Alzheimer's disease research and treatments

An integrated Rheo-NMR platform for real-time, site-specific kinetic analysis of amyloid formation

This paper introduces a Rheo-NMR platform to analyze amyloid formation kinetics in real-time and provides insights into environment-dependent aggregation pathways.

Proximity labeling reveals unique and shared interactomes of unmodified and pyroglutamate amyloid beta in human hippocampus in Alzheimers disease

This study uses proximity labeling to compare the interactomes of pyroglutamate-modified and unmodified amyloid beta in AD and control hippocampus, identifying unique and shared protein interactions.

Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

Olfactory neuroepithelium biomarker platform: a proof from Alzheimer's disease

The paper demonstrates a non-invasive nasal swab platform with single-cell Western blotting for Alzheimer's disease biomarker detection, showing superior diagnostic performance compared to blood-based methods.

Genetic Architecture of Plasma Amyloid and Tau Biomarkers in the Amish

The paper identifies genetic variants associated with AD-related plasma biomarkers in the Amish cohort using GWAS and linkage analysis.

DNA-Encoded Library-Guided Discovery of a First-in-Class Molecular Glue of the NOS1AP-SCRIB Complex in Alzheimer's Disease Patient-Derived Neurons

This paper identifies and optimizes a molecular glue that stabilizes the NOS1AP-SCRIB interaction, showing therapeutic effects in Alzheimer's patient-derived neurons.

Spatiotemporal transcriptomic dynamic across the auditory pathway from young to old age in 5xFAD Alzheimer disease mice

The paper analyzes bulk RNA-seq data from multiple auditory regions in 5xFAD mice across ages to identify spatiotemporal gene expression changes associated with AD progression.

Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT

This study shows intranasal insulin does not reduce brain amyloid plaques in 5xFAD mice but changes intestinal morphology and fecal metaproteomics.

Surface-induced tau condensation generates a selective microenvironment around microtubules

This study shows tau forms multilayered condensates on microtubules via a prewetting-like transition, creating a selective microenvironment that restricts some proteins while recruiting others.

Depth-Dependent Alterations in Cerebral Blood and Tissue Oxygenation Associated with Tau in Alzheimer's Disease Models

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

Transcriptomic and phenotypic characterization of Alzheimer's disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms

The paper uses single-cell transcriptomics and phenotypic analysis of gene knockouts in hiPSC-derived neurons and astrocytes to identify cell-type specific and shared mechanisms of Alzheimer's disease risk genes.

The modulatory effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy-associated clearance in Aβ1-42-induced N2a cells

This study evaluates the effects of Hericium erinaceus and donepezil on amyloid accumulation and autophagy in Aβ1-42-induced N2a cells, finding synergistic effects on cell viability and protein expression.

Fine-mapping HLA-II haplotypes in Alzheimer's disease and healthy longevity reveals distinct associations with microglial HLA-II load and neuropathology

Carbonic anhydrase inhibition rescues heart function in the Tg2576 Alzheimer's mouse model by ameliorating cardiac amyloid-β pathology and neurotrophic signaling impairment.

This study shows that carbonic anhydrase inhibitors improve heart function in Alzheimer's mice by reducing amyloid-β and restoring neurotrophic signaling.

Large-Scale Mutagenesis Identifies Sequence Changes That Bias Tau Toward CTE-like Aggregation

The paper identifies sequence changes that bias tau aggregation toward CTE-like structures using mutagenesis and structural analysis.

Spatial transcriptome-metabolome integration reveals region-specific glial lipid dysregulation linked to Alzheimer's pathology

The paper develops a spatial multi-omic method to study lipid dysregulation in Alzheimer's disease across brain regions in mice, identifying region-specific glial metabolic changes.

Exacerbation of neurodegeneration by a metabolically engineered bacterium in a mouse model of tauopathy

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

Stage-specific proteomic signatures of synaptopathy in Alzheimers disease

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

Triple-Omics Analysis Unveiled the Neuroprotective Mechanisms of Akkermansia muciniphila in an Environmental Exposure-Linked Mouse Model of Alzheimer's Disease

This study identifies A. muciniphila's neuroprotective effects against Cd-induced hippocampal dysfunction through restoration of post-transcriptional RNA regulation and splicing patterns.

A First-in-Class, Brain-Penetrant Small Molecule Inhibitor of the NOS1AP-Tau Interaction Rescues Tau Pathology In Vivo and Improves Cognition

CAPTOR-1, a small molecule inhibitor of NOS1AP-tau interaction, reduces tau pathology and improves cognition in AD models.

The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1-42): a pharmacometabolomic approach

This study uses NMR-metabolomics to show CHF6467 mitigates Aβ(1-42)-induced metabolic changes in SH-SY5Y cells by promoting phospholipid precursors, reducing glutamate excitotoxicity, and restoring energy metabolism.

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.

Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time

This study examines how early-life handling and sex influence cognitive resilience and pathology in APP/PS1 mice over time, finding improved memory and reduced pathology in handled mice and better cognition in females despite greater pathology.

Templated seeding induces the formation of Alzheimer paired helical tau filaments in human brain organoids

Cortical organoids from healthy human iPSCs, seeded with Alzheimer brain tau, form three-repeat tau filaments that cryo-EM shows are identical to Alzheimer paired helical filaments and need endogenous tau.

Magnetic Field Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimers Disease an In Silico Study

This paper models how a magnetic field enhances DHA delivery to increase acetylcholine levels in Alzheimer's disease, showing significant time reduction for therapeutic effects.

Templated paired helical filament formation and tau fold-dependent inclusion morphologies in primary neurons

This study shows that primary neurons can propagate Alzheimer's disease paired helical filaments and that tau filament folds determine inclusion morphologies.

Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease

This study uses proteomic analysis in aged rhesus macaques to show that GCPII inhibition alters region-specific protein expression patterns linked to Alzheimer's disease pathology.

Distinct Aβ40 and Aβ42 co-assembly pathways with free lipids: Experiment-driven MD study

This study uses experimental and molecular dynamics methods to show that Aβ40 and Aβ42 have distinct co-assembly pathways with lipids, with lipid effects varying by isoform and lipid composition.

Increased burden of endogenous viral elements in Alzheimer's Disease compared to cognitively healthy centenarians

This study compares endogenous viral elements in Alzheimer's Disease patients and cognitively healthy centenarians using long-read sequencing, finding higher EVE burden in AD patients.