Neuroinflammation and Neurodegeneration Mechanisms

Single cell RNA sequencing reveals immunomodulatory effects of stem cell factor and granulocyte colony-stimulating factor treatment in the brains of aged APP/PS1 mice

This study uses single-cell RNA sequencing to show SCF+G-CSF treatment modulates microglia and myeloid cells in aged APP/PS1 mice, enhancing immune responses and Aβ clearance.

Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions

This study uses human-mouse chimeric brain models to investigate glial-neuronal and macroglial-microglial interactions, revealing key molecular mechanisms and dynamic cellular behaviors.

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer's disease

This study examines how APOE isoforms affect the transcriptomic and epigenomic features of human microglia in an Alzheimer's disease xenotransplantation model, identifying genotype-dependent differences.

Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner

This study investigates how influenza A virus infection during pregnancy affects maternal intestinal immunity and fetal brain development, finding dose-dependent effects without increased IL-17 signaling.

Development of a high-throughput pipeline to characterize microglia morphological states at a single-cell resolution

The paper develops an open-source pipeline to characterize microglia morphology at single-cell resolution using ImageJ and R, identifying distinct morphological states across brain regions and conditions.

Rod-shaped microglia interact with neuronal dendrites to regulate cortical excitability in TDP-43 related neurodegeneration

The paper identifies rod-shaped microglia in a TDP-43 mouse model that interact with neuronal dendrites to reduce cortical hyperexcitability and protect against neurodegeneration.

Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation

This study shows that human-specific SRGAP2B/C paralogs drive neotenic microglia maturation and influence synaptic development in human brains.

Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization

The paper identifies molecular signatures of HERV-W ENV protein effects on microglial and astroglial cells compared to LPS stimulation, linking them to neuroinflammatory processes.

Transgenic Targeting of Fcrls Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity

This paper introduces a constitutively active microglia-specific Cre line, Fcrls-2A-Cre, with high recombination efficiency and specificity, suitable for studies where tamoxifen is not feasible.

Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTK

The paper investigates how microglia remove dying oligodendrocytes, finding that CX3CR1 mediates cell engagement while MERTK is not required for clearance.

Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain

This study identifies microglia as the primary source of TGF-β1 ligand in the adult mouse brain, showing its role in maintaining microglial homeostasis and cognitive function through an autocrine mechanism.

Interaction between mitochondrial translocator protein and aging in inflammatory responses in mouse hippocampus

This study examines how aging interacts with TSPO's immunomodulatory role in mouse hippocampus, showing aging reverses TSPO knockout effects and exacerbates inflammation.

Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

This study shows that type I interferon signaling in microglia contributes to neuroinflammation and aging in the mouse brain.

CHD8 adulthood microglial knockout induces behavioral, morphological, and transcriptional changes in a sex-dependent manner

This study shows that adulthood microglial CHD8 knockout in mice causes sex-dependent behavioral and transcriptional changes, with males showing more pronounced effects.

Microglia replacement effectively attenuates the disease progress of ALSP in the mouse model and human patient

This study shows that microglia replacement through bone marrow transplantation halts disease progression in both mouse models and human patients with ALSP.

Axon length-dependent synapse loss is mediated by neuronal cytokine-induced glial phagocytosis

The paper identifies cytokine signaling from neurons to glia as a key determinant in axon length-dependent vulnerability in fly models of human neurodegenerative disorders.

Role of microglia in stress-induced alcohol intake in female and male mice

This study shows that stress increases alcohol consumption in female mice but not males, and microglial depletion reduces stress-induced drinking in females.

Defective interferon signaling in the circulating monocytes of type 2 diabetic mice

This study identifies altered monocyte subsets and suppressed interferon signaling in T2DM mice, contributing to worsened stroke outcomes through immunosuppression and inflammation.

Microglia contribute to methamphetamine reinforcement and reflect persistent transcriptional and morphological adaptations to the drug

This study shows methamphetamine induces long-term transcriptional and morphological changes in microglia that contribute to drug-seeking behavior and may inform treatment strategies for methamphetamine use disorder.

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites

The paper investigates how primary neurons respond to metabolites linked to type 2 diabetes and Alzheimer's disease, identifying differential secretion of MCP-1 and IL-9.

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease

The paper identifies an expansion of interferon-responsive T cells in early-onset Alzheimer's disease using single-cell RNA-sequencing and ddPCR data.

Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity

The paper shows that Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity, suggesting Hofbauer cells as a noninvasive biomarker for fetal microglial programming.

Applying high-resolution spatial transcriptomics to characterise the amyloid plaque cell niche in Alzheimer's Disease

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.

A microglia-containing cerebral organoid model to study early life immune challenges

This paper introduces a cerebral organoid model with integrated microglia to study how inflammatory stimuli and microglial presence affect neurodevelopment and neurodevelopmental disorders.

Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia

This study shows that Sema4B on astrocytes enhances microglia reactivity via Plexin-B2, contributing to CNS injury outcomes.

Structural and functional analysis of TREM2 interactions with amyloid beta reveal molecular mechanisms that mediate phagocytosis of oligomeric amyloid beta

SHIP1 modulation and proteome characterization of microglia

This study examines the proteomic and transcriptomic effects of SHIP1 modulation in microglia, revealing significant proteomic changes in SHIP1 homozygous knockout and differences between BV2 and HMC3 cell lines.

Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2

This study shows that Neu1 regulates microglial function by modulating Trem2 sialylation, affecting phagocytosis and cytokine production.

Intercellular adhesion molecule-1 reprograms microglia to improve cognitive functions by inhibiting ERK/STAT3 signalling pathway in a model of Alzheimer's disease

This study shows ICAM-1 reduces microglial inflammation and improves cognitive function in Alzheimer's disease by inhibiting the ERK/STAT3 pathway.