T-cell and B-cell Immunology

Sex differences in donor T cell targeting of host splenocyte subpopulations in acute and chronic murine graft-vs.-host disease: implications for lupus-like autoimmunity

This study compares sex differences in donor T cell targeting of host splenocyte subpopulations in acute and chronic murine GVHD, finding sex-specific patterns in immune responses.

CD24 and CD27 resolve ontogeny and gradual differentiation of CD11c+ atypical memory B cells after malaria infection

This study identifies CD24 and CD27 as markers for tracking the differentiation of CD11c+ atypical memory B cells during malaria infection and defines their ontogeny.

Post-transcriptional control of homeostatic B- cell signalling by HuR is required for innate B cell maintenance and function.

This study shows that HuR-mediated post-transcriptional regulation is critical for B-1 cell homeostasis, receptor expression, and function.

Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness

The paper shows that a weak SLP-76-PLC-γ1 interaction fine-tunes TCR signal strength, optimizing T cell responsiveness by controlling PLC-γ1 activity.

Intestinal challenges shape the polarisation of protective dural memory CD4 T cells

This study shows that intestinal immunological challenges shape the polarization of dural CD4 T cells, which provide protective memory against pathogens.

Phospho-enol pyruvate carboxykinase inhibition limits inflammatory T cell activation

This study shows that PEPCK-M is upregulated in T cells during activation and that its inhibition reduces T cell effector functions and cytokine production.

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

The paper identifies transcriptional modules and cytokine signaling pathways that drive functional heterogeneity in T follicular helper cells across different infections.

Endogenous retroelements promote tolerance to dietary antigens

This study shows that endogenous retroelements promote tolerance to dietary antigens by regulating regulatory T cell function and dendritic cell activity through innate sensing pathways.

Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice

This study shows that Trsp is essential for T cell development and function, particularly regulatory T cells, and its deficiency leads to fatal autoimmunity.

Differentiation of naive into memory-phenotype CD8+ T cells does not promote the breakdown of peripheral tolerance in irradiated mice

This study shows that lymphopenia-induced proliferation and differentiation of naive CD8+ T cells into memory-like cells do not prevent cross-tolerance breakdown in irradiated mice.

FCRLs and atypical transcriptional pattern in tumor infiltrating B cells from lung and renal cancer

The paper analyzes B cell subpopulations in lung and renal cancer, finding that FCRL4 expression and IgA/IgG ratios correlate with tumor progression and poor survival.

A Rapid and Scalable Subcutaneously Administered Murine Thymus Micro-organoid for Generating Functional T cells

This paper develops a scalable subcutaneous thymus micro-organoid system that generates functional T cells in vivo and in vitro.

Leukemia escapes immunity by imposing a Type-1 regulatory program on neoantigen-specific CD4+ T cells.

This paper shows leukemia induces neoantigen-specific CD4+ T cells to become regulatory (Tr1) cells, which suppress cytotoxic T cells and promote relapse, and repolarizing these cells to Th1 states eradicates residual disease.

Glycogen synthase kinase-3 is essential for Treg development and function

This study shows that GSK3 is essential for Treg development and function, as its loss leads to metabolic changes, pro-inflammatory gene expression, and enhanced anti-tumoral immunity.

CD11c+ Tbet+ B cells constrain obesity- and vaccination-induced germinal center B cells and T helper cells

The paper shows that Tbet+ B cells in obesity suppress germinal center B and T helper cells, contributing to immune suppression and metabolic disease.

RasGRP1 Signalling Programs Developing γδ-Thymocytes towards the γδT17 Lineage Through Control of c-Maf Expression

This study shows RasGRP1 is essential for generating CD73+ γδ T cells and regulating c-Maf expression to drive γδT17 lineage commitment.

Dynamic fates of dietary antigen-specific T helper cells in a model of early life oral tolerance

This study investigates the fate of CD4+ T cells during early life oral tolerance development in mice, finding that OVA-specific Tregs and Th2 cells emerge, while Th2 cells are suppressed upon systemic challenge.

A systems approach to B-cell development identifies BDNF as a regulator of human B lymphopoiesis

This study identifies BDNF as a regulator of human B lymphopoiesis using a systems biology approach integrating single-cell transcriptomics and intercellular communication mapping.

Spatial Analysis of T Cell Clonality in Autoimmune Kidney Disease Using TRV Probes

The paper develops an in situ hybridization method to analyze T cell clonality in kidney biopsies and finds spatial clustering of clonally related T cells near antigen-presenting cells.

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

Epigenetically regulated p53 activity maintains intestinal regulatory T cell identity to prevent inflammation

This study shows that p53 activity, regulated epigenetically, maintains intestinal Treg identity and prevents inflammation by preventing Foxp3 loss in Th17 environments.

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causingautoimmune diseases through autoantibody production

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by ageing

This study identifies two postnatal thymus epithelial progenitor cell subpopulations defined by Ly6d expression, showing differential impact of ageing on their maintenance.

Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL2

This study shows Malat1 regulates cytokine expression in female Th2 cells by affecting early differentiation and IL2 response, but not in male cells.

Early-life infection with Cryptosporidium parvum induces inflammatory responses to dietary antigens

This study shows that early-life Cryptosporidium parvum infection in mice disrupts oral tolerance by altering regulatory T cell development and inducing TH1 immune responses to dietary antigens.

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice

This study shows that LCK deficiency in CD8 T cells reduces proliferation but increases effector T-cell formation in mice, revealing its dual role in T-cell responses.

Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveal a Requirement for Csf1r-Expressing Myeloid Cells During Early T Cell Development

This study identifies two mouse thymic macrophage populations and shows their role in T cell development, particularly highlighting the requirement for Csf1r-expressing myeloid cells during the DN3-to-DN4 transition.

Molecular determinants of brain-resident CD8+ T cell formation and function

This study identifies molecular factors shaping brain-resident CD8+ T cell formation and function in health and disease.

In a model of parasite-mediated exhaustion, stem-like CD8 T cells differentiate into an unconventional intermediate effector memory subset.

This study identifies distinct CD8 T cell subsets during chronic Toxoplasma gondii infection, showing a unique differentiation pathway that differs from viral and cancer models.

Chronic Infection Perturbs the Affinity Hierarchy of Antiviral B Cells

This study shows that chronic viral infection disrupts B cell affinity hierarchies by preferentially causing attrition of high-affinity B cells due to excessive antigen stimulation.