Telomeres, Telomerase, and Senescence

Long telomere inheritance through budding yeast sexual cycles

The paper investigates telomere length inheritance in budding yeast, showing that long telomeres can persist through multiple generations without mutations.

Topsicle: a method for estimating telomere length from whole genome long-read sequencing data

Topsicle estimates telomere length from whole genome long-read sequencing data using k-mer and change point detection, showing robustness and accuracy in plant and human cancer cells.

TERRA R-loops trigger a switch in telomere maintenance towards break-induced replication and PrimPol-dependent repair

This study shows that TERRA R-loops induce ALT-like telomere repair through BIR and PrimPol-dependent mechanisms in telomerase-expressing cells.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

DNA methylation protects cancer cells against senescence

The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.

Human mitochondrial DNA variants influence telomere length: evidence from a transmitochondrial cybrid model

The paper investigates how mitochondrial DNA variants affect telomere length using transmitochondrial cybrids, finding an inverse correlation between donor telomere length and mitochondrial ROS levels.

JMJD3 mediated senescence is required to overcome stress induced hematopoietic defects.

This study shows JMJD3 promotes senescence in HSPCs to overcome stress-induced hematopoietic defects, with implications for aging and cancer therapies.

Cell-Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis

The paper identifies LAMP1 as a cell-surface biomarker for senescent cells in aging and idiopathic pulmonary fibrosis and demonstrates its targeting using a dual antibody-drug conjugate.

Identification of senescence-related hub genes and potential therapeutic agents for chronic heart failure

This study identifies nine senescence-related hub genes and potential therapeutic agents for chronic heart failure using bioinformatics and experimental validation.

Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the alternative lengthening of telomeres pathway

The paper shows orphan nuclear receptors recruit TRIM28 to increase H3K9me3 at telomeres, promoting the alternative lengthening of telomeres pathway in human cells.

Telomeric Repeat-Containing RNA Increases in Aged Human Cells

This study identifies TERRA RNA upregulation in aged human cells and links it to aging and Alzheimer's disease.

Molecular and Phenotypic Characterization of Telomere Repeat Binding (TRBs) Proteins in Moss: Evolutionary and Functional Perspectives

This study characterizes TRB proteins in moss to explore their evolutionary conservation and functional roles in telomere maintenance and plant development.

Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency

This study shows that high telomeric SUMO levels promote APB nucleation and enhance ALT efficiency through BLM recruitment and DNA synthesis.

Membrane transporter Progressive Ankylosis Protein Homolog (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing.

This study identifies ANKH/Ank as a novel regulator of senescence-derived extracellular citrate in humans and mice, showing its regulation by DNA damage, inflammation, and ageing.

Polygenic modifiers of expressivity in telomere biology disorders

This study identifies polygenic modifiers of expressivity in telomere biology disorders by showing how common and rare genetic variants interact to influence clinical variability.

A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.

The paper establishes a senotype of doxorubicin-induced senescence in postmenopausal human ovarian tissue using single nuclei sequencing and proteomics.

Why are telomeres the length that they are? Insight from a phylogenetic comparative analysis

The paper investigates the evolutionary factors influencing telomere length across vertebrates and finds no direct link between body mass, lifespan, or metabolism but identifies an interactive effect between metabolism and body mass, along with a positive correlation between telomerase activity and telomere length.

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1

This study introduces two RTEL1 mouse models with distinct mutations at amino acid 492, showing that M492K affects telomere length while M492I impairs telomere protection, leading to different disease phenotypes.

SLX4IP acts in parallel to FANCM to limit BLM-dependent replication stress at ALT telomeres

This study identifies SLX4IP as a suppressor of BLM-driven replication stress at ALT telomeres and reveals its parallel function with FANCM to regulate telomere maintenance.

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish

This study shows that telomeric antisense oligonucleotides reduce premature aging in telomerase mutant zebrafish by inhibiting DDR signaling.

DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres

This study shows DNA2 and FANCM function in distinct pathways to suppress replication stress at ALT telomeres, with their combined depletion causing synthetic lethality in ALT+ cancers.

Levels of telomerase in cancer are contingent on senescence and inflammation at bulk tissue and single-cell spatial resolution

The paper quantifies telomerase activity in cancer using an unsupervised metric and finds that high levels correlate with genomic instability while low levels link to senescence, inflammation, and better survival.

Unveiling the Biochemical Mechanisms of Aging and the Implications of Oxidative Stress on Cellular Senescence through Multi-Omics Analysis of Fibroblasts

This study uses multi-omics analysis of human fibroblasts to show that mitochondrial dysfunction and epigenetic changes drive aging, with specific treatments affecting cellular lifespan and metabolic balance.

KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma

This study shows that KRAS inhibition can reverse chemotherapy resistance in PDAC by targeting therapy-induced senescence-like cells, with ERK pathway involvement.

Telomerase reverse transcriptase is required for resistance to mycobacterial infection

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.

γδ T Cells Target and Ablate Senescent Cells in Aging and Alleviate Pulmonary Fibrosis

This study shows γδ T cells eliminate senescent cells in aging and reduce pulmonary fibrosis by targeting senescent cells in mice and humans.

A Chromosome End Without Terminal Telomere Repeats is Stable for Multiple Cell Divisions.

This study shows that Schizosaccharomyces pombe can maintain chromosome ends with short, non-telomeric sequences for multiple divisions without telomerase.

Robust Binding Capability and Occasional Gene Loss of Telomere-Binding Proteins Underlying Telomere Evolution in Nematoda

The paper investigates how telomere repeats evolved in nematodes despite the specificity of telomere-binding proteins, finding that protein conservation and binding affinity correlate with the emergence of novel telomeric motifs.

Telomerase RNA gene duplications drive telomeric repeatdiversity and evolution in Andrena bees

The paper identifies multiple TR gene copies in Andrena bees that generate diverse telomeric repeats, showing TR gene duplication drives telomere sequence diversity in insects.