Genetics, Aging, and Longevity in Model Organisms

Modeling neurodegenerative diseases in Drosophila is conditioned by stress resistance and gut microbiome composition of the reference line

The paper shows that differences in stress resistance and gut microbiome composition between Drosophila reference lines affect disease modeling outcomes in neurodegenerative conditions.

Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

Hormetic nutrient stress promotes longevity by orchestrating histone acetylation on key lipid catabolism and antioxidant defense genes

This study identifies H3K27ac as a key transcriptional switch that promotes longevity by enhancing lipid catabolism and antioxidant defenses under hormetic nutrient stress in C. elegans.

InsP3R signaling mediates mitochondrial stress-induced longevity through actomyosin-dependent mitochondrial dynamics

This study identifies InsP3R signaling as a mediator of mitochondrial stress-induced longevity in C. elegans through actomyosin-dependent mitochondrial dynamics.

Analysis of the current state of frailty indexes and their implementation for aging intervention studies

This paper evaluates rodent frailty indexes and their implementation in aging studies, highlighting inconsistencies in frailty parameters and recommending standardized protocols.

Multiomic clocks to predict phenotypic age in mice

This paper develops a multi-omic model to predict phenotypic age in mice, showing it can predict remaining lifespan even among same-aged mice.

A Minimal Model Explains Aging Regimes and Guides Intervention Strategies

The paper introduces a minimal model of aging that predicts two regimes and guides intervention strategies for extending healthspan and lifespan.

Reserpine prolongs lifespan but compromises heat-stress resilience in Drosophila melanogaster

This study shows that Reserpine extends lifespan in Drosophila but reduces heat-stress resilience, revealing a trade-off between longevity and stress response.

Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging

This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

Refining the generation, interpretation, and application of multi-organ, multi-omics biological aging clocks

The paper develops and integrates multi-organ proteome-based biological age gaps (ProtBAGs) with phenotype-based age gaps to explore their genetic and clinical implications in aging and disease.

Cave Adaptation Favors Aging Resilience in the Mexican Tetra

The paper compares aging markers between surface and cavefish populations of Astyanax mexicanus, finding that cavefish show less pronounced aging signatures and suggest metabolic shifts, particularly mitochondrial function, contribute to their extended longevity.

Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D

The paper shows that gut microbiota in Drosophila affect ageing through Acetobacter, Tachykinin, and TkR99D, extending lifespan without reducing fecundity.

Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

This study shows that autophagy gene knockdown in C. elegans affects lifespan in a highly condition-dependent manner, with variable outcomes based on genetic background, temperature, and experimental conditions.

The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life

This study identifies DIMT-1 as a regulator of C. elegans lifespan and stress resistance through its role in rRNA methylation and germline function.

Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids

This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.

SkeletAge: Transcriptomics-based Aging Clock Identifies 26 New Targets in Skeletal Muscle Aging

The paper introduces SkeletAge, a bulk RNA-seq-based aging clock that identifies 26 novel genes in skeletal muscle aging and links them to aging phenotypes and drug targets.

Expression of the naked mole-rat transgene for Has2 improved health span in C57Bl/6 mice, but it did not attenuate age-related hearing loss.

This study expresses a naked mole-rat HA synthase 2 transgene in mice, finding improved healthspan but no reduction in age-related hearing loss.

Nuclear Hormone Receptor NHR-49/HNF4α Couples Fertility Regulation to Resource Allocation and Longevity in C. elegans

This paper identifies NHR-49 as a regulator of oocyte activation and ovulation in C. elegans, linking fertility, resource allocation, and longevity through its role in controlling GSA-1 expression.

Harnessing variation in Drosophila melanogaster reveals different routes to increased infection susceptibility over age and sex-dependent association with lifespan

This study examines age-related increases in infection susceptibility in Drosophila melanogaster, finding that susceptibility rises early in life and is linked to reduced tolerance rather than resistance, with distinct effects on male lifespan.

Dietary Zn governs protein: carbohydrate regulation of fecundity and lifespan in Drosophila melanogaster

This study shows dietary zinc and protein-to-carbohydrate ratio interact to regulate reproduction and lifespan in Drosophila, with Zn having effects comparable to macronutrient adjustments.

Molecular signatures of longevity identify compounds that extendmouse lifespan and healthspan

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

Genetic mapping of lifespan and mitochondrial stress response in C. elegans

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

daf-16/FOXO activity before dauer diapause anticipates dauer exit and post-dauer development via DAF-12/NHR

This study shows that daf-16/FOXO activity before dauer diapause enables dauer exit and post-dauer development by promoting cholesterol retention and DAF-12 ligand synthesis.

Mutation accumulation underpins evolution of lifespan extension by dietary restriction

This study shows that dietary restriction extends lifespan in C. elegans by suppressing fertility, not through adaptive hypotheses, and suggests mutation accumulation drives this evolutionary effect.

The Mediator complex subunit Med19 extends healthy lifespan in Drosophila by preventing cellular and organismal frailty

This paper shows that increasing Med19 in Drosophila extends lifespan by 90%, delays frailty onset, and improves stress resistance, while reducing Med19 shortens lifespan and increases vulnerability to stress.

Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans

This study shows that LSD extends lifespan and reduces age-related decline in C. elegans, suggesting it modulates conserved nutrient-sensing pathways linked to longevity.

Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and health span in C. elegans

The paper identifies metabolites from aged muscle that extend lifespan and improve health in C. elegans models of neurodegenerative diseases.

"Smurf Mice": revolutionising our understanding of age-related and end-of-life animal physiology

This paper validates a two-phase ageing model in mice, showing a phenotypic signature of imminent death across chronological ages.

Mouse peritoneal macrophages undergo female-specific remodeling with aging driven by both hormone-dependent and -independent mechanisms

This study identifies sex-specific aging-related changes in mouse peritoneal macrophages, driven by both hormone-dependent and -independent mechanisms.