interferon and immune responses

The human DEAD-box protein DDX3X regulates host and viral mRNA translation during Sendai Virus infection

This study identifies DDX3X's role in regulating host and viral mRNA translation during Sendai Virus infection, revealing its direct interaction with IFNB1 5'UTR and its impact on IFN-β production.

Key role of TLR3 in type I IFN expression and apoptosis induction in IBDV-infected chicken fibroblast cells

This study shows that TLR3 is essential for IBDV-induced apoptosis and IFN production in chicken fibroblasts, and its absence enhances viral replication.

Essential role of hsa-miR-203a-3p in type I Interferons immune homeostasis during Influenza and NDV infection

This study identifies miR-203a-3p as a regulator of type I interferons that promotes viral replication by suppressing interferon-stimulated genes during influenza and NDV infection.

ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

This study shows ZNFX1 uses a two-component ubiquitin circuit to trap viral RNA, linking its function to antiviral immunity.

Cutaneous human papillomavirus E6 impairs the cGAS-STING pathway

This study shows that {beta}-HPV 8 E6 impairs the cGAS-STING pathway, reducing innate immune responses to micronuclei and promoting cell proliferation.

The antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction

This study shows APOL3 links lysosomal damage to mitochondrial DNA release and type I IFN production via BAK/BAX pores and cGAS/STING signaling.

Terminal Loop Sequences in Viral Double-Stranded RNAs Modulate RIG-I Signaling

The paper shows that terminal loop sequences in viral double-stranded RNAs enhance RIG-I signaling and IFN expression, with synthetic versions triggering innate immune responses in mice.

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

This study shows DGCR8 suppresses endogenous dsRNA from TEs to prevent IFN response activation, with implications for 22qDS.

Cytosolic DNA structures produced by mismatch-repair deficiency coordinate anti-tumor immunity in colorectal cancer

The paper identifies cytosolic DNA structures in MSI CRC that enhance STING activation and anti-tumor immunity, suggesting potential for improved DNA-based therapies.

Golgi-localised Guanylate-binding protein 5 enhances glycolysis in macrophages

This study identifies GBP5's role in enhancing glycolysis and maintaining Golgi integrity in IFNγ-stimulated macrophages.

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3

The paper investigates IFN-β induction heterogeneity during KSHV infection and finds that ATF2 and RelA, not IRF3, correlate with IFN-β production.

Chicken IRF10 suppresses the cGAS-STING-IFN antiviral signaling pathway by targeting IRF7

This study identifies chIRF10 as a suppressor of chicken cGAS-STING-IFN antiviral signaling by inhibiting chIRF7 activation and dimerization.

Regulation of STING activation by phosphoinositide and cholesterol

This study identifies phosphoinositides and cholesterol as regulators of STING activation by promoting its oligomerization and translocation.

Cryo-EM structures of SAMD9L reveal the arrangement and coordination of multi-domains

This study determines the cryo-EM structures of hSAMD9L and an N-terminal-truncated mutant, revealing their multi-domain architecture, dimerization, and nucleotide binding properties.

p300/CBP-Driven Acetylation Stabilizes PARP7 to Reinforce Negative Feedback on IFN-I Signaling

This study identifies p300/CBP-mediated acetylation of PARP7 as a mechanism to suppress IFN-I signaling in tumor cells, with implications for enhancing antitumor immunity.

Microbiota-dependent IFN-L controls uterine and placental immunity.

This study identifies IFN-L as a microbiota-dependent regulator of uterine immunity, controlling both immunoregulation and antibacterial responses during pregnancy.

Interferon lambda signaling to maternal dendritic cells protects against congenital Zika virus infection

This study shows that maternal IFN-lambda signaling to dendritic cells reduces transplacental ZIKV transmission in mice.

Type I IFN dynamics define an early checkpoint for survival and orchestrate systemic neutrophil heterogeneity in lethal viral infection

VPS34-IN1 inhibits cap-mediated translation and synergizes with STING to drive type-I IFN expression in human plasmacytoid DCs

VPS34-IN1 inhibits cap-mediated translation and enhances STING-driven type-I IFN expression in human plasmacytoid DCs by altering SGK3 recruitment and STING degradation.

CASM potentiates STING-driven NFκB signaling in immune cells

The paper investigates the role of CASM in STING signaling, finding that CASM enhances NFκB-driven TNF production while autophagy exerts negative feedback on STING pathways.

Dimerization-dependent gel-like condensation with dsDNA underpins the activation of human cGAS

This study shows that cGAS dimerization on dsDNA forms gel-like condensates, which activate cGAS and protect dsDNA, while single-stranded RNA can dissolve these condensates.

ISG15 orchestrates dynamic crosstalk between mitochondrial fat oxidation and type 1 interferon in myeloid cells

This paper identifies a biphasic regulatory loop where type 1 interferon initially enhances mitochondrial fatty acid oxidation (FAO) to amplify its own production, but excessive IFN signaling induces ISG15-mediated inhibition of FAO, creating a negative feedback loop to control inflammation.

CREG1 restricts ALV-J replication via the mitochondrial dysfunction-driven activation of innate immunity and apoptosis

This study identifies CREG1 as a host factor that restricts ALV-J replication by inducing mitochondrial dysfunction and activating innate immunity and apoptosis.

A novel ISG15 transcript restricts influenza A virus infection

The paper identifies a novel ISG15 transcript that restricts influenza A virus infection through a distinct mechanism independent of its cytokine function.

Poly(A)-tail-length-dependent surveillance of viral RNA by PABPC1 orchestrates broad-spectrum antiviral defense

This study identifies PABPC1 as a host factor that selectively targets viral RNA with short poly(A) tails, leading to degradation and antiviral defense, and develops a synthetic therapeutic based on this mechanism.

Nonsense-mediated decay controls a negative feedback loop in innate immune sensing

The paper shows that dsRNA sensing inhibits NMD, forming a negative feedback loop that limits dsRNA-mediated immune responses.

Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature

This study identifies ISG20 as an antiviral factor against HCMV by inducing an innate immune defense signature that enhances IFN production and response.

An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.

This study identifies a mutation that suppresses SAVI phenotypes in MITA/STING gain-of-function mutants and proposes a therapeutic strategy using a peptide inhibitor.

Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis

This study shows that fever during influenza A virus infection increases antiviral signaling by promoting aberrant RNA synthesis and innate immune activation.