Multiple Sclerosis Research Studies

Astrocyte interferon-gamma signaling dampens inflammation during chronic central nervous system autoimmunity via PD-L1

This study shows astrocytic IFN-gamma signaling reduces inflammation in MS via PD-L1, suggesting therapeutic potential.

Voluntary muscle activation in people with Multiple Sclerosis is reduced across a wide range of forces following maximal effort fatiguing contractions

This study shows that people with relapsing-remitting MS have reduced muscle activation across various contraction forces after fatiguing contractions, linked to disease duration.

Oligodendroglial precursors orchestrate immune network instigating early demyelination in experimental autoimmune encephalomyelitis

This study identifies a network involving oligodendroglial precursors and immune cells that drives early demyelination in EAE, showing that targeting CCL4 disrupts this cycle.

Carnosine synthase deficiency aggravates neuroinflammation in multiple sclerosis

This study shows that carnosine synthase deficiency worsens neuroinflammation in MS models but not demyelination, suggesting a role in neuroinflammation regulation.

Excitable dynamics of flares and relapses in autoimmune diseases

This paper models autoimmune disease flares as excitable dynamics, showing how stochastic events trigger relapses and how regulatory cells influence their frequency.

CITE-seq reveals inhibition of NF-kB pathway in B cells from vitamin D-treated multiple sclerosis patients

The paper uses CITE-seq to analyze B cells from vitamin D-treated MS patients, identifying NF-kB pathway inhibition as a potential mechanism for vitamin D's protective effects.

Maresin-1 promotes neuroprotection and prevents disease progression in experimental models of multiple sclerosis through metabolic reprogramming and shaping innate and adaptive disease-associated cell types

This study shows that MaR1 treatment reduces inflammation, protects neurons, and improves metabolism in a mouse model of multiple sclerosis.

Pleiotropic Genetic Effects between Multiple Sclerosis and Musculoskeletal Traits

This study identifies genetic correlations and causal relationships between multiple sclerosis and musculoskeletal traits using GWAS data and Mendelian Randomization.

The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis

This study shows that the 1/f spectral slope from MEG recordings correlates with E/I ratio and cognitive function in MS patients, and is affected by benzodiazepine treatment.

Exploring the Role of Plasma Lipids and Statins Interventions on Multiple Sclerosis Risk and Severity: A Mendelian Randomization Study

This study uses Mendelian randomization to investigate the causal role of lipids and statin interventions on multiple sclerosis risk and severity, finding HDL-C increases risk while RAC2 reduces it.

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.

Wobbly hedgehog syndrome- a progressive neurodegenerative disease

This paper describes Wobbly hedgehog syndrome as a progressive neurodegenerative disease characterized by demyelination, remyelination, axonal degeneration, and neuronal loss, similar to progressive multiple sclerosis.

Mouse model of multiple sclerosis induced by disrupting vesicular transport in oligodendrocytes

This study shows that disrupting vesicular transport in adult oligodendrocytes causes demyelination and neuroinflammation, contributing to Multiple Sclerosis.

Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis

This study models lifespan brain atrophy trajectories in MS patients and healthy controls, identifying early subcortical structures affected before clinical diagnosis.

IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

A Mechanistic Insight into Sources of Error of Visual Working Memory in Multiple Sclerosis

This study investigates working memory dysfunction in multiple sclerosis using continuous reproduction paradigms, finding increased recall error and decreased precision, and identifying decoding imprecision and swap error as key factors.

Multimodally trackable and clinically translatable platform for modelling human demyelinating brain diseases by temporally dispersed chemically induced lesions in thepig brain

This paper develops a large animal model for demyelinating brain diseases using minipigs, demonstrating reversible and multimodally trackable lesions that mimic human pathology.

Combination-Based Drug Screening for Induced Oligodendrocyte Differentiation Enables Mechanistic Insight and Identifies Optimal Drug Pairs for Remyelination

The paper identifies drug pairs for remyelination using combination screening and provides mechanistic insights into their efficacy and toxicity.

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions

The paper investigates DNA methylation and transcriptomic changes in chronic demyelinated MS lesions, showing hypermethylation of myelination-related genes and demonstrating reversible effects through epigenetic editing.

Dilated Virchow-Robin Spaces are a Marker for Arterial Disease in Multiple Sclerosis

This study investigates the clinical relevance of dilated Virchow-Robin spaces (VRS) as an imaging biomarker in multiple sclerosis, finding they correlate with vascular pathology rather than immune cell accumulation.

Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response

This study investigates how combining Sephin1 and BZA accelerates remyelination under inflammation by modulating the integrated stress response in oligodendrocytes.

Syndecan-1 as specific cerebrospinal fluid biomarker of multiple sclerosis

The paper identifies Syndecan-1 as a specific cerebrospinal fluid biomarker for multiple sclerosis, improving diagnostic and prognostic accuracy compared to existing markers.

In Vivo MRI of Endogenous Remyelination in a Nonhuman Primate Model of Multiple Sclerosis

This study shows that in vivo MRI can detect remyelination in a nonhuman primate model of MS with high accuracy, suggesting its potential for preclinical and clinical applications.

Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed myelinating oligodendrocytes in PLP1 mutant mice

The paper identifies cytotoxic CNS-associated T cells as drivers of axon degeneration in PLP1 mutant mice through single-cell transcriptomics and functional experiments.

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Immunomodulatory Therapy with Glatiramer Acetate Reduces Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Experimental Autoimmune Encephalomyelitis

This study shows that glatiramer acetate reduces ER stress and mitochondrial dysfunction in EAE mice by suppressing neuroinflammation.

A Deep Transcriptome Meta-Analysis Reveals Sex-based Molecular Differences in Multiple Sclerosis

This study identifies sex-based molecular differences in multiple sclerosis through transcriptomic meta-analysis, revealing tissue-specific gene expression patterns and functional immune pathway alterations.

The proton-activated receptor TDAG8 is upregulated in oligodendrocytes during maturation and under acidic conditions.

The paper investigates TDAG8 expression and function in oligodendrocytes under acidic conditions and inflammation, finding upregulation during maturation and in MS lesions.

Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responses

This study identifies anastellin, a fibronectin-derived peptide produced by astrocytes lacking TIMP-1, which inhibits oligodendrocyte differentiation and reduces FTY720 efficacy in multiple sclerosis.