Immunotherapy and Immune Responses

Improved cross-presentation enabled by fusion-dependent mini-proteins that efficiently reach the dendritic cell cytosol

This study improves cross-presentation by using fusion-dependent mini-proteins to enhance antigen delivery to the dendritic cell cytosol, leading to better MHC-I presentation and T-cell activation.

Antigen presentation requirements for effective cDC1-based cancer immunotherapy

This study shows that in vitro-derived cDC1s resemble tumor-infiltrating DCs and that MHC-I and MHC-II antigen presentation by these cells is essential for effective cancer immunotherapy.

T-Cell Synaptosomes Orchestrate Long-Term Anti-Tumor Immunity via Proliferative and Metabolic Reprogramming

This study shows T-cell immunological synaptosomes (TIS) reprogram APCs and induce durable anti-tumor immunity in a mouse model.

Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

The paper shows microbial metabolites 5-OP-RU and 5-OE-RU activate MAIT cells to combat solid tumors by enhancing cytotoxicity, cytokine secretion, and reprogramming the tumor microenvironment.

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

High-Density Wild-Type IL-2 Nanoparticles Preferentially Enhance CD8⁺ T-Cell Expansion and Reprogram the Tumor Microenvironment

This paper develops IL2-NP nanoparticles that enhance CD8 T-cell expansion and reprogram the tumor microenvironment, showing efficacy in multiple cancer models.

AI-Informed neoantigen prioritization enables a multi-epitope mRNA/LNP vaccine with antigen-specific immunogenicity and antitumor activity

This paper develops a multi-epitope mRNA/LNP vaccine using AI-prioritized neoantigens, showing enhanced immunogenicity and antitumor activity in preclinical models.

Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastases

This study identifies conventional dendritic cells type 1 (cDC1s) as critical for anti-tumor immunity in brain metastases, showing their unique role in promoting CD8+ T cell responses and enhancing immunotherapy efficacy.

Tunable Rigid Spikes on Virus-Like Porous Silica Enable Mechanistically Controlled Nanovaccine Platforms

This paper designs tunable, rigid spike architectures on virus-like porous silica nanoparticles to enhance antigen delivery and immune response, showing improved vaccine efficacy compared to traditional adjuvants.

B cell-intrinsic IRF8 transcriptionally reprograms antigen presentation to sustain CD8⁺ T cell antitumor immunity

This study identifies IRF8 as a B cell-intrinsic regulator of antigen presentation that sustains CD8⁺ T cell antitumor immunity and predicts response to PD-1 blockade therapy.

Self-antigen disrupts cDC1 mediated antitumor responses

This study shows that self-antigen disrupts cDC1-mediated antitumor responses by altering antigen processing and cross-presentation in dendritic cells.

Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy

This paper develops a nanoparticle platform to target TLR3 agonist to antigen-presenting cells, improving cancer immunotherapy safety and efficacy by reducing systemic toxicity and enhancing tumor targeting.

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas

This study shows that combining decitabine and entinostat increases immunogenicity of low-mutation sarcomas by upregulating antigens and enhancing T cell responses.

Systemic viral vector vaccination induces brain resident memory T cells to drive anti-glioblastoma immunity

This study shows that viral vector vaccination induces brain-resident memory T cells that effectively combat glioblastoma, offering a potential therapeutic strategy.

Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer

This study shows that delivering multiple cytokine and antigen mRNAs via nanoparticles can generate strong anti-tumor immunity against pancreatic cancer in mice.

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infection

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies

The paper introduces VLP-Open HLA nanoparticles for high-throughput T cell screening, enabling efficient peptide exchange and antigen-specific T cell activation.

A transient CD87-centred axis enhances the Th17 potential of cDC2 in neonates

The paper identifies a CD87-dependent coagulation pathway that enhances Th17 potential in neonatal cDC2, with implications for early-life immunity.

Pam3CSK4 as a Cross-Species Adjuvant for Polysaccharide Vaccines: Efficacy in Humanized Mouse and Non-Human Primate Models

Pam3CSK4-based adjuvants show promise for boosting protective antibody responses to polysaccharide vaccines.

Antigen-scaffolds loaded with hyper-stable Neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

This study shows that Ag-Neo2/15 scaffolds expand antigen-specific T cells with enhanced cytotoxicity and reduced dysfunctionality compared to Ag-IL2/21 scaffolds.

mRNA-Encoded TLR5 Agonist as an Immune Adjuvant

This study tests an mRNA-encoded TLR5 agonist as an adjuvant to enhance mRNA vaccine immunogenicity and efficacy.

Coated Bacterial Vaccine Platform Overcomes Weak Antigen Immunogenicity: A Functional Approach to GnRH-Based Immunocastration

This study demonstrates that Coated Bacterial Vaccines (CBVs) enhance the immunogenicity of a GnRH-based peptide vaccine, inducing a strong Th2-biased humoral response and effective immunocastration in mice.

Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates

Age-driven Dysregulation of murine Dendritic Cells is controlled by cell-intrinsic and extrinsic effects

This study investigates age-related changes in dendritic cells across tissues, finding tissue-specific alterations in DC development and function, with preserved cell-intrinsic capabilities in aged bone marrow.

CD40 agonistic-monovalent streptavidin fusion antibody for targeted neoantigen peptide delivery and potent cancer vaccination

This paper develops a CD40 agonistic-monovalent streptavidin fusion antibody that delivers neoantigen peptides to APCs, enhancing cancer vaccine efficacy and tumor regression in mice.

Mechanical licensing of functional dendritic cell states for enhanced T cell priming

This paper shows that mechanical stress relaxation in dendritic cells (DCs) influences their functional states, enhancing T cell priming through improved antigen presentation and migration.

T cells compete via reverse MHC class I signaling at the synapse with dendritic cells to secure Golgi recruitment for activation

The paper shows that DCs use reverse MHC class I signaling to polarize their MTOC and Golgi toward T cells, enabling localized IL-12 release for T cell activation.

Covalent tumor anchoring spatially orchestrates antitumor immunity

This paper introduces CATIPs, covalently anchored tumor immunotherapeutic proteins that enhance antitumor immunity by immobilizing immune cues on tumor surfaces, showing improved efficacy and reduced toxicity in preclinical models.

Optimization of a liver Trm cell-inducing mRNA vaccine by reduction of type I interferon response

This study optimizes an mRNA vaccine to enhance liver Trm cell induction by reducing type I interferon responses through improved manufacturing.

Lung-targeted cytokine-coding RNA-lipoplexes induce T and NK cell-mediated anti-tumor immune response

This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.