Autophagy in Disease and Therapy

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neurons

The paper shows USP30 inhibition enhances mitophagy and reduces oxidative stress in parkin-deficient neurons, with non-dopaminergic neurons being the main受益者.

Autophagy activity is inhibited by hnRNP R

The paper identifies hnRNP R as a nuclear RNA binding protein that inhibits autophagy by interacting with key autophagy proteins and shows depletion of hnRNP R activates autophagy flux.

Influenza Virus-Induced Autophagy Is Not Always Associated with MUC1 Expressions

The paper investigates the relationship between influenza virus-induced autophagy and MUC1 expression in cancer cells, finding that autophagy markers and MUC1 are upregulated in influenza-positive cells.

De novo lipogenesis fuels adipocyte autophagosome membrane dynamics

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

AI-guided screen identifies probucol-mediated mitophagy enhancement through modulation of lipid droplets

The paper identifies probucol as a mitophagy enhancer through AI-guided screening, showing it improves dopaminergic neuron survival in models of mitochondrial damage.

Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons

This study identifies MTMR5 as a neuron-specific autophagy suppressor, showing its role in limiting autophagy and its potential as a therapeutic target for neurodegenerative diseases.

EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

Autophagy slows the aging of Germline stem cells in Drosophila through modulation of E-cadherin

This study shows that increasing autophagy in Drosophila female germline stem cells delays aging but can lead to cell death if sustained, with E-cadherin playing a key role in maintaining stem cell niche interactions.

NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast

The paper shows that the yeast exportomer complex inhibits Atg36 phosphorylation to prevent pexophagy, revealing a mechanism linking organelle biogenesis to autophagy regulation.

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

Exercise and training regulation of autophagy markers in human and rodent skeletal muscle.

This study compares exercise-induced changes in autophagy markers in human and rodent skeletal muscle, finding differences in LC3B-II protein levels and autophagy flux responses.

Neuronal mitochondria transport Pink1 mRNA via Synaptojanin 2 to support local mitophagy

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEB-induced Autophagy-Lysosomal Pathway

This study shows that SB202190 activates PERK, which enhances TFEB activity and the autophagy-lysosomal pathway, reducing amyloidogenesis in neurodegenerative diseases.

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

3,3'-Diindolylmethane induces apoptosis and autophagy in fission yeast

This study shows that DIM induces apoptosis and autophagy in fission yeast in a dose-dependent manner, with autophagy contributing to cell survival against DIM.

Alzheimer's disease alters astrocytic functions related to neuronal support andtranscellular internalization of mitochondria

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

Lysosomal dysfunction impairs mitochondrial quality control and predicts neurodegeneration in TBCKE

This study shows that TBCK mutations impair mitochondrial quality control via lysosomal dysfunction, correlating with neurodegeneration severity.

KANSL1 Deficiency Causes Neuronal Dysfunction by Oxidative Stress-Induced Autophagy

This study shows that KANSL1 deficiency leads to oxidative stress-induced autophagy, causing synaptic dysfunction and neuronal network impairments in neurons.

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

LC3B phosphorylation regulates FYCO1 binding anddirectional transport of autophagosomes

This study shows that LC3B phosphorylation by STK4 regulates FYCO1 binding and directional transport of autophagosomes, switching their movement from retrograde to anterograde under starvation conditions.

PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration

This study shows that PALB2 maintains redox and mitochondrial homeostasis in the brain and works with ATG7 to prevent p53-dependent neurodegeneration.

QTL analysis of macrophages from an AKR/JxDBA/2J intercross identified the Gpnmb gene as a modifier of lysosome function

This study identifies Gpnmb as a modifier of lysosome function in macrophages using QTL analysis in an AKR/JxDBA/2J intercross, showing its impact on proteolysis but not cholesterol metabolism.

V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis

This study shows that V-ATPase inhibition reduces tumor growth and restores autophagy in a Drosophila glioma model and human glioblastoma neurospheres.

Mechanism of riboregulation of p62 protein oligomerisation by vault RNA1-1 in selective autophagy

The paper identifies the molecular mechanism by which vault RNA1-1 regulates p62 oligomerisation, essential for selective autophagy.

Autophagy-related genes atg7 and beclin1 are essential for energy metabolism and survival during the larval-to-juvenile transition stage of zebrafish

This study shows that autophagy genes atg7 and beclin1 are critical for energy metabolism and survival during the larval-to-juvenile transition in zebrafish, as their loss leads to early death due to metabolic stress.

G9a/GLP methyltransferases inhibit autophagy by methylation-mediated ATG12 protein degradation

This study shows G9a/GLP methyltransferases inhibit autophagy by methylating and degrading ATG12, but their degradation under stress allows ATG12 accumulation and autophagy activation.

Natural LXRβ agonist stigmasterol confers protection against excitotoxicity after hypoxia-reoxygenation (H/R) injury via regulation of mitophagy in primary hippocampal neurons

This study shows that stigmasterol protects hippocampal neurons from hypoxia-reoxygenation injury by inducing mitophagy through LXRβ activation.

Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum

This study shows that neuronal autophagy regulates axonal ER calcium stores to control neurotransmission and postnatal viability in mice.