Wnt/β-catenin signaling in development and cancer

Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis.

The paper shows Rab8a-dependent vesicular trafficking transports Wnt8a along cytonemes in zebrafish embryos, affecting Wnt signaling and embryonic patterning.

Cytolethal distending toxin promotes epithelial-to-mesenchymal transition by modulating AKT-Dependent β-catenin Ser552 phosphorylation

This study shows that CDT induces β-catenin Ser552 phosphorylation via AKT, leading to EMT and cancer-related changes in epithelial cells.

Integrin beta 4 promotes colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin signaling pathway

This study identifies ITGB4 as a driver of colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin pathway.

Oncomimetic β-catenin activity onset, duration and region defines aberrant intestinal development

This study uses a chemical-optogenetic approach to control β-catenin activity in mouse small intestinal organoids, revealing persistent aberrant phenotypes and altered differentiation during homeostasis.

Wnt signaling regulates passive cell competition in the retina by inducing differential cell adhesion

The paper shows that Wnt signaling, through {beta}-catenin, regulates passive cell competition in the retina by inducing a cadherin switch that segregates cells into distinct compartments.

Junctional β-Catenin Stabilization Links Wnt Signaling and Force Generation

The paper measures β-catenin protein stability in vivo during development and finds stabilization at the leading edge during dorsal closure, linked to adhesion function and regulated by Dishevelled and JNK.

Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis

This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.

GATA transcription factors act as gatekeepers between the Wnt/β-catenin-mediated proliferation and differentiation in the intestinal epithelium

The paper shows GATA transcription factors modulate Wnt/β-catenin signaling to control cell identity in the intestinal epithelium by repressing secretory lineage genes in stem cells.

WNT-driven chromosomal instability as a biomarker for PORCN inhibition

This paper identifies a chromosomal instability (CIN) biomarker that predicts response to PORCN inhibitors in cancers, validated through in vitro models, cell lines, and patient data.

New three-dimensional preclinical models to understand and treat liver cancers activated for the β-catenin pathway

This paper develops 3D preclinical models of β-catenin-driven liver cancers using organoids and tumouroids from mouse models, showing they preserve tissue features and respond to WNTinib treatment.

Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC

The paper shows that Wnt signaling in mesenchymal TNBC cells increases inflammation and EMT-related gene expression, and identifies a 55-gene signature associated with these effects.

Nup358 Sustains Intestinal Epithelial Homeostasis by Preventing Dvl1 Condensate Formation to Restrain Wnt Signaling

This study shows Nup358 prevents Dvl1 condensate formation, which restrains Wnt signaling and maintains intestinal epithelial homeostasis by preserving TA progenitor cells.

A Wnt-responsive fibrocartilage progenitor system coordinates postnatal mandibular condylar cartilage growth

The paper identifies a Wnt-responsive fibrocartilage progenitor system that coordinates postnatal mandibular condylar cartilage growth through Foxm1-dependent proliferation and suppression of TGF-β-driven chondrogenic differentiation.

Reassessment of RNF43 Function Reveals No Impact on Endogenous EGFR or BRAF Protein Stability

This study investigates whether RNF43 regulates EGFR or BRAF protein stability and finds no consistent evidence of such regulation, contradicting recent reports.

A Rare T-Cell Factor 4 Lineage-negative Epithelial Stem Cell Supports Wound Repair and APC-deletion-induced Colon Tumorigenesis

The paper identifies a rare Tcf4 lineage-negative stem cell population in the colon that contributes to wound repair and colon tumorigenesis when Apc is deleted.

Long-term single molecule localization microscopy uncovers dynamic co-assembly of Lrp6 and Ror2 into Wnt-signalosomes

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

KRT17 stabilizes EPN1 via inhibiting SMURF1-mediated ubiquitination to modulate Wnt/β-catenin signaling output and stem-like traits in ovarian cancer

This study identifies KRT17's role in stabilizing EPN1 by inhibiting SMURF1-mediated ubiquitination, enhancing Wnt/β-catenin signaling and stem-like traits in ovarian cancer.

Emergence of cell polarity by reciprocal interactions between Wnt and core PCP components

This study shows that Wnt11 and core PCP components interact reciprocally to establish cell polarity in Xenopus embryos without relying on Wnt gradients.

Membrane lipid composition and endocytosis modulate Wingless release from secreting cells

This study shows that membrane lipid composition and endocytosis regulate Wingless release from secreting cells by modulating its dissociation from Wntless.

Apc truncation enforces optimal Wnt signalling during early intestinal tumourigenesis

This study shows that specific Apc mutations modulate Wnt signaling activity in intestinal organoids, with optimal Wnt levels selected through additional mutations and associated transcriptional and metabolic changes.

A synNotch-based morphogen detection system reveals sFRP2 enhances Wnt3a signaling

The paper introduces a synNotch-based system to detect surface-bound morphogens and shows sFRP2 enhances Wnt3a signaling by stabilizing its surface-bound form.

Discovery of Tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain

The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.

Identification of Wnt regulated genes that are repressed by, or independent of, β-catenin

The paper identifies Wnt-regulated genes repressed by or independent of β-catenin in a cancer model, revealing a cis-regulatory motif involved in repression.

CD73 restrains mutant β-catenin oncogenic activity in endometrial carcinomas

This paper identifies CD73 as a regulator that limits oncogenic activity of mutant β-catenin in endometrial carcinomas, showing that its loss increases transcriptional activity and tumor progression.

Anti-resonance in developmental signaling regulates cell fate decisions

The paper identifies anti-resonance in Wnt signaling that suppresses mesoderm differentiation in human cells by analyzing signal frequency effects using optogenetics and modeling.

Remote Activation of Wnt Signaling and Cell Proliferation by E-cadherin Magnetomechanical Stimulation

This paper introduces a magnetogenetic toolkit to remotely activate Wnt/β-catenin signaling via E-cadherin mechanotransduction using magnetic nanoparticles and low-intensity magnetic fields.

Differential functions of multiple Wnts and receptors in cell polarity regulation in C. elegans

The paper investigates the distinct and cooperative roles of multiple Wnt ligands and receptors in regulating cell polarity orientation in C. elegans.

Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α

The paper identifies mutations in SACK1G that disrupt its interaction with CK1α, using computational modeling and experimental validation.

TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche.

This study shows TNFR1 promotes colonic mesenchymal cell diversity and stem cell niche function, with TNFR1 deficiency reducing cell diversity and impairing stem cell maintenance.