Cancer Immunotherapy and Biomarkers

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma

This study shows copper chelation enhances immune checkpoint blockade therapy in mesothelioma by altering the tumour microenvironment and increasing cytotoxic lymphocytes.

Harnessing Tumor-Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma

This paper introduces NeoAPP, a tool to identify tumor-specific transcript-derived neoantigens in PDAC, revealing a large neoantigen reservoir that could improve immunotherapy.

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer

This study identifies Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction using CRISPR screens and shows their potential as therapeutic targets.

Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Anti-Tumor Immunity In Vivo and in Patient-Derived Cells

This study identifies GL-4512, a small molecule modulator of LILRB4, which restores anti-tumor immunity in vivo and in patient-derived cells by disrupting immunosuppressive signaling.

A Novel Syngeneic Mouse Model to Study Immune Evasion in Head and Neck Squamous Cell Carcinoma

This paper develops a novel syngeneic mouse model for HNSCC to study immune evasion and evaluates its response to immunotherapies.

Mechanisms regulating combination effect of antibody-drug conjugates and cancer immunotherapy

This paper investigates the mechanisms of ADC-immunotherapy combinations, finding that ADC-induced autophagy upregulates TNFR and M6PR, driving antitumor effects through TNF and granzyme B pathways.

IOBRpy enables agentic multi-omics decoding of anti-tumor immunity

Python toolkit chains RNA-seq quantification, six-method tumour microenvironment (TME) profiling, SpecHLA typing and TRUST4 repertoire analysis with AI agents; TME outputs match R implementations (Spearman 0.986 to ~1.0).

Leveraging TNFR2 for antitumour immunity: T reg depletion and myeloid reprogramming versus T cell costimulation

This paper evaluates two TNFR2-targeting antibodies, showing ligand-blocking antibodies deplete T regs and reprogram myeloid cells, while agonists directly co-stimulate T and NK cells, both leading to anti-tumor effects.

High glucose confers senescence resistance via GLUT1 epigenetic rewiring to blunt immunotherapy responses in esophageal squamous cell carcinoma

This study identifies GLUT1 as a driver of immunotherapy resistance in ESCC by epigenetically suppressing senescence and reveals dietary glucose restriction as a potential strategy to enhance immunotherapy efficacy.

SIGLEC1 FACILITATES MACROPHAGE-CD8+ T CELL INTERACTIONS AND CORRELATES WITH CANCER IMMUNOTHERAPY RESPONSE

This study identifies SIGLEC1 as a mediator of macrophage-CD8+ T cell interactions in melanoma and shows its correlation with response to immune checkpoint blockade.

Inflammatory endothelial cells promote infiltration of antigen-licensed cytotoxic T cells in malignant gliomas after irradiation

The paper shows that irradiation reprograms tumor endothelium to enhance T cell infiltration and effector function in gliomas, improving immunotherapy outcomes.

APOBEC3G expression marks a TMB-high, T cell-inflamed tumor state and is associated with response to immune checkpoint blockade in multiple cancer cohorts

This study identifies APOBEC3G as a transcriptomic marker associated with high TMB, T cell infiltration, and response to immune checkpoint blockade across multiple cancer cohorts.

Decitabine reverses innate immune gene suppression in rare melanomas

This study identifies immune evasion mechanisms in rare melanomas and shows that decitabine reactivates innate immune pathways, improving immune responsiveness.

Confined T cell migration controls programmed cell death 1 expression

The paper shows that confined T cell migration through pores reduces programmed cell death 1 expression via ubiquitin-mediated degradation, enhancing T cell function and correlating with disease outcomes in melanoma.

Spatial Compartmentalization of TCR Repertoires Between Primary Melanomas and Sentinel Lymph Nodes Reveals Distinct Clonal Architectures and Shared Antigen Recognition

The paper analyzes TCR repertoires in melanoma tumors and sentinel lymph nodes to reveal distinct clonal architectures and shared antigen recognition patterns.

Mechanistically informed adaptive dosing for cancer immunotherapy using AI-guided decision making

This paper develops an AI-guided framework for personalized cancer immunotherapy dosing, achieving high remission rates with lower median doses compared to fixed regimens.

Targeting DNMT1 augments anti-tumor CD8⁺ T cell function

This study shows that inhibiting DNMT1 improves CD8+ T cell function in the tumor microenvironment and enhances the effectiveness of immune checkpoint inhibitors in a melanoma model.

Integrative analysis of TCGA transcriptomic states and DepMap dependencies prioritizes candidate vulnerabilities in immune-cold microsatellite-stable colorectal cancer

The paper integrates transcriptomic and dependency data to identify candidate vulnerabilities in immune-cold MSS CRC.

APOBEC3-driven neoantigen-rich cancers co-opt 1q23.3 amplification for tumor-intrinsic immune cloaking

The paper identifies a tumor-intrinsic immune-cloaking mechanism in neoantigen-rich cancers driven by APOBEC3 mutagenesis and 1q23.3 amplification, showing NECTIN4's role in suppressing immune responses.

PD-L1-linked spatial decoupling of tumour-immune interactions in EBV-positive DLBCL

The paper investigates how PD-L1 genomic gains in EBV-positive DLBCL alter spatial tumour-immune interactions, revealing immune evasion through fibroblast exclusion, metabolic suppression, and T-cell exhaustion.

Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasis

This study shows that a microbiome-dependent mechanism increases MHC-II expression in colon cancer cells, enhancing immunotherapy response and limiting metastasis.

Mapping the immune landscape in small cell lung cancer unveils a distinct tumor-reactive CD8+ T cell molecular signature

This study identifies a CD8+ T cell molecular signature specific to small cell lung cancer, showing its prognostic value and potential for immunotherapy.

Computing tumor specificity of cancer antigen targets by k-mer indexing of healthy tissue transcriptomes

The paper introduces k4neo, a tool that computes tumor specificity of transcript variants by k-mer indexing of healthy tissue RNA-seq data, identifying tumor-specific antigens across multiple cancer cohorts.

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity

The paper identifies DPP9 as a genetic susceptibility gene for checkpoint inhibitor pneumonitis and shows IL-18 blockade could be a therapeutic strategy.

Decoding Neoantigen-encoding Tumor-Specific Transcripts Unveils a Shared Target Reservoir for Immunotherapy in Hepatocellular Carcinoma

This paper identifies neoantigen-encoding tumor-specific transcripts (neoTSTs) in hepatocellular carcinoma, showing they are more abundant and immunogenic than mutation-derived neoantigens, and demonstrate therapeutic potential in preclinical models.

Immunogenic tumor mass dormancy as a driver of persistent residual lesions in immunotherapy-treated melanoma

This study shows that immunogenic tumor mass dormancy, not cell-level quiescence, persists in residual melanoma lesions after immunotherapy, with active tumor cells and immune interactions.

A Paracrine Dietary Lipid Axis Constrains Antitumor Immunity in Liver Cancer

This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

Inhibition of KDEL receptors remodels the tumor microenvironment for robust T cell independent tumor regression

The paper shows that inhibiting KDELR2 in tumor cells promotes tumor regression through innate immune activation, independent of T cells, and primes anti-tumor T cells for future challenges.