T-cell and B-cell Immunology

The T-cell receptor repertoire of wild mice

This study examines the T-cell receptor repertoire in wild mice, finding that repertoire diversity varies with age and sex, while richness remains stable.

Epigenetic mechanisms regulating CD8+ T cell senescence in aging humans

This study identifies epigenetic regulators of CD8+ T cell senescence in aging humans using multiomic profiling and shows their relevance to disease progression.

Impact of Absent in Melanoma 2 (AIM2) on Antigen-Specific CD4+ T cell Activation and Homeostasis.

This study investigates AIM2's role in CD4+ T cell activation and homeostasis, finding it promotes IL-2 production in vitro but not essential for in vivo functions like tumor control.

Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin

This study shows that antigen encounter in the epidermis enhances TRM persistence and proliferation through TGF{beta} signaling and TGF{beta}RIII expression.

Altered B Cell Metabolic Pathways Characterize Type 1 Diabetes Progression

This study investigates how altered B cell metabolic pathways, particularly HIF-1 signaling, contribute to Type 1 Diabetes progression by shifting B cell differentiation toward inflammatory subsets.

Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

Intravital imaging the formation and resolution of MHC class II-positive T cell activation niches

The paper develops two fluorescent reporter mice to track MHC class II and CD8-positive T cells in vivo, enabling long-term imaging of immune response dynamics.

Imprinted antibody lineages can persist for half a century and dominate cross-neutralizing recall responses to poliovirus

This study shows that imprinted antibody lineages can persist for over 50 years and dominate cross-neutralizing recall responses to poliovirus.

PI3Kdelta promotes T cell effector differentiation and plasticity during chronic infection

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

Immune-mediated Engagement of T Regulatory Cells with Tumor Cells Results in Trogocytosis and Tumor Cell Killing.

The paper shows CD4 T regulatory cells can kill tumor cells through trogocytosis after immunocytokine treatment in a melanoma model.

TCR repertoire analysis quantifies effect of irradiation to homeostasis of iNKT cell development in the thymus of mice

The paper quantifies how irradiation affects iNKT cell development in the thymus of mice by analyzing TCR repertoire changes and recovery dynamics.

Phenotypic Approaches to T Cell Activation: A Comparative Mathematical Modeling Study

This study compares nine mathematical models of T cell activation to evaluate their ability to replicate key features like specificity, sensitivity, and antigen discrimination.

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

The paper examines T-bet expression stability in virus-specific Th1 cells during chronic infection, finding that quantitative differences persist and some cells retain Tfh-like features.

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells

This study identifies BATF3 as a critical regulator of innate-like γδ T cell homeostasis, function, and tissue distribution, revealing its role in survival, IL-17 production, and immune responses.

4-1BB expression and signaling regulates MAIT cell activation and effector functions

This study shows that 4-1BB expression and signaling enhance MAIT cell activation and effector functions through TCR and cytokine signals.

Opposing Functions of Distinct Regulatory T Cell Subsets in Colorectal Cancer

The paper identifies two distinct regulatory T cell subsets in colorectal cancer with opposing roles in tumor growth and prognosis.

Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans

The paper identifies GNG4 as a marker for activated CD4 T follicular helper cells in human germinal centers using multimodal single-cell analysis.

Statistical modelling of CDR3 sequences provides robust quality control for TCR repertoire datasets

The paper quantifies how V and J gene usage affects CDR3 length and amino acid composition in TCR repertoires and provides a quality control framework for TCR sequencing data.

Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

Sparse, random sampling is sufficient for central tolerance

The paper shows that sparse, random sampling of self peptides in the thymus is sufficient for T cell tolerance to most peripheral self peptides, supported by experimental data and machine learning analysis.

Controlling TCR and CAR activation by targeting LCK recruitment with a first-in-class small-molecule inhibitor

This study identifies a small-molecule inhibitor that selectively disrupts LCK recruitment to CD3ε, reducing TCR activation while preserving other immune responses.

Divergent effects of a Treg selective IL-2 mutein on Influenza-specific T cell responses

This study examines how a Treg-selective IL-2 mutein affects influenza-specific T cell responses, showing opposing effects based on administration timing.

Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8+ T cells

This study identifies Noxa's role in metabolic reprogramming to glutamine dependence in CD8+ T cells, independent of its canonical apoptotic function, and suggests its potential as an immunotherapeutic target.

A Falsifiable Framework for Testing Neutralityin T-Cell Receptor Repertoire Databases

The paper introduces a falsifiable framework to test neutrality in TCR repertoire databases using a biologically calibrated null model, revealing public clonotype patterns inconsistent with neutral drift.

Tissue-specific tolerance mechanisms and lymph node co-drainage converge to shape T cell immunity in the upper digestive system and regulate pancreatic cancer progression

Access to germinal center IL-4 microniches drives tissue-divergence of IgE memoryresponses

The paper shows that IgE memory responses are confined to lymphoid organs through GC IL-4 microniches, which are critical for IgE production during allergen recall.

BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells

The paper identifies BCL6 and CD4+ T cell dependence in generating functional IgM+ memory B cells independent of germinal center formation.

Optimized In Vitro Expansion of Vδ1+ γδT Cells from Nonhuman Primate Peripheral Blood

This study optimizes in vitro expansion of Vδ1+ γδT cells from nonhuman primate PBMCs using CD3 or PHA stimulation with cytokines and phospho-vitamin C, achieving high-fold expansions.

In vivo sequential mutagenesis in germinal center B cells using a dual-recombinase approach: FOXO1 re-expression upon FOXO1 knockout rescues class switch recombination

The paper introduces a dual-recombinase system for sequential mutagenesis in germinal center B cells, enabling FOXO1 knockout and subsequent re-expression to study its effects on class switch recombination.