Diabetes and associated disorders

Common Genetic Variants Modify Disease Risk and Clinical Presentation in Monogenic Diabetes

The paper shows that common genetic variants influence disease risk and severity in monogenic diabetes, modifying clinical outcomes in individuals with pathogenic variants.

Curing autoimmune diabetes with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning

This study demonstrates that non-myeloablative conditioning with anti-CD117 antibodies and HCT can induce durable mixed chimerism and cure autoimmune diabetes in NOD mice.

Coxsackievirus B infection invokes unique cell-type specific responses in primary human pancreatic islets

This study investigates how Coxsackievirus B (CVB) infection affects different cell types in human pancreatic islets using single-cell RNA sequencing, revealing cell-specific transcriptional and functional responses.

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

Genetic association of T1D stratified by HLA DR3 and DR4 status reveals heterogeneity in pathways of progression to T1D

This study performs a genome-wide association study of T1D stratified by HLA DR3 and DR4 status, revealing genetic and biological heterogeneity in T1D progression.

Enabling reproducible type 1 diabetes polygenic risk scoring for clinical and translational applications

This paper develops a pipeline for translating type 1 diabetes polygenic risk scores into clinical use, showing they can distinguish type 1 from type 2 diabetes and identify high-risk individuals.

Elevations in plasma proinsulin predict the development of diabetes in NOD mice

This study shows that elevated plasma proinsulin and PI:C ratios predict diabetes onset in NOD mice and correlate with reduced beta cell Pc1/3 expression.

Inhibition of formate production blocks CD8+ T-cell responses and delays disease onset in a mouse model of type 1 diabetes

This study shows that inhibiting formate production in CD8+ T cells delays type 1 diabetes onset in mice by reducing their activation and effector function.

Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.

Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development

This study identifies aberrant immune regulation and stem-like CD8+ T cells in pancreatic lymph nodes during type 1 diabetes development using mass cytometry and single-cell RNA sequencing.

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

The paper analyzes immune cell changes in human pancreas-draining lymphatic tissues before and after T1D onset, identifying proinflammatory patterns and genetic risk correlations.

A novel bioinformatics approach reveals key transcription factors regulating type 1 diabetes-associated transcriptomes

This paper develops a bioinformatics pipeline to identify key transcription factors regulating type 1 diabetes transcriptomes, revealing novel molecular drivers and therapeutic targets.

NEUROD1 and PDX1 are low penetrance causes of MODY while rare variants in APPL1 and WFS1 are not associated with MODY

The paper assesses the genetic evidence for NEUROD1, PDX1, APPL1, and WFS1 in MODY, finding that only NEUROD1 and PDX1 variants are enriched, while APPL1 and WFS1 are not.

Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Reverses Type 1 Diabetes via Promoting Treg Function and CD8+ T cell exhaustion

This study shows that AAT-overexpressing MSCs reverse T1D in NOD mice by enhancing Treg function and inducing CD8+ T cell exhaustion.

GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

BASTA, a simple whole blood assay for measuring beta-cell antigen specific CD4+ T-cell responses in type 1 diabetes

Islet-antigen reactive B cells display a unique phenotype and BCR repertoire in autoantibody positive and recent-onset type 1 diabetes patients

The paper identifies unique phenotypic and BCR repertoire features of pancreatic islet antigen-reactive B cells in prediabetic and recent-onset type 1 diabetes individuals compared to non-diabetic donors.

Redirecting TCR specificity in regulatory T cells toward class I HLA antigens mediates tissue-specific homing

The paper redirects TCR specificity in regulatory T cells toward class I HLA antigens to enhance tissue-specific homing in Type 1 Diabetes.

Reduced function of the adaptor SH2B3 promotes T1D via altered γc cytokine-regulated, T cell intrinsic immune tolerance

This study identifies SH2B3 as a critical regulator of T cell tolerance in T1D, showing that its deficiency enhances cytokine signaling and promotes islet destruction.

Imaging mass cytometry reveals early β-cell dysfunction and changes in immune signatures during type 1 diabetes progression in human pancreata

The paper uses imaging mass cytometry to analyze human pancreatic samples and identifies early β-cell dysfunction and immune changes in type 1 diabetes progression.

Linking molecular pathways and islet cell dysfunction in human type 1 diabetes

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice

This study shows that inhibiting NAMPT reduces inflammation and beta-cell damage in T1D by blocking cytokine-mediated immune responses in mice.

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores

This study estimates that ~6% of insulin-treated diabetic individuals with ambiguous features in British Pakistanis and Bangladeshis have T1D, highlighting the need for autoantibody and C-peptide testing.

Integrative proteogenomic analyses provide novel interpretations of type 1 diabetes risk loci through circulating proteins

The paper uses proteogenomic data to identify circulating proteins associated with type 1 diabetes risk and explores their tissue-specific expression.

Sex-Specific Cytokine, Chemokine, and Growth Factor Signatures in T1D Patients and Progressors

This study identifies sex-specific cytokine, chemokine, and growth factor differences in T1D patients and progressors, highlighting potential implications for personalized treatment.

Immune mechanisms of type 1 diabetes revealed by single-cell transcriptomics, bulk transcriptomics, and experimental validation

This study identifies key genes and monocytes in T1D pathogenesis using scRNA-seq, bulk RNA-seq, and experimental validation, showing high diagnostic model efficiency.

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

This study shows that blocking CD226 reduces diabetes in NOD mice by enhancing Treg function and reducing effector T cell activity.

Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes

This study identifies genetic risk factors for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes and develops a new risk score for better classification.

Longitudinal blood microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes

The paper uses frequent blood microsampling and proteome analysis in a mouse model to detect early biomarkers of type 1 diabetes, enabling timely intervention.

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice

This study shows that inhibiting 12-LOX with VLX-1005 delays autoimmune diabetes onset in human gene replacement mice by altering inflammatory pathways and immune cell infiltration.