Inflammasome and immune disorders

Molecular dynamics simulations reveal the impact of Ser295 phosphorylation on the structure of pyrin domain-containing NOD-like receptor 3

The paper uses molecular dynamics simulations to show that Ser295 phosphorylation in NLRP3 alters its structure, affecting ATPase activity and inflammasome assembly.

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.

This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

Rab11FIP2 controls NLRP3 inflammasome activation through Rab11b

This study shows Rab11-FIP2 and Rab11b regulate NLRP3 inflammasome activation in human macrophages by controlling caspase-1 cleavage, pyroptosis, and NLRP3 translocation to the trans-Golgi network.

The scaffolding and activation of NLRP3 on acidic vesicles depends on their biophysical properties and is independent of intermediate filaments

This study shows NLRP3 inflammasome activation depends on biophysical properties of acidic vesicles, not intermediate filaments, in vimentin knockout macrophages.

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

This study shows RING1 suppresses pyroptosis by ubiquitinating GSDMD, reducing inflammation and pathogen susceptibility in mice.

PDE10A Inhibition Reduces NLRP3 Activation and Pyroptosis in Sepsis and Nerve Injury

This study shows that PDE10A inhibition reduces NLRP3 inflammasome activation and pyroptosis in sepsis and nerve injury models, with potential for clinical application.

Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic Acids

This study shows that BHB and SCCAs inhibit NLRP3 inflammasome activation under acidic conditions, mediated by GPR41/FFAR3, suggesting their potential as anti-inflammatory agents during metabolic stress.

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria

A morphology and secretome map of pyroptosis

The paper characterizes pyroptosis using secretome profiling and morphology analysis, revealing complex connections with apoptosis through machine learning models.

A novel reporter to visualize and quantify endogenous inflammasomes and caspase-1 recruitment

This paper develops a fluorescent reporter to visualize and quantify endogenous inflammasome assembly and caspase-1 recruitment in real-time.

The association of NLRP3 polymorphisms and its downstream interaction in mild cognitive impairment

This study investigates the association between NLRP3 polymorphisms and downstream gene expression and miRNA interactions in mild cognitive impairment.

Lysosome positioning affects NLRP3 inflammasome activation

This study investigates how lysosome positioning affects NLRP3 inflammasome activation in HeLa and macrophage cells, finding that peripheral lysosome positioning enhances inflammasome activation.

Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial Activation

This study identifies caspase-1 as a driver of vascular inflammation and hypoperfusion in intravascular hemolysis, showing its role in endothelial-leukocyte recruitment and microvascular dysfunction.

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules

This study identifies the caspase-11 CARD as a bipartite lipid-binding module that recognizes both self and nonself lipids, enabling the design of an LPS-binding domain.

NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation.

This study identifies NLRP10's role in cleaving oxidized DNA and its impact on senescence and inflammasome activation through interactions with NLRP3.

Distinct mechanisms are employed by T-cell-instructed myeloid cells for IL-1β production in humans and mice.

This study compares T-cell-driven IL-1β production in humans and mice, finding distinct molecular mechanisms involving different signaling pathways and enzymes.

Role of NLRP3 activation in salt sensitive blood pressure regulation, effect of ND-13

This study investigates the effects of ND-13 and MCC950 on blood pressure regulation in high-salt diet mice, showing they prevent hypertension and inflammatory changes.

Bioactive Flavonoid Extract Suppresses NLRP3 Activation and Inflammation in 2D and 3D Lung Models

This study examines how a bioactive flavonoid extract suppresses NLRP3 inflammasome activation and inflammation in both 2D and 3D lung models.

Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis

This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.

BTK-NLRP3-Caspase1 and Gasdermin D-Caspase 11 pathways jointly drive neuroinflammation and functional impairments in a rat model of psychosocial stress

This study identifies that both canonical and non-canonical inflammasome pathways drive neuroinflammation and behavioral impairments in a rat model of psychosocial stress, with combined targeting showing greater efficacy.

Induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors

This study shows that SARS-CoV-2's ORF9b protein activates inflammasomes and caspase-1, and small molecules inhibiting its homodimerization reduce inflammation and restore interferon signaling.

Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death

This study shows GSDMD-mediated ATP release as an early transient danger signal during NLRP3 inflammasome activation, preceding cell death and IL-1β release.

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

This study shows that NLRP6 inflammasome activation in human intestinal epithelial cells occurs due to endolysosomal damage from pathogens or sterile triggers, leading to pyroptosis.

Macrophage Inflammasome Activation Drives Anti-inflammatory Responses via Neutrophil-Derived ASC Speck Transfer and Gasdermin-Dependent Caspase-1 Inhibition

This study shows macrophage inflammasomes drive anti-inflammatory responses by transferring neutrophil-derived ASC specks and inhibiting caspase-1 via Gasdermin E.

ND-13, a DJ-1 derived peptide, as a novel pharmacological approach in the prevention of NLRP3 inflammasome activity in Diabetic Nephropathy

This study investigates ND-13, a DJ-1-derived peptide, showing its ability to reduce NLRP3 inflammasome activity and renal damage in diabetic nephropathy models.

TLR priming licenses NAIP inflammasome activation by immunoevasive ligands

This study shows TLR priming increases NLRC4 expression in murine macrophages, enabling detection of immunoevasive NAIP ligands, while human macrophages lack this response.

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1

This study identifies UBXN1's role in activating the non-canonical inflammasome via unanchored ubiquitin chains, showing its importance in sepsis and inflammasome signaling.

Evolutionary dynamics of pro-inflammatory caspases in primates and rodents

This study examines the evolutionary history of pro-inflammatory caspases in primates and rodents, revealing differences in gene retention, pseudogenization, and positive selection across species.