Neurogenesis and neuroplasticity mechanisms

A conserved logic for the development of cortical layering in tetrapods

The paper shows that cortical layering in tetrapods follows conserved developmental principles, with mammals displaying an inverted layer order.

Hippo/YAP1 Signaling Regulates the Oligodendrocyte-Astrocyte Fate Switch and Ependymal Gene Expression in Adult Spinal Cord Stem Cells

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis

This study identifies AGO1's role in neural progenitor cells in brain development and sociability through the LIN28A-REELIN axis, showing its impact on ASD-related phenotypes.

Polysialic Acid Presentation on Microporous Scaffolds Supports Neural Repair after Ischemic Stroke

This study shows that PSA-MAP scaffolds enhance early neural regeneration after ischemic stroke by increasing progenitor cells and axonal content without significant changes in astrocytic or vascular coverage.

Hypoxia preconditioned neural xenografts promote repair of brain tissue after stroke

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

Accelerated Tempo of Cortical Neurogenesis in Down Syndrome

This study shows that TS21 accelerates radial glia lineage progression, leading to premature production of inhibitory neurons and oligodendrocytes in Down syndrome.

miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer's disease

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

Altering cell size asymmetry in Drosophila neural stem cells creates supernumerary stem cells with limited lineage expansion potential

The paper investigates how altering cell size asymmetry in Drosophila neural stem cells affects their proliferation and lineage potential, finding increased stem cell pools but reduced lineage size and differentiation.

Epigenetic-metabolic axis in the temporal scaling of mammalian cortical neurogenesis across species

The paper identifies H3K27me3-mediated repression and -ketoglutarate as key regulators of species-specific neurogenesis timescales across mammals.

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth

This study shows that PSD-95 in oligodendrocytes is essential for activity-dependent myelin sheath growth through axon-oligodendrocyte connectivity in zebrafish.

Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis

This study identifies cortical tension as a mechanical barrier that prevents premature neuronal differentiation during neurogenesis, showing that reducing it accelerates neuronal lineage commitment and differentiation.

Characterization of adult hippocampal neurogenesis in the novel AppSAA Knock-in Alzheimer's disease mouse model

This study characterizes adult hippocampal neurogenesis in AppKI mice, showing age-related deficits and environmental enrichment's protective effect.

Cell-extrinsic controls over neocortical neuron fate and diversity

The paper investigates how environmental factors influence neocortical neuron fate and diversity through in vivo and in vitro experiments, showing population-specific responses and the importance of extracellular context.

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

Transcriptional dynamics of the oligodendrocyte lineageand its regulation by the brain erythropoietin system

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

Distinct Neurogenic Dynamics of Cortico-cortical Neuronal Subtypes in Layer 2/3 of the Mouse Visual Cortex

The paper investigates the relationship between neurogenic timing and cortico-cortical projection identity in mouse visual cortex layer 2/3, finding distinct birthdate patterns for lateral and medial projection subtypes.

Inhibition of the neurodevelopmental disorder-associated 16p11.2 gene QPRT leads to altered cell type distribution in human stem cell-derived cerebral organoids

This study inhibits QPRT in human stem cell-derived cerebral organoids, revealing altered cell type distribution and metabolic stress linked to neurodevelopmental disorders.

Dynamic regulation of NeuroD1 expression level by a novel viral construct during astrocyte-to-neuron reprogramming

This study introduces a viral construct that dynamically regulates NeuroD1 expression during astrocyte-to-neuron reprogramming, reducing its level in reprogrammed neurons to enhance GABAergic differentiation.

Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology

This study develops a method to generate neocortical organoids with distinct anterior-posterior molecular signatures and uses them to model Fragile X Syndrome pathology.

Adducins regulate morphology and fate of neural progenitors during neocortical neurogenesis

This study shows adducins regulate proliferation and fate of neural progenitors in mouse, ferret, and human neocortex, affecting neurogenesis.

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring via IFN-gamma responsive microglia

This study shows maternal SARS-CoV-2 vaccination increases hippocampal neurogenesis and working memory in offspring mice via IFN-gamma responsive microglia.

From injury to recovery: Functional neuronal regeneration after traumatic brain injury in the telencephalon of the young adult African turquoise killifish

This study investigates functional neuronal regeneration after traumatic brain injury in killifish, showing that new neurons integrate into circuits and enable behavioral recovery over 50 days.

Cortex Folding by Combined Progenitor Expansion and Adhesion-Controlled Neuronal Migration

The paper shows that combining progenitor expansion with adhesion-controlled neuronal migration enhances cortex folding in mice, leading to sulci and gyri formation.

Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with their reactivation routes and potential

The paper identifies molecular clusters of quiescent neural stem cells in zebrafish and shows how Notch signaling inhibition leads to distinct activation behaviors.

Species-specific Rates of Fatty Acid MetabolismSet the Scale of Temporal Patterning of Corticogenesisthrough Protein Acetylation Dynamics

This study shows that species-specific fatty acid oxidation rates influence temporal patterning of corticogenesis through protein acetylation dynamics in human and mouse cortical progenitors.

Developmental transformations of Purkinje cells tracked by DNA electrokinetic mobility

The paper uses stereo-tracking to study Purkinje cell development and identifies a new subcellular structure called axon bubbles.

FOXP Genes Regulate Purkinje Cell Diversity in Cerebellar Development and Evolution

The paper identifies Foxp genes as regulators of Purkinje cell diversity in cerebellar development and evolution, showing their role in subtype specification and species-specific cerebellar organization.

Reconstructing the Ischemic Cerebrum by Transplanted Human Neurons

This study shows transplanted human cortical neurons can integrate into and repair damaged motor circuits in ischemic mice by following transcriptional codes for axon guidance and synapse formation.

Neural Progenitors as a Novel Pathogenic Mechanism in Microcephaly

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

An increase in reactive oxygen species underlies neonatal cerebellum repair

This study shows that reactive oxygen species (ROS) increase in the neonatal cerebellum after injury, and reducing ROS impairs regenerative processes.