Telomeres, Telomerase, and Senescence

Human telomere length is chromosome specific and conserved across individuals

The paper develops a nanopore sequencing method to measure telomere length and finds chromosome-specific and conserved telomere lengths across individuals.

Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden

The paper profiles miRNA expression during senescence and aging to identify potential circulating biomarkers of senescent cell burden in mice and humans.

Machine learning recognises senescence in glioblastoma and discovers senescence-inducing compounds

The paper uses machine learning to identify senescent glioblastoma cells and discovers compounds that induce senescence in these cells.

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.

This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

The paper identifies natural compounds that mimic dasatinib's senotherapeutic effects using gene expression data, highlighting potential alternatives for senolytic therapy.

AQP1 Differentially Orchestrates Endothelial Cell Senescence

This study identifies AQP1 as a regulator of endothelial cell senescence and angiogenesis, showing its dual role in proliferating and senescent cells through modulation of the HDAC4-Mef2A pathway.

Cross-tissue comparison of telomere length and quality metrics of DNA among individuals aged 8 to 70 years

The paper compares telomere length and DNA quality metrics across five tissues in individuals aged 8 to 70 years, finding age-related shortening in most tissues and tissue-specific variations in DNA quality.

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.

TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

This study identifies TRIM24's role in ALT telomere maintenance through chromatin signaling, showing it promotes telomere DNA synthesis via SUMO-dependent mechanisms.

Unraveling the causal genes and transcriptomic determinants of human telomere length

This study identifies causal genes and transcriptomic factors influencing human telomere length using placental tissue data and GWAS.

Identification of a P62-TIF-IA axis that drives nucleolar fusion and the senescence associated secretory phenotype

This study identifies a p62-TIF-IA axis that drives nucleolar fusion and the senescence-associated secretory phenotype (SASP) through ATM-mediated disruption of autophagic degradation.

Individual cell fate and population dynamics revealed by a mathematical model linking telomere length and replicative senescence

This study develops a mathematical model to link telomere length and replicative senescence in yeast, revealing population dynamics and factors affecting proliferation capacity.

LEF1 isoforms regulate cellular senescence and aging

The paper identifies LEF1 isoforms as key regulators of cellular senescence and aging through transcriptomic analysis and validation in human and mouse models.

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

Single-Cell RNA-Seq Analysis Reveals Four Stages of Replicative Senescence in Human Umbilical Vein Endothelial Cells

The paper analyzes scRNA-Seq data from HUVECs to identify four stages of replicative senescence and characterizes TF expression patterns across these stages.

Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast

This study shows that Pot1 in fission yeast is essential for telomere DNA replication by recruiting the Stn1-Ten1 complex and Pol-primase, preventing ssDNA accumulation and telomere loss.

Sprr1 and miR-130b contribute to the senescence-like phenotype in aging

The paper identifies Sprr1a and miR-130b as modulators of senescence-like phenotype in aging, showing their roles in regulating inflammatory cytokines and cell cycle regulators.

Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

This study shows that cellular senescence promotes progenitor cell expansion during axolotl limb regeneration by creating a pro-proliferative niche and modulating Wnt signaling.

Telomouse - a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

This paper introduces a mouse model with human-length telomeres by modifying RTEL1 and shows its impact on regenerative capacity.

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells

This study shows that Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells by altering Menin's interaction with telomerase components.

Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation

The paper shows Hog1 counteracts oxidative stress in telomerase-negative yeast during replicative senescence, independent of Mec1.

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequences

The paper identifies 53 rare variants and 22 genes associated with telomere length using UK Biobank whole-genome sequences, highlighting their role in clonal haematopoiesis and disease.

Telomerase-independent survival leads to a mosaic of complex subtelomere rearrangements in Chlamydomonas reinhardtii

The paper uses long-read sequencing to study genome rearrangements in telomerase mutants of Chlamydomonas reinhardtii, revealing complex subtelomere dynamics and alternative mechanisms for chromosome stability.

Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions in Saccharomyces cerevisiae

This study shows that deleting subtelomeric X- and Y-elements in yeast does not affect telomere length or silencing, but impacts telomere maintenance when telomerase is inactivated.

Inverse-folding design of yeast telomerase RNA increases activity in vitro

This paper uses inverse RNA folding to design a full-length yeast telomerase RNA with increased in vitro activity but reduced in vivo abundance.

Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal

The study shows that senescence biomarker intensities reflect the duration of cell-cycle withdrawal, suggesting quiescence and senescence are part of a continuum.