Mitochondrial Function and Pathology

Modeling of ATP Transport in an Axon: Effects of Spontaneous Neuron Firing and Mitochondrial Transfer via Tunneling Nanotubes

This study uses computational simulations to examine ATP transport in axons, showing that spontaneous neuronal firing stabilizes ATP levels and that a single mitochondrion can supply ATP to neighboring boutons, but ATP concentration declines with more empty boutons.

Single-Cell Sequencing Identifies the Crucial Role of Mitochondrial Fission-Fusion Balance in Cardiac Hypertrophy Progression

The paper uses single-cell and bulk RNA sequencing to compare pathological and physiological cardiac hypertrophy, finding that mitochondrial fission genes drive pathological progression.

Disruption of Mitochondrial Dynamics and Stasis Leads to Liver Injury and Tumorigenesis

This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.

Swiprosin-1/EFhd2 promotes mitochondrial spare capacity in response to immobilized antigen in B cells via microtubule stabilization

This study shows EFhd2 promotes mitochondrial spare capacity in B cells during immune synapse formation by stabilizing microtubules.

Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis

This study investigates how germline and somatic genetic variations affect mitochondrial DNA content, mutation patterns, and gene expression in liver tumors across four mouse strains.

Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2

This study identifies a charged glutamate on VDAC1 and VDAC2 that interacts with HKI's N-terminal helix, revealing structural and mechanistic insights into their complex formation.

Berberine is a novel mitochondrial calcium uniporter (MCU) inhibitor that disrupts MCU-EMRE assembly

This study identifies Berberine as a mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly and reduces mitochondrial calcium overload in mice.

MCU-enriched dendritic mitochondria regulate plasticity in distinct hippocampal circuits

This study shows that MCU regulates synaptic plasticity specifically at CA2 distal dendrites by maintaining mitochondrial morphology and distribution, with loss of MCU causing LTP deficits and mitochondrial fragmentation.

Restoration of mitochondrial function to metabolically stressed astrocytes by fusion with mesenchymal stromal cells.

This study shows that stressed astrocytes can restore mitochondrial function through fusion with mesenchymal stromal cells, as evidenced by mitochondrial DNA transfer and long-term functional recovery.

Mitotyping - An integrative framework to quantify mitochondrial specialization and plasticity

The paper introduces a framework to quantify mitochondrial specialization and plasticity using transcriptomic data across various contexts.

The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.

Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance

The paper investigates how mtDNA damage affects polymerase gamma activity and mtDNA stability in yeast, showing that exonuclease activity drives damage-induced mtDNA clearance.

Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import

The paper uses cryo-electron tomography to study cytoplasmic ribosome orientation and clustering on mitochondria in yeast, revealing their role in co-translational protein import.

Mdm38/LETM1 couples ion homeostasis and proteostatic mechanisms in the inner mitochondrial membrane

This study identifies Mdm38/LETM1 as a protein that links ion homeostasis and proteostasis in the mitochondrial inner membrane in yeast.

Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance

This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.

Altered endothelial mitochondrial Opa1-related fusion in mouse amplifies age-associated vascular and kidney damages

This study shows that reduced Opa1 in endothelial cells of old mice worsens vascular function and increases kidney oxidative stress.

Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis

This study shows that mitochondrial dysfunction in monocytes of severe alcohol-related hepatitis patients contributes to immune deficiency.

NCBP2-AS2 is a mitochondrial microprotein, regulates energy metabolism and neurogenesis, and is downregulated in Alzheimer's disease

AMP accumulation during mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

Bi-allelic variants in the aminopeptidase XPNPEP3 cause mitochondrial disease with pediatric cardiomyopathy

This study identifies bi-allelic XPNPEP3 variants causing mitochondrial disease with pediatric cardiomyopathy, revealing impaired mitochondrial protein processing as the underlying mechanism.

CDK4 inactivation balances resistance to apoptosis with heightened metabolic sensitivity in triple negative breast cancer cells

This study shows CDK4 inhibition in TNBC cells reduces apoptosis sensitivity and disrupts mitochondrial calcium signaling through MERCs, contributing to resistance to CDK4/6 inhibitors.

COA5 has an essential role in the early stage of mitochondrial complex IV assembly

The paper identifies a COA5 missense variant causing isolated mitochondrial complex IV assembly impairment in two siblings and validates its role in early CIV assembly using patient-derived cells and CRISPR/Cas9 knockout models.

Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons

This study shows Fis1 depletion reduces dendritic mitochondrial length and alters mitochondrial function, leading to increased calcium levels and changes in dendritic branching and spine density.

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo

This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.

A novel C. elegans respirometry assay using low-cost optical oxygen sensors

This paper introduces a low-cost respirometry assay for C. elegans using optical oxygen sensors and fluorescence readers, showing it can accurately measure OCR and identify issues with sequential respiratory inhibitor use.

A transcription network underlies the dual genomic coordination of mitochondrial biogenesis

The paper identifies a transcriptional network regulating mitochondrial biogenesis in Drosophila by combining RNAi screening and ChIP-seq analysis, revealing key factors like CG1603 and YL-1.

Quantitative analyses of single mitochondrial structure-function heterogeneity uncovers stemness specification by redox-tuned small-mitochondrial-networks

The paper quantifies mitochondrial structure-function heterogeneity, identifying redox-tuned small-mitochondrial-networks that specify stemness and are detectable in patient transcriptomes.

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

The paper creates a mitochondrial respiration atlas across 33 tissues in young and old mice, revealing age and sex effects on mitochondrial function.

Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in humans

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression

The paper maps tissue-specific mtDNA heteroplasmy and its associations with age and mtDNA gene expression using bulk RNAseq data from GTEx.