Estrogen and related hormone effects

Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells

The paper shows that hormone response magnitude in mammary organoids and ER+ cancer cells varies independently of receptor abundance and follows distinct activation dynamics.

Antidepressants interact with sex steroid receptors and their intracellular signaling components

This study shows antidepressants interact with estrogen receptor alpha and its signaling pathways, suggesting a new mechanism for their therapeutic effects in mood disorders.

Androgen receptor interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer.

This study identifies cytoplasmic androgen receptor (AR) localization and novel AR protein interactions in AI-resistant breast cancer, linking them to metabolic shifts and poor prognosis.

Transcriptional Activation of Estrogen Receptor-alpha and Estrogen Receptor-beta from Elephant Shark (Callorhynchus milii)

The paper studies estrogen receptor activation in elephant shark, finding three active ER genes and one unresponsive gene, with similar estrogen responses to humans.

Glucocorticoid-induced proteome and phosphoproteome changes in breast cancer cell lines

This study uses mass spectrometry to analyze proteome and phosphoproteome changes in breast cancer cell lines after glucocorticoid treatment, revealing GR-dependent responses and noncanonical TFs and kinases involved in metastasis.

Hormone signaling and immune programs define differential endocrine responsiveness in high-risk breast tissue

The paper identifies hormone signaling and immune programs as factors determining endocrine responsiveness in breast tissue with background parenchymal enhancement.

Hepatocyte Estrogen Receptor α Mediates Estrogen-induced Augmentation of Hepatic 1 Mitochondrial Respiration Following Ovariectomy.

This study shows that estrogen receptor α in hepatocytes is necessary for estrogen to enhance mitochondrial respiration and reduce steatosis after ovariectomy.

Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function

The paper develops selective glucocorticoid receptor modulators (SGRMs) that modulate immune checkpoint function by altering GR activity states through structural design and machine learning.

Targeting Estrogen to the Brain via the Prodrug DHED does not Protect Against Metabolic Dysfunction in Obese, OVX mice.

This study tests if brain-targeted estrogen via DHED prodrug improves metabolic health in obese, ovariectomized mice, but finds no such benefit.

Genome wide analysis of YBX1-mediated redistribution of JMJD6 in ER+ breast cancer cells

The paper identifies a JMJD6-YBX1 transcriptional axis that reprograms chromatin and sustains tumor proliferation in ER+ breast cancer cells through enhancer redistribution and altered signaling pathways.

Single cell RNA-sequencing reveals an association between testosterone treatment and reduced hormone signaling in the human mammary gland

This study uses single-cell RNA sequencing to show that testosterone treatment reduces estrogen signaling in mammary gland cells of transgender men compared to cisgender women.

Selective estradiol sensitivity in 12Z human endometriotic epithelial cell line

This study investigates the responsiveness of the 12Z human endometriotic epithelial cell line to estradiol, finding it lacks functional sensitivity in most assays but shows selective response in 3D migration under confinement.

A novel dephosphorylation peptide inhibits 17β-HSD1 enzyme activity in ovarian granulosa cells and breast cancer cells

This study identifies phosphorylation sites in 17β-HSD1 and develops cell-penetrating peptides that inhibit its activity, reducing breast cancer cell proliferation and tumor growth.

Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour

This study shows that Egr1 overexpression induces sex-specific changes in neuronal chromatin, gene expression, and behavior in female rodents, mimicking high-oestrogenic phases and affecting hormone-depleted females.

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding states

This study shows hepatocyte ERα regulates sex-specific liver responses to fasting and feeding, affecting gene expression and metabolic pathways differently in males and females.

Chlorpyrifos and tamoxifen co-pretreatment promotes stem-like phenotype and upregulation of anti-estrogen therapy resistance markers in ERα breast cancer cells

Integrative Network Meta-Analysis Reveals Estrogen-Mediated RUNX2PDLIM3microRNA Crosstalk via ERG Signaling: Implications for Bone and Tissue Regeneration

The paper identifies an estrogen-mediated regulatory cascade involving PDLIM3, miR-9, miR-10, miR-6769b, and RUNX2 through ER/{beta} signaling, with implications for bone and tissue regeneration.

Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells.

This study shows Myosin VI regulates estrogen receptor activity and gene expression in breast cancer, with MVI inhibition enhancing hormone therapy effectiveness.

Mineralocorticoid and glucocorticoid receptor interaction drives TGFB1-induced triple-negative breast cancer progression to metastasis

This study shows that mineralocorticoid receptor (MR) and phosphorylated glucocorticoid receptor (p-GR) interaction promotes triple-negative breast cancer (TNBC) metastasis through migratory, stemness, and fibrotic mechanisms.

Methylation mimic mutations of progesterone receptor AF1 impair gene-specific regulation through stabilized chromatin interactions

This study shows that methylation mimic mutations in PR AF1 alter gene-specific regulation by affecting chromatin interactions and coregulator binding in breast cancer cells.

Estrogen Signaling During Abrupt Involution Leads to Long-Term Metabolic Dysfunction Similar to Estrogen Receptor Negative Breast Cancer

This study compares abrupt and gradual involution in mouse mammary glands, finding that abrupt involution leads to metabolic dysfunction resembling estrogen receptor negative breast cancer.

Comparative cistromic analysis reveals a shift in tamoxifen-associated endometrial tumor ERα binding toward sites less frequently shared by progesterone receptors

The paper compares ERα cistromes in endometrial tumors from tamoxifen users and non-users to ERα and PR cistromes in Ishikawa cells, finding shifts in ERα binding patterns associated with tamoxifen exposure.

Does sex matter in neurons response to hypoxic stress?

This study examines sex differences in neuronal response to hypoxia, finding that estrogen modulates network activity but does not provide long-term neuroprotection.

The multimerization pathway of the glucocorticoid receptor

The paper presents a new crystal structure of agonist-bound GR-LBD and proposes a model for GR multimerization, reconciling structural and functional data on glucocorticoid resistance.

Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface

This study shows mitoxantrone inhibits ERα by binding at the DBD-LBD interface, causing conformational changes and degradation, and effectively targets ER mutations resistant to current therapies.

Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells

This study identifies GRHL2 as a co-regulator of PR in breast cancer cells, showing their interaction and shared regulation of gene enhancers through chromatin looping.

Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape

This study investigates ESR1 and estrogen-driven transcription in human endometrial stromal cells using transcriptome, cistrome, and chromatin landscape data to identify gene regulation and its implications in decidualization and endometrial cancer.

Estrogen Receptor Enhancers Sensitive to Low Doses of Hormone Specify Distinct Molecular and Biological Outcomes

The paper examines the molecular effects of varying estradiol doses on estrogen receptor enhancers in breast cancer cells, finding distinct biological outcomes at low versus high doses.

Distinct 2-phenyl-imidazo pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor

The paper identifies X15695 as an AHR ligand that promotes ER degradation and inhibits ER+ breast cancer cell proliferation more effectively than fulvestrant.

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.