Alzheimer's disease research and treatments

The Christchurch point mutation in mouse APOE reduces Aβ-induced tau and α-synuclein pathologies

This study investigates the protective effects of the APOE CC mutation against Aβ, tau, and α-synuclein pathologies in mouse models of neurodegenerative diseases.

The Icelandic mutation APPA673T on amyloid-β plaque burden in the 5xFAD Alzheimer model

This study investigates the effect of the APPA673T mutation on amyloid-β plaque burden in 5xFAD mice, finding a significant reduction in plaque size but not in soluble Aβ levels.

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimers Disease

The paper identifies cell type-specific gene modules associated with Alzheimer's Disease traits using snRNASeq data from human brain tissues.

eIF2Bϵ phosphorylation activates integrated stress response-mediated protein translation and links stress signalling toamyloidogenesis in Alzheimer's disease

This study identifies a novel GSK-3β-eIF2Bε-BACE1 axis that links stress response dysregulation to amyloidogenesis in Alzheimer's disease, independent of canonical eIF2 phosphorylation.

Sex-dependent effects of maternal high-fat diet during lactation in adult THY-Tau22 mice offspring

This study shows that maternal high-fat diet during lactation accelerates tauopathy in THY-Tau22 mice, with sex-dependent effects where males are more affected earlier than females.

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein Tau

This study identifies Praja1 as an E3 ligase that ubiquitinates and degrades Tau, a key protein in tauopathies, and shows evolutionary conservation of this interaction.

AHA1 regulates Aβ production via modulation of APP expression and γ-secretase assembly

This study shows that AHA1 regulates Aβ production by modulating APP expression and γ-secretase assembly, suggesting it as a therapeutic target for Alzheimer's disease.

Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomes

This study shows that tau seeding in neurons occurs via transient endolysosomal perforations that remain confined within endolysosomes and require PIKfyve activity.

Integrating explainable AI with multiomics systems biology and EHR data mining for personalized drug repurposing in Alzheimer's disease

PRISM-ML integrates multi-omics and EHR data to identify drug repurposing opportunities in Alzheimer's disease by analyzing molecular heterogeneity and predicting therapeutic targets.

Proteomic Subtyping of Alzheimer's Disease CSF links Blood-Brain Barrier Dysfunction to Reduced levels of Tau and Synaptic Biomarkers

The paper identifies six CSF proteomic subtypes in Alzheimer's disease, linking BBB dysfunction to reduced tau and synaptic biomarkers, particularly in African Americans and men.

Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease

This study shows that deleting ADAP1/CentA1 in Alzheimer's disease mice reduces cognitive impairment and neuropathological features, with transcriptome analysis identifying Bid as a key mediator.

Exploring Proteomic Differences in PBMCs for Sex-Specific Insights into Alzheimer's Disease

The paper compares proteomic profiles of PBMCs from male and female Alzheimer's patients and controls to identify sex-specific differences in disease mechanisms.

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

The paper analyzes the transcriptomic landscape of the human locus coeruleus in relation to Alzheimer's disease risk factors and neuromelanin content using spatially-resolved transcriptomics.

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

The paper examines sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive performance using bulk transcriptomic data from 767 individuals.

Neuronal glycolytic reprogramming drives lethality via accelerated aging in a Drosophila model of tauopathy

This study shows that tau-induced glycolytic reprogramming in Drosophila neurons accelerates aging and causes lethality, indicating glycolysis drives rather than protects against tauopathy.

Dual Inhibitors Targeting G9a and GSK-3B: Translational Perspectives on Alzheimer's Disease Treatment

This paper introduces a dual inhibitor targeting G9a and GSK-3β for Alzheimer's disease, showing improved memory and synaptic function in a mouse model.

Tau catalyzes amyloid-β aggregation in a fold-dependent manner

This study shows tau proteins from Alzheimer's and CTE folds catalyze Aβ42 aggregation in a fold-specific manner, increasing toxicity and offering new therapeutic insights.

DNA Break Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model

This study shows that DNA damage-induced epigenetic changes in an Alzheimer's mouse model lead to cognitive deficits and altered amyloid pathology.

Thermal cycling stimulation via nasal inhalation attenuates Aβ25-35-induced cognitive deficits in C57BL/6 mice

This study investigates the effects of thermal cycling-stimulation via nasal inhalation on cognitive deficits in mice with Aβ25-35-induced Alzheimer's disease, finding improvements in cognitive performance and reduced Aβ accumulation.

Adolescent intermittent ethanol exacerbates Aβ with age in the dorsal hippocampus of female TgF344-AD rats.

This study shows that adolescent intermittent ethanol increases Aβ levels in the dorsal hippocampus of aged female TgF344-AD rats, suggesting early-life ethanol exposure exacerbates Aβ pathology with age.

Neuroprotective function of astrocyte p75NTR in Alzheimer's Disease through regulation of cholesterol metabolism

This study shows that astrocyte p75NTR regulates cholesterol metabolism, reducing Aβ burden and cognitive impairment in Alzheimer's Disease.

The human neuroblastoma SH-SY5Y cell line as a model to assess β-amyloid neurotoxicity: A systematic review and meta-analysis

This paper reviews and analyzes 359 studies on β-amyloid toxicity in SH-SY5Y cells, finding that toxicity depends on Aβ concentration, exposure time, and aggregation state, not cell differentiation.

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer disease and aging.

This study uses bulk RNA-seq to analyze transcriptional changes in the middle temporal gyrus across Alzheimer's disease and aging, identifying distinct gene expression patterns and pathways associated with each condition.

NPTX2-Centered Cognitive Resilience Mechanisms in the Context of AD Pathology

The paper identifies molecular programs coordinated with NPTX2 that distinguish cognitive resilience in AD pathology from non-pathological cognition and AD.

Modeling Alzheimer's Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets

The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.

Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling

This study shows that inhibiting the CGRP receptor reduces AD pathology by reprogramming lipid metabolism via the HDAC11/LXRβ/ABCA1 signaling pathway in both human and mouse models.

Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency

This study shows that tau filament seeding capacity depends on both core structure and phosphorylation in the fuzzy coat, with phospho-mimetic residues restoring activity in modified tau.

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunction

This study identifies lysosomal proteome changes caused by apoE4, linking them to lysosomal dysfunction and Alzheimer's disease pathology.

Chimpanzee and human ApoE isoforms differ in the stimulation of neurite differentiation consistent with structural predictions with relevance to brain development and aging

The paper shows chimpanzee ApoE isoforms increase neurite number but reduce neurite length compared to human ApoE isoforms, suggesting functional similarity to ApoE4.

Beyond the Genotype: A Multi-Omic Analysis of APOEe4's Role in Alzheimer's Disease

This paper investigates how APOEe4 influences molecular changes in Alzheimer's disease through proteomic, epigenetic, and genetic analyses of post-mortem brain samples, identifying key proteins and epigenetic markers associated with risk and resilience.