Neuroinflammation and Neurodegeneration Mechanisms

Interleukin-34 Promotes Activation of Disease-associated Microglia-like Cells and Attenuates Disease Progression in West Nile Virus Infection

This study shows IL-34 promotes DAM-like microglial activation and protects against WNV infection in cell culture and mice.

Clusterin regulates microglial inflammation and cognitive function independent of amyloid pathology in Alzheimer's disease

Minocycline engages microglia in the midbrain periaqueductal grey to attenuate hypoxia-triggered panic-like behaviour in rats

This study shows that minocycline reduces panic-like behavior in rats exposed to hypoxia by preventing microglial morphological changes in the midbrain periaqueductal grey.

Phage Display-Derived Cyclic Peptides Target TREM2 and Modulate Microglial Responses under Amyloid Stress

This study identifies cyclic peptides that bind TREM2 and modulate microglial responses under amyloid stress, suggesting their potential as neuroimmune therapeutics.

Transcriptional regulation of disease-relevant microglial activation programs

The paper identifies regulators of microglial activation states using CRISPR screens and single-cell transcriptomics, revealing functional roles of ZNF532, PRDM1, and DNMT1 in disease-associated microglial states.

Progranulin deficiency perturbs lipid metabolism in white matter microglia

This study shows that PGRN deficiency in microglia affects lipid metabolism, including reduced BMP and PE and increased GalCer, with age-dependent changes in Grn KO mice.

Gp130 Orchestrates a Bidirectional Neuron-Microglia Circuit for neuroprotection

This study identifies gp130 as a key receptor for a bidirectional neuron-microglia circuit that enhances neuroprotection after CNS injury.

Microglia extract neuronal proteolytic organelles via skoupocytosis

The paper shows microglia extract proteolytic organelles from neurons via a process called skoupocytosis, which bypasses retrograde transport and aids neuronal homeostasis.

Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-beta clearance in Alzheimer's disease models

This study shows diesel exhaust particles impair microglial function and amyloid-beta clearance in both mouse and human models, potentially contributing to Alzheimer's disease progression.

A roadmap for enriching rare cell populations from human post-mortem brain, demonstrated by 100% microglial purity.

The paper presents a method to isolate rare cell populations from human post-mortem brain with high purity, demonstrating 100% microglial purity using fluorescence-activated nuclear sorting.

iPSC-Derived Microglia-like Cells Exhibit Protocol-Dependent Transcriptomic Features and Robust Phagocytosis of Glioma Cells

The paper compares iMG differentiation protocols and finds protocol-dependent transcriptomic differences and phagocytic activity against glioma cells.

Microglia from Friedreich Ataxia patients are intrinsically primed for neuroinflammation

This study shows that microglia from Friedreich Ataxia patients have an intrinsic pro-inflammatory phenotype due to FXN deficiency, identifying potential therapeutic targets.

The brain-meningeal interface functions as a reservoir and entry site for brain parenchymal macrophages

The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.

Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease

This study identifies glycogen metabolism as a key regulator of microglial function in Alzheimer's disease, showing that glycogenolysis drives microglial activation and that inhibiting it reduces Abeta uptake and functional impairment.

A eutherian-specific metaviral gene, RTL6, coordinates microglial inflammatory responsiveness and state regulation

This study identifies RTL6 as a eutherian-specific gene that regulates microglial inflammatory responses and functional state transitions through its role in LPS signaling.

Single-cell gene networks nominate IKZF1 as an Alzheimer's microglial regulator

The paper identifies IKZF1 as a key microglial transcription factor in Alzheimer's disease using single-cell data and virtual screening, with potential drug repurposing candidates.

Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes

This study identifies Ackr3 as a regulator of astrocyte-mediated synaptic removal in disease, showing its role in synapse engulfment and its upregulation in Alzheimer's disease.

Plaque-associated Microglial Polarization in Visual Brain Regions of the 5xFAD Mouse Model

The paper examines Aβ pathology and microglial responses in visual brain regions of 5xFAD mice, finding significant Aβ accumulation and microglial polarization in image-forming regions but not in non-image-forming regions.

Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer's disease lipid-processing microglia

The paper identifies candidate regulators and signaling axes in Alzheimer's disease lipid-processing microglia through multi-omics analysis across multiple cohorts.

PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain

This study investigates the effects of PLCγ2 deficiency in mice, showing impaired immune tolerance, myelin homeostasis disruption, and enhanced oxidative metabolism in the brain.

Genetic context alters central nervous system compartment dependent responses to lipopolysaccharide

The paper examines how genetic and tissue-specific factors influence the neuroinflammatory response to LPS in different brain regions of mice.

FcγR- and CD9-dependent synapse engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage

The paper shows that thalamic microglia engulfing synapses, driven by CD9 and FcγRIII signals, cause cognitive impairment after cortical injury.

The lncRNA Gm16685/MITA1 modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signaling

The paper identifies Gm16685/MITA1 as a lncRNA that regulates astrocyte reactivity through PCBP2-mediated modulation of IKKβ signaling in inflammatory conditions.

Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation

The paper characterizes myeloid cell populations at the cribriform plate during EAE-induced neuroinflammation, finding they exhibit tolerance and reduced inflammatory profiles.

Apolipoprotein E governs neuroinflammation resolution and recovery from viral encephalitis

This study identifies Apolipoprotein E as a key driver of neuroinflammation resolution and recovery from viral encephalitis using a mouse model and patient data.

Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

Linking Systemic Endotoxin Exposure to Retinal Microglia Migration Through Mathematical Modeling

This study develops a mathematical model to simulate retinal microglia migration during inflammation, showing that LPS delivery route and species-specific pharmacokinetics drive redistribution patterns.

Microbiome-derived Short Chain Fatty Acids modulate microglial inflammatory responses in a sex- and metabolite-specific manner

This study shows SCFAs modulate microglial inflammation differently in males and females, with butyrate strongly affecting gene expression and histone acetylation.

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson's disease tissue

This study uses snRNA-seq data from post-mortem Parkinson's disease tissue to identify altered molecular pathways in microglia and astrocytes, showing upregulated protein misfolding responses and downregulated inflammation-related genes.

Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT-S305N model of frontotemporal dementia.

The paper compares two iPSC-microglia protocols to assess how the MAPT-S305N mutation affects microglial function and neuronal health in a frontotemporal dementia model.