Neuroinflammation and Neurodegeneration Mechanisms

Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model

This study shows that macrophage transplantation rescues RNASET2-deficient leukodystrophy in zebrafish by replacing dysfunctional microglia, reducing neuroinflammation and restoring motor function.

Fetal brain response to maternal inflammation requires microglia

This study shows that microglia mediate fetal brain transcriptional responses to maternal inflammation, highlighting their role in neurodevelopmental outcomes.

Excitatory Neuron-Derived Interleukin-34 Controls Cortical Developmental Microglia Function

This study identifies IL34 as a neuron-derived cytokine that regulates microglia maturation and synapse engulfment in the developing mouse cortex.

Viral mimicry and memory deficits upon microglial deletion of ATRX

This study shows that deleting ATRX in microglia disrupts chromatin structure, leading to viral mimicry and cognitive deficits in memory tasks.

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

This study shows that neuronal DAMPs activate astrocytic RIPK3 signaling, leading to neuroinflammation and dopaminergic cell death in Parkinson's disease.

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

This study examines how stroke alters myeloid cell composition and phenotypes in the brain, linking changes to cell origin, spatial organization, and brain connectivity.

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction.

This study examines how high-fat diet and brain trauma interact to alter macrophages in adipose tissue and microglia in the brain, leading to worsened cognitive function.

RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection

This study identifies RIPK3's role in promoting neuronal survival during CNS viral infection by suppressing excitatory neurotransmission, independent of its traditional necroptotic function.

Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking.

This study shows that ACE expression in microglia reduces amyloid β deposition and neurodegeneration by enhancing SYK signaling and endolysosomal trafficking in Alzheimer's disease models.

Microglial MyD88-dependent pathways are regulated in a sex specific manner in the context of HMGB1-induced anxiety

This study investigates HMGB1-induced anxiety in mice, finding sex-specific differences in microglial MyD88-dependent pathways in the medial prefrontal cortex.

Glia-Mediated Antigen Presentation In The Retina During Degeneration

This study investigates glia-mediated antigen presentation in retinal degeneration, revealing distinct roles of microglia and Muller glia in immune responses through MHC pathways and cytokine signaling.

Microglial-Mediated Prevention of Axonal Degeneration in the Injured Spinal Cord: Insights from an In Vivo Imaging Study

This study shows microglia prevent axonal degeneration after spinal cord injury by wrapping injured axons, a process dependent on P2Y12 receptors and sodium channels.

Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis

The paper identifies UDP-P2Y6 signaling as a key driver of microglial calcium activity, phagocytosis, and neuroinflammation during epileptogenesis.

Low-grade systemic inflammation stimulates microglial turnover and accelerates the onset of Alzheimer's-like pathology

This study shows that low-grade systemic inflammation accelerates Alzheimer's-like pathology by promoting microglial turnover and disease-associated microglia through the CSF1R pathway.

Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

This study identifies intermediate microglial states in aging hippocampal tissue that drive inflammation and cognitive decline through single-cell RNA-Seq and genetic models.

Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury

The paper investigates how LPS preconditioning affects microglial proteome response to focal ischemic brain injury in mice, finding significant neuroprotection and changes in proteome patterns linked to type I interferons.

Microglia shape hippocampal networks but are dispensable for pruning of synapses during development

This study shows that microglia are not essential for synaptic pruning during development but influence hippocampal network function in adult mice.

Amyloid precursor protein induces reactive astrogliosis

This study shows APP induces reactive astrogliosis in vitro and in vivo by remodeling intermediate filaments, enhancing cytokine production, and activating the IFN pathway.

Translational control of microglial inflammatory and neurodegenerative responses

This study identifies the mTORC1-4E-BP1 axis as a neuroprotective mechanism in microglia under AD conditions, showing its role in suppressing inflammation and neurodegeneration.

Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity

This study shows that mTORC1 inhibition with rapamycin reduces brain damage and neuronal loss after ischemia by modulating microglial reactivity.

Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism

This study shows that palmitate exposure causes microglia to change their metabolism and release EVs that affect behavior and metabolism in mice.

Dissecting Reactive Astrocyte Responses: Lineage Tracing and Morphology-based Clustering

The paper uses morphology-based clustering and lineage tracing to identify subtypes of reactive astrocytes and their spatial distribution in response to brain damage.

Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging

This study investigates age- and sex-related metabolic changes in female brains and microglia, finding that estrogen may suppress disease-associated microglia (DAM) factors, potentially increasing Alzheimer's disease risk in post-menopausal women.

A multi-pronged human microglia response to Alzheimer's disease Aβ pathology

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

This study shows that ALS-linked PFN1 mutations impair vesicular degradation in iPSC-derived microglia by disrupting autophagy, which can be mitigated by Rapamycin.

Targeting neuroinflammation by pharmacologic down-regulation of inflammatory pathways is neuroprotective in protein misfolding disorders.

This paper shows that targeting neuroinflammation by down-regulating NF-κB and NLRP3 with SB_NI_112 protects against neurodegeneration in prion disease models.

SorLA restricts TNFalpha release from microglia to shape glioma-supportive brain microenvironment

The paper shows SorLA restricts TNFα release from microglia, reducing their anti-tumor response and promoting glioma growth.

An arrayed CRISPR/Cas9 screen identifies mTORC1 as a regulator of lipid droplet accumulation in APOE E3 and APOE KO iPSC-derived microglia

Rat primary cortical cell tri-culture to study effects of amyloid-beta on microglia function

This study uses a rat primary cortical tri-culture model to show that microglia in co-culture with neurons and astrocytes more effectively clear amyloid-beta and exhibit altered motility compared to co-culture or mono-culture.