interferon and immune responses

Differential assembly of RNP granules via activation of distinct dsRNA sensors by adenovirus mutants

This study shows adenovirus mutants differentially activate dsRNA sensors, leading to distinct RNP granule assemblies via PKR and OAS3/RNase L pathways.

IFNγ at the crossroads of systemic protection and brain vulnerability to coronavirus infection

This study investigates the dual role of IFNγ in coronavirus infection, showing it limits systemic viral spread but increases brain vulnerability, suggesting potential therapeutic modulation.

Regulation of Chlamydia trachomatis infection in the female genital tract by type I and type II interferons

This study shows type I and II interferons have distinct and overlapping roles in controlling Chlamydia trachomatis infection in the female genital tract, with type I acting earlier and type II later, and both critical for suppression at different stages and locations.

Coronavirus papain-like protease antagonizes innate immunity by cleaving Importin α1 to disrupt nuclear transport

This paper identifies that coronavirus PLpro-TM cleaves Importin α1 to disrupt nuclear transport and suppress antiviral immunity, revealing a conserved immune evasion strategy across coronaviruses.

Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state

The paper shows that single-cell heterogeneity in IFN induction potential is heritable and driven by baseline variation in JNK and AP-1 signaling states.

Pharmacological interrogation of crosstalk between TLR signaling and stress granules reveals a compound with antiviral effect.

The paper screens TLR signaling inhibitors to identify compounds affecting stress granules and finds PPM18, which inhibits Influenza A Virus without relying on stress granule formation.

The antiviral GTPase MxB is packaged into virions and binds via its N-terminal domain to alphaherpesvirus capsids

The paper shows that MxB's N-terminal domain binds to herpesvirus capsids and is packaged into virions, restricting HSV-1 and PrV infections.

Human coronavirus nucleocapsid proteins have disparate innate immune evasion abilities

This study compares the innate immune evasion abilities of nucleocapsid proteins from different human coronaviruses, finding significant functional and mechanistic differences.

Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis

This study identifies the IFN-STAT1/STAT5B-SOCS1 axis as a mechanism by which respiratory viruses activate autophagy, showing that targeting this pathway can inhibit virus replication without compromising innate immunity.

The paraspeckle protein NONO potentiates the antiviral innate immune response through chromatin regulation

This study identifies NONO as a critical facilitator of antiviral innate immune response by promoting chromatin accessibility and IFN-I/ISG expression.

How p53 stress memory could redirect JAK/STAT1 antiviral signalling: a model-based prediction.

The paper develops a model-based analysis of how p53 stress memory influences JAK/STAT1 antiviral signaling, showing it redistributes STAT1 activity and affects viral control outcomes.

The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infection

This study identifies the RIG-I/MDA5-MAVS-IRF3 axis as the pathway sensing TONV infection and activating the IFN-I response to restrict viral replication.

Targeted Lipid Metabolism Screening Uncovers Regulatory Effects on the STING Immune Response in Mevalonate, Eicosanoid and Fatty Acid Pathways

The paper screens lipid metabolic pathways to identify how they regulate the STING immune response, finding that perturbations in mevalonate, eicosanoid, and fatty acid pathways modulate STING signaling.

Tetherin enforces an immunometabolic checkpoint that coordinates glycolytic and interferon signaling in adipocytes

This study identifies Tetherin as an immunometabolic checkpoint in adipocytes that restricts type I interferon signaling while preserving glycolytic capacity, improving metabolic homeostasis.

TBK1 and IKKϵ protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism

This study shows that TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing by suppressing inflammatory apoptosis and NFκB-driven inflammation.

Distinct roles for DNA- and RNA-sensing immune pathways in control of genital HSV-2 infection and restriction of neuroinvasion

This study shows that DNA- and RNA-sensing immune pathways differently control genital HSV-2 infection and prevent neuroinvasion.

Restraint of Powassan virus replication by TRIM5α facilitates viral avoidance of antiviral immunity

The paper investigates how TRIM5α restricts orthoflavivirus replication and identifies a mutation in POWV's NS3 gene that allows it to evade TRIM5α inhibition.

A distinct signature of interferon-stimulated genes linked to cross-protection against secondary viral infections in primary bronchial epithelial cells

TRIM52 downregulates IFN-β production by targeting TBK1 for proteasome degradation.

This study identifies TRIM52 as a negative regulator of IFN-β production by promoting TBK1 ubiquitination and proteasomal degradation.

TLR3 Activation of Microglia-Containing Cerebral Organoid Induces Antiviral Factors against HIV-1 Infection

This study shows that TLR3 activation in human iPSC-derived microglia-containing cerebral organoids induces antiviral factors against HIV-1.

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways

The paper systematically identifies effector functions of pathogen ORFs across multiple pathways, revealing new roles for known effectors and uncharacterized proteins.

Viral infection drives cell-intrinsic re-localization of the C. elegans immune-repressive STAT transcription factor STA-1

This study shows that C. elegans STA-1, a STAT-like protein, relocalizes from nuclei to cytoplasm during viral infection, acting cell-intrinsically to repress anti-viral defense.

Integrative Modelling of Innate Immune Response Dynamics during Virus Infection

This paper develops a mathematical model of virus-host interactions during RNA virus infection, revealing how immune dynamics and viral strategies determine infection outcomes.

Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import

The paper identifies SLC7A1 as the transporter for cGAMP and its analogs in T cells, showing that targeting this transporter can reduce toxicity without affecting arginine transport.

USP24 is an ISG15 cross-reactive deubiquitinasethat mediates IFN-I production by de-ISGylatingthe RNA helicase MOV10

This study identifies USP24 as a novel ISG15 cross-reactive deubiquitinase that de-ISGylates MOV10 to negatively regulate IFN-I production.

Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.

This study investigates how the HUSH complex suppresses the type I interferon pathway in human pluripotent cells, revealing its role in preventing self-nucleic acid sensing and maintaining immune evasion.

Single cell in vivo analysis of type I IFN and NK cell-mediated control of B cell infection densities during acute gammaherpesvirus infection

This study uses in vivo single-cell analysis to show that type I IFN signaling and NK cells limit MHV68 infection in lymph nodes, with IFNAR deficiency increasing infected B cell numbers and NK cell depletion enhancing viral spread.

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

The paper shows that cell death, not type-1 interferons, limits Chandipura virus propagation at high multiplicity of infection.

Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages

The paper shows that type I interferon primes alveolar epithelial cells for regeneration by enhancing their response to reparative signals from tissue-resident macrophages after viral infection.

Human interferon stimulated genes target ancient features of animal and bacterial viral replication

The paper shows human ISGs can restrict bacterial phage replication, revealing conserved antiviral mechanisms across kingdoms.