Alzheimer's disease research and treatments

Detection of a Unique Unfolded p53 Conformation (U-p53AZ) in Tissue of Alzheimers Disease Patients

The paper detects an unfolded p53 conformation (U-p53AZ) in Alzheimer's disease brain samples, showing colocalization with pTau in neurofibrillary tangles.

The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

This paper identifies Kallistatin's role in linking metabolic syndromes to cognitive decline by promoting amyloid-β plaques and tau hyperphosphorylation through Notch1 and GSK-3β pathways, and suggests fenofibrate as a potential treatment.

Upregulating ANKHD1 in PS19 mice reduces Tau phosphorylation and mitigates Tau-toxicity-induced cognitive deficits

This study shows that increasing ANKHD1 in PS19 mice reduces Tau phosphorylation and cognitive deficits by enhancing autophagy.

Modulation of Saccharomyces cerevisiae Stm1_N1-113 and human AB42 amyloid fibril morphology by 3,3'-(acridine-4,5-diylbis(methylene))bis(1-(carboxymethyl)-1H-benzimidazolium) dibromide

This paper investigates how Ac-BIM-acid affects amyloid fibril morphology of Stm1_N1-113 and Aβ42 using AFM and NMR, showing structural modulation at different concentrations.

Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.

The paper identifies amyloid fibril structures of CHCHD10 and links them to neurodegeneration, showing sequence differences between CHCHD10 and CHCHD2 allow co-aggregation.

Human tau compromises neuronal structural integrity in C. elegans promoted by age, stress and phosphorylation

This study shows human tau disrupts neuronal structure in C. elegans, with effects worsened by age, stress, and phosphorylation.

Amyloid-beta pathology increases synaptic engulfment by glia in feline cognitive dysfunction syndrome: A naturally occurring model of Alzheimer's disease

This study examines amyloid-beta pathology in feline cognitive dysfunction syndrome, finding increased synaptic engulfment by glia in aged and affected cats, mirroring Alzheimer's disease mechanisms.

Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation

This study shows that Ms4a4a deficiency reduces amyloid beta pathology in mice by enhancing Aβ clearance, supported by increased MMP-9 production in microglia and human CSF data.

Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

This study shows that 14-3-3ζ binding to phosphorylated Tau reduces its association with microtubules and inhibits aggregation and condensation.

Ndufs4 knockout induces transcriptomic signatures of Alzheimer's Diseases that are partially reversed by mitochondrial complex I inhibitor

This study shows that reducing mitochondrial complex I activity in mice induces AD-like transcriptomic changes, which are partially reversed by a complex I inhibitor.

Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner

This study shows that non-mutated human tau causes neurodegeneration in a microglia-dependent manner in a mouse model of Alzheimer's disease.

The microbiome shapes immunity in a sex-specific manner in mouse models of Alzheimer's disease

This study shows that the microbiome influences immune responses and cognitive deficits in sex-specific ways in mouse models of Alzheimer's disease.

Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing

The paper investigates the role of tau in VTA dopamine neuron dysfunction in Alzheimer's disease models, finding that tau induces hyperexcitability but impairs burst firing.

The Alzheimer's-Associated SORL1 p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility

This study identifies CD45 as a sialic acid-dependent binding partner of CD33, showing that their interaction contributes to Alzheimer's disease susceptibility through impaired microglial function.

A Human Neuron Alzheimer's Disease Model Reveals Barriers to Senolytic Translatability

The paper evaluates senolytic therapies in a human neuron AD model, finding Navitoclax's neurotoxicity and NK92's preferential targeting of senescent-like cells.

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

This study investigates how tau pathology affects metabolism and excitatory activity in mouse models, finding that it preserves glucose tolerance and shifts metabolic flux toward glutamate synthesis.

Polyserine-tau interactions modulate tau fibrilization

This study shows polyserine domains self-assemble and interact with tau to form sites of aggregation, accelerating tau fibrilization in vitro.

μ-Opioid Endomorphins and DDP-IV Inhibitor SitagliptinEnhance Amyloid-Beta Clearance and Memory in anAlzheimer's Cell Model

This study shows that endomorphins and sitagliptin improve amyloid-beta clearance and memory in an Alzheimer's cell model by reducing oxidative stress and Aβ42 aggregation.

The Alzheimer's therapeutic Lecanemab induces an amyloid-clearing program in microglia

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila

This study identifies nervous system requirements for Alzheimer's disease risk genes in Drosophila by analyzing gene function and neurodegeneration.

Platelets from early-stage Alzheimer patients show enhanced amyloid binding, an elevated open canalicular system and sex-specific differences in their activation profile

The paper shows that platelets from early-stage Alzheimer's patients bind more amyloid-beta, have altered morphology, and show sex-specific activation differences, suggesting potential as biomarkers for AD.

New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease

This study shows that HSD10 overexpression causes cytotoxicity linked to mitochondrial damage, and this effect is worsened by Aβ-rich environments, with inhibitors showing potential therapeutic benefit.

A Cooperative Model for Symmetric Ligand Binding to Protein Fibrils

The paper develops a cooperative binding model for ligands to protein fibrils, relating measured EC50 and IC50 values to intrinsic affinity and cooperativity.

N-Amino Peptide-Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

This study develops N-Amino Peptide-Graphene Quantum Dot loaded small extracellular vesicles to target tauopathies, showing improved specificity and efficacy in inhibiting tau aggregation and transmission.

Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer's Disease spectrum

The paper quantifies post-translational modifications of Aβ in brain tissue to distinguish amyloidosis stages in Alzheimer's Disease and related conditions.

Personalised Regional Modelling Predicts Tau Progression in the Human Brain

The paper develops a mechanistic model of tau protein dynamics using PET data to predict regional tau accumulation and disease progression stages in Alzheimer's patients.

Molecular and structural remodeling of stress granules in slowly and rapidly progressive Alzheimer's disease

This study characterizes stress granule structural and molecular changes in Alzheimer's disease subtypes using multi-omics approaches, revealing distinct features in rapidly progressive AD.

Anti-amyloid antibody effects on Aβ-42 protein aggregates profiled using nanospectroscopy

This study uses nanospectroscopy to analyze how anti-amyloid antibodies affect Aβ-42 protein aggregates, finding differences in oligomer reduction and fibril formation between aducanumab and lecanemab.