Alzheimer's disease research and treatments

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer's Disease Mice

This study identifies TRIM9 as a sex-specific regulator of the Aβ42/PrPC/mGluR5 complex in male Alzheimer's mice, linking it to pathological signaling and autophagy.

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

This study shows that reducing tau mitigates transcriptomic and behavioral issues in an Alzheimer's model without affecting amyloid levels.

Recombinant sialylated ApoE2 suppresses ApoE4 and sex-specifically strengthens brain metabolism and cognition in ApoE4 mice

This study shows that recombinant sialylated ApoE2 improves brain metabolism and cognition in ApoE4 mice, with sex-specific effects.

Tau spreading coordinates intercellular lipid flux enhancing neuronal resilience to lipid toxicity

This study shows that spreading tau coordinates lipid homeostasis by promoting neuronal lipid efflux and enhancing resilience to lipid toxicity.

Kinase-specific phosphorylation of tau outside the amyloid core encodes fibril fold selection

The paper shows that ERK2 phosphorylation of tau outside the amyloid core directs fibril formation into an Alzheimer's disease-like structure.

Reducing CETP activity prevents memory decline in an Alzheimer's disease mouse model

The paper shows that reducing CETP activity in Alzheimer's disease mice prevents memory decline and alters lipid and gene expression profiles, supporting CETP as a therapeutic target.

Identification of chemicals targeting dementia genes and pathways using the Comparative Toxicogenomics Database

The paper identifies chemicals enriched for dementia-related genes and pathways using the Comparative Toxicogenomics Database, finding many chemicals associated with Alzheimer's disease and tauopathies.

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau

This paper develops a scalable human neuronal model of 4R tauopathy with endogenous seed-competent tau for drug discovery.

Age-dependent brain proteome remodeling links Abca7 deficiency to insulin signaling and neuroinflammation in Alzheimers disease mice

This study identifies age-dependent proteomic changes in Abca7-deficient mice linked to insulin signaling and neuroinflammation, with overlaps in human Alzheimer's disease proteomics.

Errors in peptide synthesis are a source of discrepancies in Aβ42 studies

This study shows that sequence imperfections in synthetic Aβ42 peptides cause differences in aggregation behavior compared to recombinant Aβ42.

Computational Modeling of Functionalized Graphene Quantum Dots Binding to Tau Fibrils in Alzheimers Disease

This study investigates how functionalized graphene quantum dots (GQDs) bind to Tau fibrils in Alzheimer's disease, identifying binding sites and showing that anionic GQDs preferentially bind to specific regions, potentially aiding in TA disaggregation.

N-terminal Chirality and Sequence Variations Modulate the Conformational Landscape of Amyloid-beta 42

This study investigates how N-terminal chirality and sequence variations affect the conformational landscape of A{beta}42, finding that certain mutations and chiral modulations influence the central hydrophobic core and may have protective or pathogenic effects.

Oral administration of 1,10-phenanthroline-5-amine (PAA) significantly reduced amyloid plaque burden compared with untreated APP/PS1 mice.

This study validates that oral PAA reduces amyloid plaque burden in APP/PS1 mice and shows PAA directly binds to amyloid plaques in vitro.

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease

The paper identifies mitochondrial plaques in Alzheimer's disease by showing their presence in AD mouse models and human brains, linking them to mitophagy dysfunction and lysosomal impairment.

Early Amyloid-β Toxicity Disrupts Nervous System Connectivity During Aging in Caenorhabditis elegans

This study shows that early amyloid-β toxicity disrupts neuronal connectivity and function in C. elegans, distinct from normal aging, and identifies metabolic pathways involved in the effects.

Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice

This study shows increased Nav1.3 expression in early-stage 5xFAD mice leads to CA3 hyperexcitability, suggesting Nav1.3 as a target for AD intervention.

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts

This paper evaluates cross-ancestry polygenic risk scores (PRS) for Alzheimer's disease across multi-ethnic populations, finding improved predictive accuracy in non-European groups.

Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer's disease

This paper identifies a stage-specific proteomic signature of Alzheimer's disease using plasma proteomics and finds a proteomic switch associated with disease progression.

Carbonyl stress primes the metastable aging brain for Alzheimer's disease

The paper uses spatial transcriptomics and proteomics to show that Alzheimer's disease inflammation peaks in white matter, driven by lipid and carbonyl stress, and is linked to cognitive decline.

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunction

This study uses a humanized Aβ mouse model to show that E4 genotype leads to cognitive impairments, microglial activation, and cerebrovascular dysfunction, with greater effects in females.

Nanoscopic tau aggregates in Parkinson's disease

This study uses SiMPull to detect nanoscopic tau aggregates in PD brain regions, finding high-intensity aggregates in some PD cases despite negative IHC results.

Ms4a4a loss reprograms amyloid-associated microglia and limits dense-core plaque-associated tau spreading

This study shows that loss of Ms4a4a remodels microglial transcriptional programs and reduces dense-core plaque-associated tau spreading in a mouse model of Alzheimer's disease.

Dynamic Temporal Changes in Urinary Proteome of Pregnant Wild-Type Mice Carrying Heterozygous 3xTg-AD Fetuses

This study identifies dynamic urinary proteomic changes in pregnant mice carrying AD-susceptible fetuses, revealing early molecular responses to paternal AD mutations.

The diversity of disease-associated natural human antibody specificities declines dramatically in Alzheimers disease.

The paper investigates antibody specificity diversity in Alzheimer's disease and finds a 26-fold decline in diversity compared to cognitively normal individuals, with specific epitopes linked to amyloid proteins.

Krüppel-like factors KLF5 & KLF8 emerge as potential master transcriptional regulators of Alzheimer's disease, as revealed on cell fate regulomes in human brain organoids

The paper identifies KLF5 and KLF8 as master transcriptional regulators in Alzheimer's disease using human brain organoids and gene regulatory network analysis.

Ultrastructural remodelling of tau fibrils during ghost tangle formation in Alzheimer's disease brain

This study uses correlative light and electron microscopy to characterize the ultrastructural changes in tau fibrils during ghost tangle formation in Alzheimer's disease brain tissue.

Simulations of an extended Tau/tubulins interface reveal a complex disorder-disorder interplay mediated by the C-terminal tails

The paper uses molecular dynamics simulations to study the dynamic interactions between Tau protein and tubulin C-terminal tails, revealing sequence-dependent effects and disorder-disorder interplay.

MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer's Disease

This study shows that miR-223 improves cognitive function and reduces amyloid beta plaques in an Alzheimer's mouse model by enhancing microglial clearance.

Persistent microbial material contributes to Alzheimer disease and is targetable by vaccination

This study identifies persistent microbial material as a contributor to Alzheimer disease and shows that vaccination targeting it can improve cognition and reduce pathology.

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease

The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.