Neuroinflammation and Neurodegeneration Mechanisms

HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures in vitro

The paper uses HDAC inhibitors to mimic human DAM in vitro and identifies shared marker genes.

Tracking changes in functionality and morphology of repopulated microglia in young and old mice

The paper studies repopulated microglia in young and old mice using scRNA-seq and other methods, finding they originate from progenitors, reconstitute functional clusters, and show increased inflammation and distinct morphology in aging.

The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer's disease progression

This study identifies the PHD3-FOXO3 axis as a regulator of the interferon type I response in microglia, which contributes to Alzheimer's disease progression.

Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation

This study investigates how an obesogenic diet and psychosocial stress during adolescence affect brain health, revealing synergistic impacts on neuroinflammation, gut microbiota, and gene methylation.

Circulatory proteins shape microglia state and boost phagocytosis

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease

This study shows that AIBP regulates TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease, reducing neuroinflammation and neurodegeneration.

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

This study shows that ADF/Cfl1 deficiency in microglia reduces motility and impairs memory by affecting cytoskeleton dynamics.

The glia club: Validation of polarization biomarkers for human microglia (HMC3) using quantitative real time RT-qPCR.

This study validates polarization biomarkers for human microglia (HMC3) using RT-qPCR, providing a comprehensive list of markers and methodology for gene expression analysis.

Microglial adipose triglyceride lipase regulates neuroinflammatory and behavioural responses to LPS

This study shows that inhibiting ATGL in microglia reduces LPS-induced inflammation and sickness behavior in mice.

CX3CR1 modulates migration of resident microglia towards brain injury

This study shows that CX3CR1 deficiency enhances microglial migration towards brain injury, suggesting it as a potential therapeutic target for CNS injuries.

Repeated LPS induces training and tolerance of microglial responses across brain regions

This study shows that repeated LPS exposure induces training and tolerance in microglial responses across brain regions, with distinct gene expression patterns and morphological changes.

Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior

High-fat and high-sucrose diet-induced hypothalamic inflammation shows sex specific features in mice

This study examines sex-specific hypothalamic inflammation in mice fed a high-fat and high-sucrose diet and finds partial recovery after diet normalization.

Monocyte-derived cells but not Microglia cause Oxidative Tissue Damage in Neuroinflammation

The paper identifies monocyte-derived cells as the primary source of ROS-mediated oxidative tissue damage in neuroinflammation, distinct from microglia.

Microglia contact cerebral vasculature through gaps between astrocyte endfeet

The paper investigates microglial interactions with cerebral vasculature using electron microscopy data, finding that 20% of microglia form direct contacts through gaps between astrocyte endfeet.

Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retina

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

CD300f immune receptor is a microglial tissue damage sensor and regulates efferocytosis after brain damage

This study shows that CD300f is a microglial receptor that detects tissue damage and regulates efferocytosis after brain injury.

Decreased Astrocytic CCL5 by MiR-324-5p Ameliorates Ischemic Stroke Injury via the CCR5/ERK/CREB Pathway

This study shows that reducing astrocytic CCL5 via miR-324-5p reduces ischemic stroke damage by enhancing the ERK/CREB pathway in neurons.

Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models

This study identifies astrocyte-derived MFG-E8 as a key mediator of microglial synapse elimination in Alzheimer's disease mouse models, showing its role in synapse loss and potential as a therapeutic target.

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

This study shows IRF3 regulates neuroinflammatory responses and Alzheimer's disease-related gene expression through its effects on microglia and myeloid cells.

Loss of Insulin Signaling in Microglia Impairs Cellular Uptake of Aβ and Neuroinflammatory Response Exacerbating Alzheimer-like Neuropathology

This study shows that loss of insulin signaling in microglia impairs Aβ uptake and neuroinflammatory response, leading to increased Alzheimer-like pathology.

Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locus

The paper maps GWAS variants associated with late-onset Alzheimer's disease to functional effects in microglial cells, identifying RTFDC1 as a novel effector gene at the CASS4 locus.

Inflammatory Signatures of Microglia in the Mouse Model of Corticosterone-Induced Depression

The paper identifies inflammatory microglia signatures in a mouse model of corticosterone-induced depression using bulk and single-cell RNA sequencing.

Epigenetic heterogeneity shapes the transcriptional landscape of regional microglia

This study uses CUT&Tag-Direct to analyze histone modifications in microglia across brain regions, revealing region-specific transcriptional networks and epigenetic signatures.

Turning microglia neuroprotective: Towards connexin43-specific therapy of Alzheimer's disease

This study identifies microglial connexin43 hemichannels as a therapeutic target for Alzheimer's disease, showing that blocking them reduces pathology and cognitive impairment in mouse models.

Transcriptional and Cellular Response of hiPSC-derived Microglia-Neural Progenitor Co-Cultures Exposed to IL-6

The paper investigates how IL-6 exposure affects hiPSC-derived microglia-neural progenitor co-cultures, finding minimal transcriptional response in NPCs despite MGLs secreting IL-6R.

Adenosine triggers early astrocyte reactivity that provokes microglial activation and drives the pathogenesis of sepsis-associated encephalopathy

This study shows that adenosine triggers early astrocyte reactivity in sepsis, leading to microglial activation and SAE pathogenesis.

Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity

This study identifies aberrant astrocytic calcium signaling in MS models as a contributor to synaptic plasticity impairment and gray matter pathology.

Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function.

The paper introduces an organelle phenotyping approach using live-cell microscopy to identify C1q as a regulator of microglial function, showing its role in fatty acid storage and mitochondrial membrane potential.

Morphotype-specific calcium signaling in human microglia

The paper analyzes Ca2+ signaling in human microglia and finds differences in signal properties across morphotypes.