Alzheimer's disease research and treatments

Brain-Penetrating Peptide and Antibody Radioligands for Proof-of-Concept PET Imaging of Fibrin in Alzheimer's Disease

This paper develops and evaluates PET radioligands targeting fibrin in Alzheimer's disease brains, showing that bispecific antibodies have better fibrin selectivity and brain penetration than peptide conjugates.

Antibodies raised against a structurally defined Aβ oligomer mimic protect human iPSC neurons from Aβ toxicity at sub-stoichiometric concentrations

This paper shows that an antibody targeting a structurally defined Aβ oligomer mimic protects human iPSC neurons from Aβ42 toxicity at low antibody-to-Aβ ratios.

The interaction between aging and DNA damage influences the accumulation of APP in Alzheimer's disease

The paper shows that DNA damage increases with age and correlates with higher APP levels in Alzheimer's disease, suggesting DNA damage drives APP accumulation.

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer Disease Model

This study shows PARP1 inhibition reduces amyloid pathology, neurodegeneration, and cognitive decline in a mouse model of Alzheimer's disease.

Modeling interaction between focal cerebral ischemia and Alzheimer`s Disease Pathology in an APP/PS1 Mouse Model

This study develops a novel mouse model to investigate the interaction between focal cerebral ischemia and Alzheimer's Disease pathology, finding an additive effect on memory and hippocampal function.

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

A Novel Mechanism for Tauopathy in Progressive Multiple Sclerosis: Excitotoxic Misplacement of a Mitochondrial Anchor into Dendrites Driven by Tau-hyperphosphorylation

This paper proposes a novel mechanism linking tauopathy to progressive multiple sclerosis through DSI, suggesting repurposing ASO therapy from Alzheimer's to MS.

G1899, an American ginseng extract, alleviates neuroinflammation and cognitive impairment in models of Alzheimer's disease

This study evaluates G1899, an American ginseng extract, showing it reduces neuroinflammation, improves cognitive function, and clears amyloid-beta in Alzheimer's disease models.

APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transition

This study identifies APOE4-driven pericyte-to-myofibroblast transition in cerebrovascular disease, leading to fibrosis and amyloid deposition, and shows TGF-β inhibition can reverse these effects.

Analyses of exon 4a structure reveal unique properties of Big tau

The paper analyzes the biophysical properties of exon 4a in tau proteins, showing it introduces a highly acidic, hydrophilic module that reduces aggregation potential compared to LMW tau.

In Silico Design of APOE ε4 Interaction Inhibitor Peptides for Alzheimer's Disease

This paper uses AI to design peptides that inhibit the APOE ε4-APP interaction, showing they bind effectively and disrupt complex formation in simulations.

APOE Genotype Influences on The Brain Metabolome of Aging Mice - Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 Genotype.

This study examines how APOE genotypes affect brain metabolome changes with aging in mice, finding that APOE2 genotype is associated with better mitochondrial function and BCAA utilization.

Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation

This study examines how acetylation and phosphorylation mutations affect tau aggregation and seeding in Alzheimer's and PSP models.

Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation.

The paper investigates the correlation between phosphorylation at serine 214 and tau seeding activity in mouse models, showing its role in tau propagation.

Protective mechanisms against Alzheimer's Disease in APOE3-Christchurch homozygous astrocytes

This study identifies how APOE3-Christchurch astrocytes protect against Alzheimer's by enhancing tau clearance and reducing harmful lipids.

APOE genotype-dependent differences in human astrocytic energy metabolism

This study investigates how different APOE genotypes affect human astrocytic energy metabolism, finding reduced ATP production in APOE4 astrocytes but increased mitochondrial respiration and glycolytic capacity.

Zolpidem restores sleep and slows Alzheimer's progression in a mouse model

Zolpidem improves NREM sleep and reduces Alzheimer's progression in young APP/PS1 mice by restoring sleep rhythms and reducing amyloid plaques.

β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity

This study shows that β-amyloid induces microglial GPC4 and APOE, which increases neuronal tau pathology and toxicity.

Neurovascular Large artery dilatation increases the risk for Alzheimer's disease pathology

This study induces dolichoectasia in a mouse model of Alzheimer's disease and finds it accelerates amyloid plaque formation and neuronal loss.

G3BP1 Maintains Lysosomal Homeostasis to Limit Tau Aggregate Accumulation

This study identifies G3BP1 as a regulator of lysosomal homeostasis that limits Tau aggregate accumulation in neurodegenerative diseases.

Modified tau leads to neuronal and global ribosome dysfunction in C. elegans model of tauopathy

The paper shows that modified tau in C. elegans causes neuronal and global ribosome dysfunction, reducing translation and lifespan, without direct ribosome association.

GSDME unlocks astrocyte-driven neurotoxicity in Alzheimer's Disease

This paper identifies GSDME as a key mediator of astrocyte-driven neurotoxicity in Alzheimer's Disease, showing its role in linking calcium dysregulation to inflammation and cognitive decline.

Lepr Haploinsufficiency Accelerates Alzheimer-like Neurodegeneration via CDK5 Hyperactivation

This study shows that Lepr haploinsufficiency accelerates Alzheimer-like neurodegeneration in mice through CDK5 hyperactivation and identifies pathogenic LEPR variants in humans.

Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer's disease patient

This study shows lithium chloride reduces iron dysregulation and ferroptosis in ApoE4/E4 iPSCs from a sporadic Alzheimer's patient, improving cell viability and mitochondrial function.

Chronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer's disease-like pathology

The paper shows that sustained neuronal hyperactivity in wild-type and AD-like mice leads to proteomic changes similar to AD pathology, including memory loss and increased Aβ42 secretion.

In vivo inhibition of stearoyl-CoA desaturase modulates the hippocampal fatty acid profile and restores density of dendritic spines in the aggressive 5xFAD model of Alzheimer s disease

This study shows that inhibiting SCD improves fatty acid profiles and restores dendritic spine density in a 5xFAD Alzheimer's model.

RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

This study identifies RABGAP1 as a sensor that modulates APP trafficking and processing by regulating RAB activity on endosomal subdomains, with implications for Alzheimer's disease.

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

This paper uses VINE-seq to create a vascular transcriptomic atlas in Alzheimer's disease, revealing transcriptional changes in vascular cells and identifying angiopoietin signaling as a key dysregulated pathway.

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

Decoding Amyloid Plaque Penetrability: Exploring Extracellular Space and Rheology2in Plaque-rich Cortex

This study investigates amyloid plaque penetrability and extracellular space rheology in an AD mouse model using imaging techniques, finding heterogeneous diffusivity and dysregulated extracellular matrix around plaques.