Diabetes and associated disorders

Re-analysis of Transcriptomic and Proteomic Data Using Multi-Omics Approaches Identifies Biomarkers of Diabetes-Associated Complications in an INS Mutant Pig Model

The paper re-analyzes transcriptomic and proteomic data from a diabetes model to identify a novel biomarker associated with immune dysfunction and delayed wound healing.

Performance of a Type 1 Diabetes Genetic Risk Score in a Multi-centric Study from India and its Implications in Clinical Practice

This study evaluates the performance of a type 1 diabetes genetic risk score in Indian populations, finding it effective for classification but with variations based on autoantibody status and age at onset.

Interference with MHC class I epitope trimming provides paradoxical protection from autoimmune diabetes

The paper shows that reducing MHC class I epitope trimming in NOD mice delays diabetes by altering T cell responses and epitope presentation.

Calorie Restriction Up-regulates Islet PD-L1 Signaling and Decreases the Risk of Auto-immune Diabetes Onset in NOD Mice.

This study shows calorie restriction delays type 1 diabetes onset in NOD mice by enhancing glucose homeostasis and promoting a pro-tolerogenic islet microenvironment through increased PD-L1 expression.

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood

The paper identifies TCR subsequence motifs associated with type 1 diabetes using deep learning and shows their enrichment in T1D individuals based on HLA risk alleles.

Glucose-Responsive CD20+ Cytotoxic T Cells: A Novel Pro-inflammatory Mediator in the Immunopathogenesis of Type 2 Diabetes

This study identifies CD20+ cytotoxic T cells as glucose-responsive, hyperfunctional cells in T2D that correlate with metabolic parameters and may contribute to inflammation.

RIPK1 regulates beta-cell fate via actions on gene expression and kinase signaling in a mouse model of beta-cell self-reactivity

This study shows RIPK1 promotes beta-cell death in autoimmune diabetes by affecting gene expression and kinase signaling, suggesting it as a therapeutic target.

Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression

This study integrates histopathological data from the human pancreas across T1D stages to identify novel histopathological correlates, particularly in the prodromal stage.

Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B

The paper identifies tri-SNP haplotypes in HLA-DRA associated with type 1 diabetes and celiac disease, and links them to differences in complement system genes C4A and C4B.

Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes

Loss of Exocytosis Protein DOC2B is an Early Event in Type 1 Diabetes Development

The paper identifies DOC2B decline as an early biomarker of presymptomatic type 1 diabetes progression, preceding traditional markers like C-peptide and HbA1c.

Protective IFIH1 variant reduces immune-mediated islet stress and dysfunction in a type 1 diabetes genetic background

This study shows that the IFIH1 E627* variant protects human pancreatic islets from stress-induced dysfunction by reducing immune responses and apoptosis.

Islet amyloid disrupts MHC Class II antigen presentation and protects NOD mice from autoimmune diabetes.

This study shows that islet amyloid disrupts MHC Class II antigen presentation in islet macrophages, protecting NOD mice from autoimmune diabetes by reducing immune cell infiltration and antigen-specific T cell activation.

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes

This study identifies UTX's role in regulating progenitor CD8+ T cell fate in T1D by interacting with TCF1 and STAT3, showing its importance in autoimmune diabetes progression.

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

The paper uses 3D imaging to analyze pancreatic islets in healthy and type 1 diabetes (T1D) individuals, finding that islet size and composition influence their loss in T1D.

An imbalance of naive and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsets

The paper identifies reduced effector and cytotoxic T-cell gene expression in early type 1 diabetes across multiple T-cell subsets using single-cell transcriptomics and flow cytometry.

Long non-coding RNAs as a novel source of beta cell autoantigens in type 1 diabetes

This study identifies lncRNA-derived peptides that act as autoantigens in type 1 diabetes by activating CD4+ T cells through HLA-II restricted epitopes.

DRB1 Subtyping Reveals Divergent Risk and Protection for Type 1 Diabetes in Middle Eastern Populations

The paper develops a machine learning-based T1D risk model tailored to Middle Eastern populations, showing improved performance over existing models in this region.

A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes

The paper identifies a microenvironment-driven neoantigen, C19S, in type 1 diabetes that activates persistent memory T cells through HLA-DQ8 recognition.

Transcriptomic module fingerprint reveals heterogeneity of whole blood transcriptome in type 1 diabetic patients

The paper develops a gene signature to distinguish type 1 diabetic patients from healthy donors using whole blood transcriptomic data, finding that combining multiple analytical methods improves classification accuracy.

Antigen presenting cells play a critical role in determining response to regulatory T cell therapy in type 1 diabetes

This study develops a mathematical model to show that antigen-presenting cell dynamics significantly influence the effectiveness of regulatory T cell therapy in type 1 diabetes.

Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

Proinflammatory circulating extracellular vesicles from type 1 diabetes patients contribute to beta cell cytotoxicity and disease pathogenicity

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

This study shows stressed β-cells increase MMP-3, leading to loss of peri-islet ECM in T1D, suggesting MMP-3 inhibition could prevent islet death.

Islet-intrinsic sex differences in inflammatory signaling contribute to autoimmune diabetes susceptibility

This study identifies sex-specific islet responses to inflammation and shows that estrogen reduces inflammatory signaling and promotes immune tolerance in beta cells, contributing to sex differences in type 1 diabetes susceptibility.

The G protein-coupled receptor GPR31 governs inflammatory signaling in the pancreatic islet microenvironment

This study identifies GPR31 as a key inflammatory regulator in pancreatic islets, showing its role in β-cell stress and macrophage activation in type 1 diabetes.

HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry

This paper develops ancestry-specific and combined HLA-focused genetic risk scores for type 1 diabetes and evaluates their performance across diverse populations.

Whole tissue spatial cellular analysis reveals increased macrophage infiltration in pancreata of autoantibody positive donors and patients with type 1 diabetes

The paper quantifies macrophage infiltration in pancreatic tissue of type 1 diabetes donors and finds increased infiltration and HLA-II expression in islet regions, suggesting a role in disease progression.

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

This study uses single-cell multiomics and spatial transcriptomics to identify gene regulatory programs in pancreatic cell types that drive type 1 diabetes progression.