Barrier Structure and Function Studies

Meningeal inflammation and arachnoid barrier breakdown in a mouse model of neonatal bacterial meningitis

This study shows that GBS infection increases arachnoid barrier permeability in neonatal mice, driven by cytokine production from fibroblasts and macrophages.

APOE4 Genotype is Associated with Reduced Cortical VEGFR2 (KDR) Transcript Levels Independent of Endothelial Abundance: An AMP-AD RNA-seq Pilot Study

This study finds that APOE4 genotype is associated with reduced KDR transcript levels in cortical brain tissue, independent of endothelial cell abundance and neuropathological factors.

NimA promotes cell adhesion at the blood brain barrier of Drosophila nervous system

The paper identifies NimA as a glial-specific protein in Drosophila that regulates cell adhesion at the blood-brain barrier, essential for BBB integrity and neural development.

Blood-brain barrier dysfunction predicts cognitive trajectory after ischemic stroke

The paper identifies a plasma proteomic signature linked to blood-brain barrier dysfunction, which predicts cognitive decline after ischemic stroke.

LACK OF OXYGEN AND/OR GLUCOSE DIFFERENTIALLY POTENTIATES Aβ40E22Q- AND Aβ42-INDUCED CEREBRAL ENDOTHELIAL CELL DEATH, BARRIER DYSFUNCTION AND ANGIOGENESIS IMPAIRMENT

This study shows that hypoxia and glucose deprivation enhance Aβ40E22Q- and Aβ42-induced cerebral endothelial cell death, barrier dysfunction, and angiogenesis impairment.

Panax notoginseng saponins protect the blood brain barrier against oxidative stress by activating the Akap12/PI3K/AKT/AQP1 signaling axis

This study shows that Panax notoginseng saponins protect the blood-brain barrier from oxidative stress by activating the Akap12/PI3K/AKT/AQP1 signaling pathway and modulating tight junction proteins.

Extracellular methylglyoxal; the passage across brain endothelial cells and the effect on barrier function

This study investigates whether methylglyoxal (MGO) crosses the blood-brain barrier (BBB) in vivo and affects BBB permeability in vitro, finding no significant MGO passage or barrier disruption.

Caveolin-1 Mediated Blood-brain Barrier Transcytosis Promotes Porphyromonas gingivalis Invasion and Alzheimer's Disease-Like Changes

This study shows that a leaky blood-brain barrier, mediated by caveolin-1 transcytosis, allows Porphyromonas gingivalis to enter the brain, leading to Alzheimer's disease-like changes.

Light-driven repair: Photobiomodulation restores blood brain barrier function following hypoxic injury

This paper shows that photobiomodulation (PBM) restores blood-brain barrier (BBB) function after hypoxic injury by modulating endothelial signaling and reducing oxidative stress in glial cells.

Vascular Basement Membrane Laminins Modulate Functional Zonation of Cerebral Microvessels

This study shows that vascular basement membrane laminins regulate cerebral microvessel functional zonation by modulating endothelial and mural cell identity and vascular permeability.

Mesenchymal Stromal Cell Therapeutic Potential to RestoreNeurovascular Integrity in Machado-Joseph Disease

This study evaluates the therapeutic potential of mesenchymal stromal cells (MSC) in mitigating vascular abnormalities and blood-brain barrier (BBB) disruption in Machado-Joseph disease (MJD) transgenic mice, showing partial restoration of vascular and BBB integrity.

Forward Programming Identifies Inducers of Blood-Brain Barrier Properties in Human Pluripotent Stem Cell-Derived Endothelial Cells

The paper identifies transcription factors that induce BBB properties in human pluripotent stem cell-derived endothelial cells through forward programming.

Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based model

This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.

Programming of Embryonic Blood Brain Barrier and Neurovascular Transcriptome by an Anticipatory Acoustic Signal of Heat in the Zebra Finch

This study identifies transcriptomic changes in zebra finch embryos exposed to prenatal acoustic heat calls, revealing anticipatory programming of the neurovascular system to enhance heat resilience.

Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow

This paper presents a scalable 3D BBB model using human cells in a microfluidic platform, showing improved barrier function with co-culture of endothelial cells, astrocytes, and pericytes.

Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming and increased inflammation in the aging brain

This study identifies a transcriptomic signature in aged brain endothelial cells linked to lipid accumulation, BBB dysfunction, metabolic changes, and inflammation.

Human iPSC-derived CNS and retinal microvasculature-on-a-chip models recapitulate hallmarks of diabetic microvascular pathology

This study develops human iPSC-derived microvascular models to study diabetic microvascular pathology and identifies inflammatory pathways involved in vascular damage.

Glial betaPix is essential for blood vessel development in the zebrafish brain

This study identifies betaPix's role in glial cells for vascular development and blood-brain barrier formation in zebrafish embryos.

Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells

The paper shows that bacterial extracellular vesicles disrupt a BBB on-chip model indirectly via immune cell activation, not directly through BMEC damage.

ENDOTHELIAL PROX1 INDUCES BLOOD-BRAIN BARRIER DISRUPTION IN THE CENTRAL NERVOUS SYSTEM

This study shows that endothelial Prox1 overexpression disrupts the blood-brain barrier by downregulating BBB-associated genes and Wnt/β-catenin signaling during both embryonic and postnatal stages.

The effects of Alcohol Dependence on the CSF Proteome in Mice: Evidence for Blood-Brain Barrier Dysfunction and Neuroinflammation

This study uses proteomics to compare CSF from alcohol-dependent and non-dependent mice, identifying molecular changes linked to BBB dysfunction and neuroinflammation.

Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier

This study uses proteomic profiling to identify age-related changes in transporter proteins in human brain microvessels, revealing alterations in BBB permeability and drug disposition.

Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP2 regeneration and activation of Kir2.1 channels.

This study shows that Arf6 maintains PIP2 levels in capillary endothelial cells, sustaining Kir2.1 channel activity and functional hyperemia, and identifies Arf6 as a therapeutic target for cerebral blood flow restoration.

Fully Human Stem Cell-Derived BBB Model for Clinical Disease Modeling and Neurotropic AAV selection

This paper develops a fully human stem cell-derived BBB model to study disease mechanisms and evaluate neurotropic AAV capsids.

Evaluating Microglial Contributions to the Neurovascular Unit in Health and Neurodegeneration Using Human In Vitro Models

This study develops 2D and 3D human in vitro neurovascular unit models to investigate microglial interactions with endothelial cells and their role in neurovascular function under inflammatory conditions.

Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short-Chain Fatty Acid Butyrate

This study shows butyrate reduces Aβ42 and TNF-α-induced VCAM-1 expression in BBB endothelial cells by modulating the STAT3/GATA6 axis.

Two-photon microscopy of brain endothelial glycocalyx uncovers spatial heterogeneity, vesicular transport, and lectin-binding kinetics in the living brain

This study uses two-photon microscopy to reveal structural and dynamic features of the brain endothelial glycocalyx, including spatial heterogeneity, vesicular transport, and lectin-binding kinetics in vivo.

Occludin Acts as a Dynein Adaptor Regulating Permeability and Collateral Angiogenesis

This study identifies occludin's role as a dynein adaptor regulating vascular permeability and collateral angiogenesis through phosphorylation-dependent trafficking.

A Machine Learning- 3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial Integrity.

This paper develops a 3D human brain endothelial platform combined with machine learning to identify kinase inhibitors that restore blood-brain barrier integrity in TBI.

A novel human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion

This study develops a human BBB model using NCC-PCs to show they protect against viral neuroinvasion by maintaining BMEC barrier integrity.