identifies CHFR as a regulator of endothelial inflammatory responses by promoting Akt1 ubiquitylation and degradation, thereby impairing Tie2 signaling and endothelial barrier integrity.

Mechanistic Insights into 2-5(H)-Furanone-Mediated Inhibition of Angiogenesis Using HUVECs and Zebrafish Models

This study evaluates the anti-angiogenic effects of 2-5(H)-Furanone using HUVECs and zebrafish models, showing dose-dependent inhibition of angiogenesis through molecular and functional mechanisms.

Regulation of PDGF-BB Signaling in Placental Pericytes by Soluble PDGFRβ Isoforms: Implications for Fetoplacental Vascular Development

This study identifies progressive pericyte recruitment to placental capillaries and shows that soluble PDGFRβ isoforms modulate PDGF-BB signaling in response to hypoxia.

Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury

This study identifies VEGF-D as a key factor in maintaining lung vascular integrity during acute lung injury using single-cell RNA sequencing and functional assays.

A novel mouse model of hypertensive emergency with multiorgan microvascular disease implicating the VEGFA/sFlt-1 balance

This study develops a mouse model of hypertensive emergency with multiorgan microvascular disease and identifies dysregulated VEGFA/sFlt-1 signaling as a key driver.

Transcriptomic Profiles from Normal and Tumor Tissue Samples Reveal Distinct Venule Populations and Novel Tumor Endothelial Cell Markers in Breast Cancer

This study identifies distinct venule populations and novel tumor endothelial cell markers in breast cancer using single-cell RNA-seq data from normal and tumor tissues.

Kindlin-2-Moesin interaction orchestrates sprouting angiogenesis via modulating endothelial membrane mechanics and VEGF signaling

This study identifies Kindlin-2-Moesin interaction as a regulator of sprouting angiogenesis by modulating endothelial membrane tension and VEGF signaling.

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer

This study identifies Notch3 as a regulator of pericyte phenotypic plasticity in colorectal cancer, showing its role in promoting proliferation and altering contractile properties.

The REFLEX system enables in vivo identification of perivascular angiogenic macrophages in the heart

The paper develops REFLEX and HUNTERuni-seq to identify perivascular angiogenic macrophages (PVAMs) that deliver VEGF-A to endothelial cells, showing physical contact is critical for effective signaling.

Complex relationship among vessel diameter, shear stress and blood pressure controlling vessel pruning during angiogenesis

The paper develops a predictive model for vessel pruning during angiogenesis using machine learning, finding that shear stress, blood pressure, and vessel radius are tightly correlated with pruning sites.

Pathological angiogenesis RNA network analysis reveals a VEGF-independent gene signature with prognostic power for HER2+ breast cancer

The paper identifies a VEGF-independent gene signature for HER2+ breast cancer using RNA network analysis and validates its prognostic value in a breast cancer cohort.

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma

This study shows that a small molecule Pfn1 inhibitor reduces tumor angiogenesis in renal cell carcinoma by targeting endothelial cell Pfn1.

Endothelial Rho kinase controls blood vessel integrity and angiogenesis

This study investigates the role of endothelial Rho kinase (ROCK1/2) in vascular integrity and angiogenesis, finding that their loss leads to vascular defects and lethality.

Alternate VEGFA isoform expression in fibrosarcoma leads to plasticity in cellular migration and differences in sensitivity to inhibition with anti-VEGFA antibodies

This study shows that VEGFA120 expression in fibrosarcoma cells promotes ECM remodeling and increases sensitivity to anti-VEGFA antibodies, while VEGFA188 does not.

ACE2 Phosphorylation Modulates Angiogenesis via the Activator Protein-1

This study shows that ACE2 phosphorylation at Ser-680 modulates angiogenesis by affecting AP-1 activation in vascular endothelial cells.

TRAP seq in 3D Angiogenesis Assays Reveals a Distinct Endothelial Translatome Associated with Early and Late Stages of Morphogenesis.

The paper uses TRAP seq in 3D angiogenesis assays to identify endothelial-specific gene expression changes during early and late stages of morphogenesis.

An Assessment of the Functional State of Endothelial Colony Forming Cells from Patients with Diabetes Mellitus and Chronic Limb Threatening Ischemia

This study assesses the functional state of endothelial colony forming cells (ECFCs) in patients with chronic limb threatening ischemia (CLTI) with and without diabetes, finding increased ECFC frequency in CLTI patients and no significant functional differences between groups.

Non-integrating direct reprogramming generates therapeutic endothelial cells with sustained vascular regeneration capacity enhanced by nanomatrix delivery

This study generates therapeutic endothelial cells from fibroblasts using non-integrating adenoviral ETV2 and enhances their long-term engraftment with nanomatrix delivery, showing sustained vascular regeneration in a mouse model.

Endothelial-pericyte interactions regulate angiogenesis via VEGFR2 signaling during retinal development and disease

This study shows that endothelial-pericyte interactions regulate angiogenesis through VEGFR2 signaling, and inhibiting VEGFR2 improves vascular stability in retinal diseases.

CYB5R4 sustains endothelial proliferation and ischemia-induced angiogenesis by maintaining RRM2-dependent nucleotide balance

This study identifies CYB5R4 as a regulator of endothelial proliferation and ischemia-induced angiogenesis through RRM2-dependent nucleotide balance.

VEGFR2 blockade overcomes acquired KRAS G12D inhibitor resistance driven by PI3Kγ activation

This paper identifies VEGFA-VEGFR2 signaling driven by PI3Kγ activation as a mechanism of acquired resistance to KRAS G12D inhibitors and shows that blocking this pathway restores drug sensitivity in resistant cancer models.

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

Deciphering the Origin and Plasticity of Circulating Endothelial Cells: A Model for Systemic Angiogenesis Programs in Health and Disease

This study identifies and characterizes circulating endothelial cells (CECs) using single-cell data, revealing their diverse origins and plasticity, and links them to angiogenic programs in cancer.

Mechanistic computational modeling of sFLT1 secretion dynamics

The paper develops a mechanistic model of sFLT1 secretion dynamics, showing that a delay differential equation system best fits experimental data and identifies key constrained parameters.