T-cell and B-cell Immunology

Tissue-distinct Features of Follicular Cytotoxic CD8+ T Cells in Trypanosoma cruzi infection

This study identifies tissue-specific features of T follicular cytotoxic cells in T. cruzi infection, showing distinct metabolic and functional states in spleen and lymph nodes.

CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic state and high tolerogenic potential

This study shows neonatal human naive CD4+ T cells have higher CD38 expression, linking it to glycolytic metabolism and tolerogenic function compared to adult cells.

Treg-derived IκBζ promotes their conversion into Th2-like effectors and drives type 2 inflammation via BATF

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

Antibody-mediated feedback modulates interclonal competition in the germinal center

The paper investigates how antibodies from an ongoing immune response affect interclonal competition in germinal centers, finding that antibody feedback reduces clones recognizing the same epitopes as circulating antibodies.

The magnitude of the secondary B cell response is primarily defined by antibody feedback inhibition rather than the number of memory B cells present

The study shows that the secondary B cell response magnitude is driven by antibody feedback inhibition, not the number of memory B cells before vaccination.

Identification of a Highly Functional Effector CD8+ T Cell Program After Transplantation in Mice and Humans

This study identifies a functional effector CD8+ T cell program in mice and humans that persists into memory after antigen clearance, driven by CD43 1B11 expression.

Immediate transcriptional changes initiated by direct cell-cell contact between cytotoxic T cells and cancer cells

The paper investigates immediate transcriptional changes in T cells upon direct contact with cancer cells using single-cell transcriptomics and identifies distinct T cell subsets associated with reduced TCR diversity.

Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation.

The paper identifies distinct plasma cell differentiation routes in humans using single-cell multiomic profiling and functional validation, showing CD30+ intermediates and their regulation by MEF2C and BAFF/APRIL.

Memory T cell rapid recall is driven by memory-specific AP-1 recruitment determined by epigenome and co-factor interactions

The paper identifies memory-specific AP-1 recruitment in T cells, driven by epigenetic changes and co-factor interactions, and links it to disease risk variants.

TCR signal strength determines Treg instability and discrimination of self versus non-self antigens

The paper shows that strong TCR signals from foreign antigens destabilize Tregs, converting them into effector-like cells, while self-antigens preserve stability, revealing a mechanism for balancing immunity and tolerance.

TCR Signal Strength and Eomes Coordinate CD8⁺ T Cell Fate and Antitumor Immunity in Hepatocellular Carcinoma

This study shows that TCR signal strength and Eomes determine CD8+ T cell fate in HCC, with high-affinity signals promoting antitumor immunity and Eomes driving exhaustion.

Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood

This study examines age-related differences in T follicular helper cell function and their impact on antibody responses across human development.

CD28 Co-stimulation Is Organized by Signaling Condensates and Counteracted by PD-1

This study shows CD28 co-stimulation forms signaling condensates with Lck, which PD-1 modulates by binding and disrupting these structures, leading to engineered CAR T cells with improved antitumor activity.

Overmaturation as a major trajectory of naive CD4 T cell aging

This study identifies transcriptional overmaturation as a key trajectory in naive CD4 T cell aging, showing aging-related changes mirror normal maturation processes.

Lymph node resident memory T cells retain effector capabilities by evading lung resident memory dysfunction.

This study identifies lymph node resident memory T cells (LNRM) as a distinct subset with unique effector capabilities compared to lung resident memory T cells and central memory T cells.

A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance.

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

Downregulation of Satb1 is required to prevent autoimmunity by maintaining Tfh homeostasis

This study shows that Satb1 downregulation prevents autoimmunity by maintaining Tfh cell homeostasis and preventing excessive GC formation and auto-antibody secretion.

Glycosylated GM-CSF expands B-1b cells and B-1b plasma cells and programs them for immunosuppression

This study shows glycosylated GM-CSF expands immunosuppressive B-1b plasma cells and promotes regulatory functions, while non-glycosylated GM-CSF drives pro-inflammatory responses.

Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function

The paper compares T cell landscapes in mice with normalized microbial exposure (NME) and specific pathogen-free (SPF) conditions, finding increased effector memory CD8+ T cells in NME mice.

MicroRNA-17~92 drives metabolic programming of virus-specific effector CD4 and CD8 T cell responses

This study shows miR-17~92 promotes T cell proliferation and effector differentiation by regulating metabolic pathways like glycolysis and mTOR activation in viral antigen-specific CD4 and CD8 T cells.

Suppression of CD4 T cells by Tregs dictates metabolic remodeling of CD8 T cells during effector to memory transition

This study identifies Treg-mediated suppression of CD4 T cells and inflammatory myeloid cells as critical for metabolic remodeling of CD8 T cells during the effector-to-memory transition.

Tissues Guide Dependence of Treg on the Transferrin Receptor

This study shows that loss of the transferrin receptor (CD71) in Treg cells leads to tissue-specific inflammation and autoimmunity, highlighting the role of CD71-iron metabolism in Treg stability and function.

An early mTOR-dependent window during human T cell activation programs T cell state

This study identifies an early mTOR-dependent window during human T cell activation that programs cytotoxic fate or memory-like state, with transient inhibition promoting memory while preserving effector functions.

IL-21 selectively augments cytotoxic potential of antigen-activated MAIT cells

This study shows IL-21 enhances cytotoxicity of activated MAIT cells by increasing GrzB and perforin expression without significantly affecting cytokine production.

Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity

A CRISPR screen identifies V-type ATPases, PI4K, DDX3X, and MYD88 as key regulators of secretory capacity and lifespan in long-lived plasma cells.

Dynamics of memory B cells and plasmablasts in healthy individuals

The paper infers memory B cell and plasmablast dynamics using statistical methods, finding slow clone degradation and high plasmablast differentiation rates.

The innate cytokine IL-18 inhibits CNS autoimmunity through preferential activation of protective CD8 T-cells

This study shows that excess IL-18 protects against CNS autoimmunity by activating CD8 T-cells to suppress CD4 T-cells involved in autoimmune encephalomyelitis.

Scalable TCR synthesis and screening enables antigen reactivity mapping in vitiligo

The paper introduces a scalable TCR synthesis and screening method, TCRAFT, to map antigen reactivity in vitiligo and pancreatic ductal adenocarcinoma.

Differential proteomic and metabolic remodelling of CD4⁺ and CD8⁺ T cells in mesenteric lymph nodes during colitis-associated colorectal cancer

The paper uses mass spectrometry to analyze proteomic and metabolic changes in CD4⁺ and CD8⁺ T cells during colitis-associated colorectal cancer in mice, revealing distinct adaptations between the two cell types.