interferon and immune responses

A tissue-scale strategy for sensing threats in barrier organs

The paper uses single-molecule imaging and spatial transcriptomics to show a spatially graded threat-sensing strategy in lung tissue during influenza infection, with higher PRR expression in inner stroma leading to more potent immune responses.

MNS induces antiviral protection and suppresses inflammation

This study shows that MNS reduces viral infection and inflammation in cell and animal models by suppressing inflammatory pathways and altering chromatin accessibility.

Gene regulatory networks define human airway epithelial cell types and their distinct responses to type I interferon

The paper characterizes gene regulatory networks in human airway epithelial cells and identifies cell type-specific responses to type I interferon.

Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium

This study shows that IFNE expression decreases in infants, leading to reduced antiviral activity against RSV, suggesting a role in early-life RSV susceptibility.

Loss of 7-Dehydrocholesterol Reductase-mediated cholesterol biosynthesis activates IRF3 and inhibits control of Mycobacterium marinum infection

This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.

The enteroviral protease target LSM14A operates outside of P-bodies to augment antiviral innate immunity

This study identifies LSM14A's role in antiviral immunity independent of its localization to P-bodies and peroxisomes, revealing a specialized interaction network that enhances innate immune signaling.

IFI207 promotes antiviral responses by modulating STING ubiquitination and degradation

This study shows IFI207 modulates STING ubiquitination and degradation, enhancing antiviral responses against MLV and herpesvirus simplex 1.

ASFV early protein p30 suppresses antiviral type I IFN induction by targeting TRIM21 and RIG-I like receptor signaling adaptor MAVS

This study identifies ASFV p30's role in suppressing antiviral type I IFN induction by interacting with TRIM21 and MAVS, disrupting TRIM21-mediated K27 polyubiquitination of MAVS.

Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling

This study shows that MTPAP loss causes mitochondrial RNA processing defects, leading to type I interferon signaling upregulation through mt-dsRNA accumulation.

Influenza A virus NS1 sequesters RNA:DNA hybrids to evade RNase H1-dependent innate immunity

Constitutive Interferon Epsilon Expression Shapes Antiviral Epithelial States in the Female Reproductive Tract and Intestine

This study identifies IFN{varepsilon} as a constitutively expressed IFN that maintains antiviral defenses in the female reproductive tract and intestine by sustaining specific epithelial states and type III IFN expression.

A genetically encoded reporter reveals coordinated interferon responses in neurons and non-neuronal cells in the brain

The paper develops a genetically encoded reporter to detect IFN responses in brain and peripheral tissues, revealing coordinated responses in neurons and non-neuronal cells across various conditions.

Cell morphology deep learning guides discovery of mitochondrial host defense against influenza

The paper uses deep learning on organelle images and chemoproteomics to identify mitochondrial proteins involved in antiviral defense against influenza.

Locus-specific Convergent Evolution and Interchromosomal Rearrangements Contribute Type I Interferon Diversification in Amniotes

The paper identifies conserved IFN-I loci and lineage-specific expansions in amniotes, revealing convergent evolution and interchromosomal duplications contributing to IFN-I diversity.

The long isoform of ZAP coordinates multiple enzymes to mediate complete decay of target transcripts

This study identifies how the long ZAP isoform recruits enzymes to degrade viral RNA through a coordinated decay pathway.

Glutamate transporter xCT is important for cGAS-dependent interferon responses to DNA and to HSV-1

This study shows that the xCT transporter regulates cGAS-dependent interferon responses to DNA and HSV-1 by controlling glutamate levels and cGAMP production.

Detailed single-cell mapping of the transcriptional response to a virus infection driven by copy-back viral genomes

The paper uses single-cell RNA-sequencing to study how copy-back viral genomes drive host cell responses during Sendai virus infection, revealing dynamic transcriptional changes over time.

Human macrophages secrete both interferon α and interferon β protein during infection with Mycobacterium tuberculosis.

This study shows human macrophages secrete both interferon α and β during Mtb infection, challenging previous assumptions about their kinetics and timing.

It's Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages

This paper identifies a pathway where dopamine induces mitochondrial dysfunction in macrophages, leading to IL-6 secretion via the cGAS-STING pathway.

A Stable Reporter Cell Line to Study Respiratory Syncytial Virus NS2-Mediated Inhibition of IFNB Promoter Activation

The paper develops a stable reporter cell line to quantify NS2-mediated inhibition of IFNB promoter activation in RSV infection.

Coronavirus Nucleocapsid Proteins Hijack Host Protein Kinase A Catalytic Subunit α into Nucleus to Evade from STAT1 Signaling

This study shows coronavirus N proteins bind and sequester PKA C into the nucleus to block STAT1 activation, evading antiviral responses.

Cellular senescence dysregulates antiviral interferon responses in idiopathic pulmonary fibrosis

This study shows that cellular senescence in IPF fibroblasts disrupts antiviral responses, leading to increased viral titers and altered inflammation.

Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity

This study identifies GBP5 as a key antiviral gene in bats, showing its evolutionary adaptations and functional specificity in restricting viral infections.

Type I interferons induced upon respiratory viral infection impair lung metastatic initiation

This study shows that type I interferons from respiratory viral infections reduce lung metastasis by altering the lung environment and impairing tumor cell growth.

The type I and III interferon responses restrict infection with tick-borne orthoflaviviruses through IFI6

This study identifies IFI6 as a key antiviral effector mediating type I and III interferon restriction of tick-borne orthoflaviviruses in human cells and mice.

STING suppresses migration of murine triple-negative breast cancer cells E0771 and 4T1 in vitro

This study shows STING overexpression suppresses migration of murine TNBC cells without affecting proliferation.

Keratin 16 spatially inhibits type I interferon responses in stressed and diseased skin

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

Hypoxia inducible factors regulate Pneumovirus replication by enhancing innate immune sensing

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation.

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

Sustained interferon exposure creates a hyper-metastatic subset of melanoma cells

Sustained interferon exposure in inflamed tumor regions enhances metastatic potential of melanoma cells via increased CD47 expression, protecting them from macrophage phagocytosis.