Genetics, Aging, and Longevity in Model Organisms

Rapamycin treatment during development extends lifespan and healthspan

Rapamycin treatment during early life extends lifespan and healthspan in mice and Daphnia magna by slowing development and delaying aging.

Exploiting flow cytometry for the unbiased quantification of protein inclusions in Caenorhabditis elegans

This paper introduces a flow cytometry-based method to quantify protein inclusions in C. elegans, demonstrating its applicability across multiple aggregation models and its ability to monitor inclusion dynamics under stress and aging.

Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory circuit and serotonin

This paper shows that glia in C. elegans can induce a heat shock response in peripheral cells, increasing lifespan and stress resistance, independent of neurons and neurotransmitters.

Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

The paper analyzes gene expression in multiple tissues across development and ageing in mice, finding that tissues converge in expression patterns with age, associated with loss of tissue identity.

Cold shock induces a terminal investment reproductive response in C. elegans

The paper shows that cold shock in C. elegans triggers terminal investment, increasing maternal provisioning to improve offspring survival at the expense of parental survival.

Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging

This study shows that R-loop accumulation in aging Drosophila photoreceptor neurons correlates with gene expression loss and visual function decline, and that Top3β and RNase H1 can mitigate these effects.

JWA deficiency accelerates aging through disrupting intestinal epithelial homeostasis via Notch1/PPARγ/Stat5 axis

This study identifies JWA as an aging-associated gene whose deficiency disrupts intestinal epithelial homeostasis and accelerates aging in mice through the Notch1/PPARγ/Stat5 axis.

Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite

The paper investigates molecular mechanisms of longevity in termite reproductives, finding upregulated IIS pathway genes without fat accumulation.

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

Changes in body shape implicate cuticle stretch in C. elegans growth control

The paper measures body shape and growth in C. elegans during development, finds shape changes without volume change, and models cuticle stretch as a mechanism for growth control.

Positive selection and enhancer evolution shaped lifespan and body mass in great apes

The paper identifies genes and enhancers associated with lifespan and body mass in great apes through evolutionary and molecular analysis.

Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised C. elegans

This study shows that defects in DDR pathways in C. elegans lead to protein homeostasis loss, which can be rescued by HSP-16.2, preventing motor impairment.

Models for Evaluation of Biological Age Based on Multi-omics

The paper develops transcriptome and methylation age clocks using multi-omics data from healthy individuals, achieving better accuracy than existing models.

Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans

This study shows that reduced H3K4 methylation in C. elegans shortens lifespan and reduces fertility, contradicting previous findings that suggested H3K4 methylation extends lifespan.

Opposing steroid signals modulate protein homeostasis through deep changes in fat metabolism in Caenorhabditis elegans

The paper shows that UNC-1 in C. elegans neurons modulates protein homeostasis by altering fat metabolism through neurohormonal signaling involving NHR-1 and DAF-12.

Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan

The paper analyzes lifespan variation in wild yeast isolates to identify genetic and environmental factors shaping replicative lifespan and cellular processes involved in aging.

Restricting a single amino acid cross-protects D. melanogaster from nicotine poisoning through mTORC1 and GCN2 signalling.

The paper shows that restricting a single amino acid in Drosophila increases survival during nicotine exposure through mTORC1 and GCN2 signaling pathways.

Neuronal KGB-1 JNK MAPK signaling regulates the dauer developmental decision in response to environmental stress in C. elegans

The paper identifies the KGB-1 JNK MAPK pathway as essential for dauer formation in C. elegans in response to environmental stress.

Efficacy of longevity interventions in C. elegans is determined by early life activity of RNA splicing factors

The paper shows that early life activity of RNA splicing factors and lipid metabolism determine the efficacy of longevity interventions in C. elegans.

Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

The paper develops an automated image analysis pipeline to quantify sarcopenia in C. elegans and establishes a model predicting biological age based on morphological muscle features.

A Reevaluation of the Effect of Dietary Restriction on Different Recombinant Inbred (RI) Lines of Male and Female Mice

This study reevaluates the effect of dietary restriction on four recombinant inbred mouse lines, finding that DR increased lifespan in some lines but had little or negative effects in others.

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate slows aging in mice

A cocktail of rapamycin, acarbose, and phenylbutyrate slowed aging in mice by improving health metrics and reducing age-related lesions.

Drosophila p38 MAPK Interacts with BAG-3/starvin to Regulate Age-dependent Protein Homeostasis

This study investigates how the Drosophila p38 MAPK gene influences age-dependent protein aggregation through its interaction with the Chaperone-Assisted Selective Autophagy complex.

Multi-Omic Profiling of the Liver Across Diets and Age in a Diverse Mouse Population

The paper uses multi-omics data from mice to identify gene-environment-age interactions and causal molecular networks linked to longevity.

Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes

This study examines neuroanatomical changes in Fischer 344 rats during aging and between sexes using longitudinal MRI, identifying age- and sex-related differences in brain regions associated with memory and motor control.

MRI-derived brain age as a biomarker of ageing in rats: validation using a healthy lifestyle intervention

The paper develops a rat brain age prediction algorithm using MRI and validates it through a healthy lifestyle intervention, showing reduced brain ageing with environmental enrichment and dietary restriction.

Enhancing Mask Activity in Dopaminergic Neurons Extends Lifespan in Flies

This study shows that enhancing Mask activity in specific dopaminergic neurons in flies extends lifespan and improves aging-related traits.

Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

The paper investigates intergenerational stress adaptations in C. elegans across four stress types, finding conserved physiological responses with trade-offs, but no long-term transgenerational gene expression changes.

picd-1, a gene that encodes CABIN1 domain-containing protein, interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans

This study identifies picd-1 as an interacting gene of pry-1 in C. elegans, showing its role in stress response and lifespan regulation through inhibition of CRTC-1 function.

Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation

The paper screens bioactive compounds in honey bees to show curcumin mitigates ethanol-induced lifespan reduction and DNA methylation changes.