Congenital heart defects research

Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

This study identifies genetic and molecular factors underlying atrial septal defects in mice using QTL mapping and transcriptome analysis, revealing complex networks and non-coding variants involved.

The Translation Initiation Factor Homolog, eif4e1c, Regulates Cardiomyocyte Metabolism and Proliferation During Heart Regeneration

This study identifies eif4e1c's role in zebrafish heart development and regeneration by showing its impact on cardiomyocyte metabolism and proliferation through translation regulation.

Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart

This study identifies SLC25A1 as a dosage-dependent regulator of metabolic reprogramming and heart development, linking mitochondrial function to cardiac morphogenesis and congenital heart disease.

Torsion of the heart tube by shortage of progenitor cells : identification of Greb1l as a genetic determinant of criss-cross heart in mice

The paper identifies Greb1l as a genetic determinant of criss-cross heart in mice by showing its role in maintaining precursor cells during heart tube elongation.

Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes

Spatial transcriptome profiling uncovers metabolic regulation of left-right patterning

The paper identifies metabolic regulation in left-right patterning using spatial transcriptome data, linking glycolysis and Bmp7 to heart and gut looping.

Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction

This study investigates how shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction in chick embryos.

CHD-associated enhancers shape human cardiomyocyte lineage commitment

The paper identifies enhancers linked to congenital heart defects that, when repressed, impair human cardiomyocyte differentiation.

Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration

This study shows that endothelial Brg1 regulates Notch signaling in zebrafish heart regeneration by modulating H3K4me3 levels and interacting with Kdm7aa.

SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2

The paper shows SOX7 deficiency causes ventricular septal defects by impairing endocardial-to-mesenchymal transition through reduced Wnt4 and Bmp2 expression in developing atrioventricular canals.

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors

The paper identifies a Mesp1-dependent developmental breakpoint in cardiac precursor cell specification using single-cell transcriptomics and chromatin accessibility analysis in mouse embryos.

A cooperative response to endocardial NOTCH signaling stimulation regulates transcriptional activity during cardiac valve development and disease

This study identifies NOTCH-dependent transcriptional and chromatin changes in mouse endocardium during valve development and disease, revealing cooperative interactions with the HIPPO pathway.

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

This study examines cardiomyocyte ploidy dynamics in two mouse strains, revealing differences in developmental progression and identifying new roles for Runx1 and Tnni3k in ploidy regulation.

The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

This study identifies pCharme, a lncRNA that regulates cardiomyocyte maturation by forming nuclear condensates and controlling cardiac development in mice.

Translational control of furina by an RNA regulon is essential for heart morphogenesis and cardiac valve function

The paper identifies an RNA regulon involving the 3UTR of FurinA and Ybx1 that regulates translational repression, essential for heart morphogenesis and valve function in zebrafish.

Cardiac progenitors auto-regulate second heart field cell fate via Wnt secretion

The paper identifies cardiac progenitors as a source of Wnts that regulate second heart field development through secretion, using genetic manipulation and single-cell RNA sequencing in mice.

Conditional, tissue-specific CRISPR/Cas9 vector system in zebrafish reveal the role of neuropilin-1b in heart regeneration

This paper introduces a conditional CRISPR/Cas9 system in zebrafish to study neuropilin-1b's role in heart regeneration, finding it critical for cardiac function after injury.

Single cell evaluation of endocardial HAND2 gene regulatory networks reveals critical HAND2 dependent pathways impacting cardiac morphogenesis.

The paper evaluates HAND2 gene regulatory networks in endocardial cells using single-cell transcriptomics to identify HAND2-dependent enhancers and their impact on cardiac morphogenesis.

Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through alpha5 integrin signaling

This study shows that actomyosin contractility promotes cardiomyocyte proliferation by increasing Yap nuclear translocation via alpha5 integrin signaling in the postnatal heart.

Molecular characterization of Left-Right symmetry breaking in the mouse embryo

This study identifies asymmetrically expressed genes in the mouse cardiac crescent during left-right symmetry breaking using single-cell RNA sequencing and validates their expression patterns.

High cardiomyocyte diversity in human early prenatal heart development

The paper characterizes human prenatal cardiomyocytes using single-cell RNA sequencing and spatial transcriptomics, identifying eight distinct types with location-dependent properties and ligand-receptor interactions.

Coronary vessel assembly involves patterned endocardial sprouting and tip-cell-to artery specification

This study identifies endocardial sprouting angiogenesis as a key mechanism in coronary vessel formation, revealing distinct molecular profiles that shape coronary arteries and veins.

leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts

The paper identifies lepb and its enhancer as markers for regenerative cell types in zebrafish hearts using single-cell RNA sequencing and chromatin accessibility analysis.

Inhibition of adrenergic b1-AR/Gas signaling promotes cardiomyocyte proliferation through activation of RhoA-YAP axis

This study shows that inhibiting β1-AR/Gs signaling promotes cardiomyocyte proliferation and cardiac regeneration in mice by activating the RhoA-YAP axis.

Deciphering transcriptional networks during human cardiac development

The paper identifies transcriptional regulatory networks during human cardiac development by analyzing transcriptomic profiles and uncovering novel interactions among key transcription factors.

The epigenetic modifier DOT1L regulates gene regulatory networks necessary for cardiac patterning and cardiomyocyte cell cycle withdrawal

This study shows that DOT1L regulates specific gene networks in cardiac development and cell cycle withdrawal through H3K79me2 modifications.

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

This study uses single-cell chromatin accessibility analysis to identify developmental trajectories and non-coding mutations associated with congenital heart disease.

Neuregulin-1 regulates cardiomyocyte dynamics, cell cycle progression, and maturation during ventricular chamber morphogenesis

This study identifies Nrg1-ErbB2/4-pErk signaling as critical for cardiomyocyte cell cycle progression, migration, and trabeculation during ventricular development, with implications for cardiac regeneration.

Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4.

Purkinje cardiomyocytes of the ventricular conduction system are highly diploid but not regenerative

The paper identifies Purkinje cardiomyocytes as a diploid subpopulation in the ventricular conduction system that lacks regenerative capacity despite their diploid status.