T-cell and B-cell Immunology

EBF1 regulates the blood-thymus barrier and ETP influx through Claudin-5 in thymic endothelial cells

This study shows EBF1 regulates the blood-thymus barrier by modulating Claudin-5 expression in thymic endothelial cells, affecting early thymic progenitor influx.

Differential composition of lymphocyte subpopulations and activation between the hypertensive Bph/2 and normotensive Bpn/3 mouse strains

This study compares immune cell composition and activation between hypertensive Bph/2 and normotensive Bpn/3 mice, finding differences in B and T cell subpopulations and reduced cytokine responses in Bph/2 mice.

Reduced B cell activation in Germinal center reaction of the mouse model of Li-Fraumeni syndrome

This study shows that p53 mutations in Li-Fraumeni syndrome mice reduce B cell activation during germinal center reactions without affecting the ratio of activated B cells in dark and light zones.

TCF1lo CD8 T cells proliferate and persist autonomously in tumors

This study shows that TCF1lo CD8 T cells in tumors can proliferate and persist autonomously, challenging the idea that only TCF1hi cells self-renew.

MAPKAP Kinase 2 Orchestrates Memory T Cell Inflation in Cytomegalovirus Infection

This study shows that MK2 regulates CD8 T cell inflation during CMV infection by affecting their expansion and differentiation.

Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel

The paper develops a 64-plex single-HLA reporter cell panel and analysis tool to identify and characterize allogeneic HLA-specific B cells in sensitized individuals.

cloneXplorer: A high-throughput clone discovery platform based on conical microwell arrays

The paper introduces cloneXplorer, a platform for generating antigen-specific T cell clones from peripheral blood using conical microwell arrays, and demonstrates its ability to identify and isolate functionally defined T cells.

Commensal-derived Trehalose Monocorynomycolate Triggers γδ T Cell-driven Protective Ocular Barrier Immunity

This paper identifies trehalose monocorynomycolate (TMCM) from C. mast as a stimulator of IL-17-producing γδ T cells at the ocular surface, which protects against corneal infection.

Embryonic lympho-epithelial cell interactions play an essential role in the establishment of adult T cell tolerance

This study shows that early thymic seeding progenitors are crucial for thymic epithelial maturation and regulatory T cell development, preventing age-related autoimmunity.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

Glucose availability tunes latent CD8+ T cell expansion potential through a mitogen-independent, mTOR-dependent regulatory switch

This study shows glucose availability independently regulates CD8+ T cell expansion potential through mTOR-dependent mechanisms, distinct from mitogenic signals.

Transcriptomic profiling of human γδ T cells reveals non-linear immune aging characterized by childhood transitions and relative stability in adulthood

This study maps the aging trajectories of human γδ T cells using single-cell transcriptomics, revealing non-linear aging with distinct childhood transitions and stability in adulthood.

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

Neonatal liver niches program T cell tolerance

The paper identifies a neonatal liver program that expands regulatory T cells while limiting conventional T cell activation, influencing susceptibility to viral infections and protection against liver disease.

Polymer of methyl malonic acid suppress inflammation by downregulating IL-2 through ROS overproduction

This paper develops a polymer, 1,6 MMA, that suppresses inflammation by reducing IL-2 and increasing mitochondrial ROS in T cells, showing therapeutic potential in collagen-induced arthritis.

IL-12R signaling promotes type 1 regulatory T cell specialization by sustaining T-bet

This study shows IL-12R signaling sustains T-bet in Treg cells, promoting type 1 specialization and enhancing suppressive function against Th1 responses.

Single-cell analysis reveals multi-faceted features of B cell development together with age-associated B cell subpopulations

This study uses single-cell transcriptomics and BCR sequencing to analyze B cell development and identifies age-associated subpopulations and key regulatory dynamics.

A capture assay to analyse immunoglobulin secretion at the single-cell level

This paper introduces a capture assay to measure single-cell antibody secretion in B cells during plasma cell differentiation.

Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse

This study identifies BTN2A2 as a CD45RO ligand that enhances CD45 phosphatase activity, promoting Treg expansion and reducing Th17 cells, thereby ameliorating autoimmunity in mice and humans.

A Fundamental Relationship between TCR Diversity, Repertoire Size and Systemic Clonal Expansion: Insights from 30,000 TCRβ Repertoires

The paper analyzes TCRβ repertoires from 30,000 individuals to show that TCR diversity is primarily determined by repertoire size and the frequency of the 1,000 most abundant clones, explaining 96% of variance in diversity.

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4+ T cells in humans.

This study identifies a distinct stem-cell memory subset in CD4+ T cells that is pre-committed to a cytolytic program, showing similarities to CD8-CTLs and demonstrating the potential for generating long-lived cytotoxic CD4+ T cells.

T-bet expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape

This study identifies a dominant population of IL-10-producing, T-bet-expressing CD4+ Tr1 cells in the small intestine that are shaped by dietary antigens rather than the microbiota.

Regulatory T cells clonally expand and contribute to stromal cell function in fibrotic response to synthetic implants

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

Single-cell characterization and machine learning-based classification reveal the transcriptional identity and antigen-experienced features of peripheral CD4+CD8+ double-positive T cells

The paper identifies and classifies rare peripheral CD4+CD8+ double-positive T cells using single-cell RNA sequencing and machine learning, revealing their antigen-experienced features and cytotoxic potential.

Metabolomic Profiling Reveals Potential of Fatty Acids as Regulators of Stem-like Exhausted CD8 T Cells During Chronic Viral Infection

This study identifies fatty acids as regulators of stem-like exhausted CD8 T cells during chronic viral infection, showing their impact on mitochondrial fitness and viral control.

The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T cell generation

This study shows NR4A3 is not required for generating CD8+ resident memory T cells in epithelial or non-epithelial sites, unlike NR4A1 and NR4A2.

Fezf2 regulates differentiation of Aire-expressing and post-Aire mimetic epithelial populations maintaining thymic homeostasis

This study shows Fezf2 regulates mTEC lineage commitment and homeostasis, with transcriptional repression playing a key role in maintaining thymic epithelial populations.

FAM83H regulates postnatal T cell development through thymic stroma organization

This study shows that FAM83H is essential for thymic stroma organization and T cell development, as its deficiency leads to impaired thymic architecture and reduced T cell production.

IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death

The paper investigates how glucocorticoids affect B cell survival by altering IgD and IgM expression, showing that IgDlow B cells are more resistant to GC-induced death.