Genetics, Aging, and Longevity in Model Organisms

Biological age is increased by stress and restored upon recovery

This study shows biological age can increase with stress and decrease with recovery, using epigenetic clocks in mice and humans.

Oleic acid decouples fecundity and longevity via DAF-12 steroid hormone signaling in C. elegans

This study shows that oleic acid supplementation increases fecundity in C. elegans postdauer adults via DAF-12 signaling, with complex effects on lifespan and metabolism.

The importance of reaction norms in dietary restriction and ageing research

The paper shows that reaction norm variation explains inconsistent results in dietary restriction studies and highlights the need for personalized approaches in ageing research.

Transcriptomes Often Resemble Biological Aging Upon Perturbation

The paper shows that gene length-dependent transcription decline, typically associated with aging, also occurs in response to various perturbations across many gene expression profiles.

Knockdown of Atg1 or Atg18 in adult adipocytes impairs lipophagy and reduces lifespan of fruit flies (Drosophila melanogaster)

This study shows that knocking down Atg1 or Atg18 in adult fly adipocytes impairs lipophagy and reduces lifespan, but not in muscle or glia.

Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes

TRAIL quantifies protein and cell lifetimes across tissues, showing cell division drives non-selective turnover in proliferative tissues while physicochemical features influence turnover in non-proliferative tissues.

Free long chain fatty acid solitarily primes early postembryonic development in Caenorhabditis elegans under starvation

The paper shows that palmitic acid alone can initiate early postembryonic development in C. elegans under starvation by acting as a nutrient signal through hormonal pathways, not as an energy source.

Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation

This study uses multidimensional proteomics to analyze age-related changes in yeast cells, identifying molecular trajectories of aging and rejuvenation.

Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles

The paper reanalyzes millions of molecular profiles to identify aging interventions using AI agents, finding over 500 interventions that reduce biological age and revealing patterns in aging modulation.

Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies

This study generates single-cell transcriptomic atlases of C. elegans across its lifespan under pro-longevity conditions to identify cell-type-specific aging mechanisms and regulatory changes.

Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.

Endogenous DAF-16 Spatiotemporal Activity Quantitatively Predicts Lifespan Extension Induced by Dietary Restriction

This study quantifies DAF-16 spatiotemporal activity in C. elegans under dietary restriction and finds it predicts lifespan extension with 78% accuracy.

Signaling from the C. elegans Hypodermis Non-autonomously Facilitates Short-term Associative Memory

This study shows that hypodermal insulin/IGF-1 signaling regulates memory in C. elegans through non-autonomous signaling via the Notch pathway.

Inhibition of haao-1 enhances oxidative stress response by activating hormetic redox signaling in C. elegans.

The paper shows that inhibiting haao-1 in C. elegans enhances oxidative stress resistance by activating the Nrf2/SKN-1 pathway through a hormetic redox mechanism.

Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity

This study investigates how myriocin, a sphingolipid biosynthesis inhibitor, enhances longevity by modulating ubiquitination and proteostasis networks in yeast.

Microtubule decay is a driver of neuronal ageing and a promising target for intervention

This study identifies microtubule decay as a key driver of neuronal ageing in Drosophila and shows that enhancing microtubule networks can slow age-related decline.

piRNAs regulate a Hedgehog germline-to-soma pro-aging signal

This study shows that piRNA pathway downregulation in the germline during mating releases Hedgehog signaling, leading to somatic aging and reduced lifespan.

Electron transport chain RNAi in glutamate neurons extends life span, increases sleep, and decreases locomotor activity in Drosophila melanogaster

Follicle stimulating hormone signaling opposes the DRL-1/FLR-4 MAP Kinases to balance p38-mediated growth and lipid homeostasis in C. elegans

The paper identifies a signaling network in C. elegans where DRL-1/FLR-4 MAP Kinases and opposing FLR-2/FSHR-1 signaling regulate growth and lipid homeostasis via p38/PMK-1 and PHA-4/FOXA.

Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in Drosophila

This study shows that dietary restriction in Drosophila affects diurnal rhythms and longevity through clock-controlled proteasome subunits.

Multiomic Analysis of Adult Diapause in Drosophila melanogaster Identifies Hallmarks of Cellular Quiescence

The paper identifies cellular quiescence hallmarks in Drosophila diapause using multiomic analysis of the fat body, linking chromatin reorganization and transcriptional changes to lifespan regulation.

Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity

The paper examines nine long-lived C. elegans mutants to show a strong correlation between stress resistance and longevity, driven by overlapping genetic pathways.

Aging is associated with a systemic length-driven transcriptome imbalance

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.

Fundamental limits to progression of cellular life in frigid environments

The paper shows that ROS and gene-expression dynamics set limits on yeast cell cycle progression at near-freezing temperatures.

Aging-associated changes in transcriptional elongation influence metazoan longevity.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS

This study shows that young rat plasma reduces DNA methylation age, extends lifespan, and improves health in old rats.

A deep neural network provides an ultraprecise transcriptomic clock of the short-lived fish Nothobranchius furzeri and identifies predictive genes translatable to human aging.

The paper develops a deep learning model called SA-DNN to create an ultraprecise transcriptomic aging clock in the short-lived fish N. furzeri and translates it to human aging with 3-year accuracy.

Measurements of damage and repair in aging mice and humans reveals that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions

The paper measures damage and repair rates in aging mice and humans, finding that robustness and resilience decline with age, with robustness having a greater impact on damage accumulation.

Predicting lifespan-extending chemical compounds with machine learning and biologically interpretable features

The paper uses machine learning to predict lifespan-extending compounds in C. elegans using biological features from DrugAge data, achieving 82% and 80% accuracy with GO terms and protein interactors.

Target of Rapamycin Complex 2 modulates development through Hedgehog/Patched signaling in C. elegans

The paper shows that TORC2 deficiency in C. elegans slows development through the Hh/Patched signaling pathway and the transcription factor pqm-1.