Sphingolipid Metabolism and Signaling

Quantitative Dynamic Analysis of de novo Sphingolipid Biosynthesis in Arabidopsis thaliana

The paper uses dynamic modeling to analyze sphingolipid biosynthesis in Arabidopsis, identifying key enzymes critical for homeostasis and cell viability.

Sphingosine-1-phosphate receptor 3 activation promotes sociability and regulates the expression of genes associated with anxiolytic-like behavior

This paper shows that S1PR3 agonists promote sociability and reduce anxiety-like behavior in mice by altering gene expression in the prefrontal cortex.

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors

This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.

Pan-sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of C. elegans

The paper develops a method to profile sphingolipids in C. elegans and identifies the functional roles of specific isozymes in sphingolipid biosynthesis.

Systematic analysis of the sphingomyelin synthase family in C. elegans

The paper systematically analyzes the sphingomyelin synthase family in C. elegans, identifying three SM synthases and one CPE synthase with distinct subcellular distributions.

Selective S1PR1 activation improves brain infarction, neurological outcome, and cerebrovascular endothelial health following experimental ischemic injury

This study shows that selective S1PR1 activation reduces brain infarct volume and improves neurological outcomes in mice after stroke, while also enhancing endothelial cell survival under hypoxic conditions.

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

This study shows that mice lacking CerS2 in oligodendrocytes develop myelin instability, microglial activation, and early lethality due to reduced C22-C24 sphingolipids.

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition

The paper identifies nSMase2 as a critical regulator of developmental EMT by inducing endocytosis to activate Wnt and BMP signaling during neural crest migration.

Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

The paper shows that altered sulfatide-binding by NF155 links glycosphingolipid imbalances to demyelination by affecting membrane protein abundance and axon-myelin contacts.

An intestinal sphingolipid promotes neuronal health across generations

The paper shows that maternal diet-induced intestinal sphingolipid biosynthesis reduces neurodegeneration in offspring across generations in C. elegans.

A type IV Autotaxin inhibitor ameliorates acute liver injury and non-alcoholic steatohepatitis in mice

This study evaluates a type IV ATX inhibitor, Cpd17, showing improved efficacy over a type I inhibitor in reducing liver injury in mouse models of acute liver injury and non-alcoholic steatohepatitis.

FAM57B is a modulator of ceramide synthesis that regulates sphingolipid homeostasis and synaptic composition in the developing brain

This study identifies FAM57B as a regulator of ceramide synthesis and sphingolipid homeostasis in 16pdel Syndrome, linking it to synaptic dysfunction and neurological symptoms.

Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and protection of anaphylaxis

This study shows that Mfsd2b and Spns2 are essential for embryonic vascular development and vascular homeostasis, and their loss leads to severe hemorrhage and anaphylaxis susceptibility.

Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication

This study shows that SphK2 is essential for remyelination after demyelination and myelin maintenance with age, as SphK2 deficiency leads to greater oligodendrocyte loss and thinner myelin.

Regulation of brain aging by neutral sphingomyelinase 2

This study shows that nSMase2 deficiency reduces ceramide and improves cognition in aged mice by mitigating oxidative stress and astrocyte activation.

FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety

This study shows that FTY720 increases baseline HPA axis activity and reduces anxiety- and despair-like behaviors in rats by reducing angiogenesis in the medial prefrontal cortex.

Lysophosphatidic acid (LPA)-antibody (504B3)validation by free-solution assay and interferometry identifies off-target binding

This study validates an anti-LPA antibody (504B3) and finds it binds non-LPA lipids, suggesting potential off-target effects.

Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants

The paper uses computational modeling to predict regulatory roles of ORM proteins in the plant sphingolipid pathway, identifying both repressive and activating effects on key enzymes.

Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis.

This study shows that LPA1 receptor dysregulation in macrophages contributes to MS pathogenesis by promoting inflammation, with implications for therapeutic targeting.

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae

This study shows that serine uptake via Gnp1 is critical for maintaining sphingolipid homeostasis in yeast by linking serine import to sphingolipid biosynthesis.

Sphingosine 1-phosphate activates the MAP3K1-JNK pathway to promote epithelial movement and morphogenesis

This study identifies S1P as a key activator of the MAP3K1-JNK pathway, which drives epithelial cell movement and eyelid morphogenesis in mice.

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

ATX expression from GFAP+ cells is essential for embryonic development

The paper shows that ATX expression from GFAP+ cells is essential for embryonic development and is reactivated in EAE, linking it to chronic inflammation.

Dynamics of sphingolipids and the serine-palmitoyltransferase complex in oligodendrocytes during myelination.

The paper examines sphingolipid synthesis and the serine-palmitoyltransferase (SPT) complex in oligodendrocytes during myelination in postnatal rats, showing changes in SPT subunit levels and sphingolipid composition.

Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress

This paper shows that dihydroceramide desaturase deficiency causes oxidative stress by altering Rac1 membrane localization and activating Rac1-NADPH oxidase in neurons.

Endothelial sphingosine-1-phosphate receptor 1 deficiency exacerbates brain injury and blood brain barrier dysfunction upon subarachnoid hemorrhage in mice.

This study shows that endothelial S1PR1 deficiency worsens brain injury and BBB dysfunction in mice after subarachnoid hemorrhage.

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

This study shows that inhibiting de novo ceramide biosynthesis with L-cycloserine improves aging-related phenotypes in cultured cortical neurons.