Neuroinflammation and Neurodegeneration Mechanisms

Context-dependent transcriptional regulation of microglial proliferation

This study identifies transcriptional mechanisms regulating microglial proliferation in development and disease models, revealing two modes of gene regulation.

Single cell profiling of Hofbauer cells and fetal brain microglia reveals shared programs and functions

The paper uses single-cell RNA sequencing to compare fetal brain microglia and Hofbauer cells, revealing shared transcriptional programs and sex-specific differences.

Mitochondrial control of microglial phagocytosis in Alzheimer's disease

This study shows that TSPO regulates mitochondrial metabolism and phagocytosis in microglia, and that targeting mitochondrial HK could improve phagocytosis in Alzheimer's disease.

A new method for obtaining bankable and expandable adult-like microglial cells

This paper develops a method to generate adult-like microglial cells from mouse embryos, showing improved functionality and gene expression compared to neonatal microglia.

Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke

This study shows that repeated HPβCD treatment reduces chronic inflammation and cognitive decline after stroke by modulating lipid metabolism and immune responses.

MGEnrichment: a web application for microglia gene list enrichment analysis

MGEnrichment provides a web tool for analyzing gene expression data against curated microglia gene lists to assess enrichment and relevance in neuro-immunology research.

Lipopolysaccharide-induced neuroinflammation disrupts functional connectivity and community structure in primary cortical microtissues

This study uses 3D cortical microtissues to show that lipopolysaccharide induces functional connectivity changes and disrupts community structure in neural microcircuits.

Ca2+ activity is required for injury-induced migration of microglia

This study shows that intracellular Ca2+ activity is necessary for microglia migration after brain injury in zebrafish.

Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1

This study shows that Iba1 deficiency in mice leads to microglial dysfunction, reduced synaptic development, and behavioral impairments.

Chemical inhibition of pathological reactive astrocytes promotes neural protection

This study shows that inhibiting HDAC3 reduces pathological features of reactive astrocytes in vitro and in vivo, promoting neural protection in neurodegenerative diseases.

Mechanisms underlying microglial colonization of developing neural retina in zebrafish

The paper investigates how microglial precursors colonize the developing neural retina in zebrafish, identifying key factors like CSF receptor signaling, blood vessels, and neurogenesis as guiding cues.

Concerted cellular responses to type I interferon propel memory impairment associated with amyloid β plaques

This study identifies type I interferon signaling as a key driver of memory impairment in Alzheimer's disease by promoting neuroinflammation and synaptic loss in a mouse model.

The loss of enzymatic activity of the PHARC associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation

This study shows that loss of ABHD12 enzymatic activity increases phagocytosis in cerebellar microglia, leading to neuroinflammation in a mouse model of PHARC.

GABAergic neuronal IL-4R mediates T cell effect on memory

The paper shows that IL-4R on GABAergic neurons mediates T cell effects on memory through synaptic plasticity and fear memory.

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

SARS-CoV-2 spike glycoprotein S1 induces neuroinflammation in BV-2 microglia

This study shows that SARS-CoV-2 spike protein S1 induces neuroinflammation in BV-2 microglia through NF-κB and p38 MAPK activation, mediated by TLR4.

Deficiency of p38&α-MAPK in myeloid cells ameliorates symptoms and pathology of APP-transgenic AD mice

This study shows that deleting p38-MAPK in myeloid cells reduces Aβ levels and improves cognitive function in APP-transgenic AD mice.

Microglia control glutamatergic synapses in the adult mouse hippocampus

This study shows that microglia regulate glutamatergic synapses in adult mouse hippocampus, with their removal causing reversible synaptic and behavioral changes.

Rac1 signaling in microglia is essential for synaptic proteome plasticity and experience-dependent cognitive performance

This study shows Rac1 in microglia is crucial for synaptic proteome plasticity and cognitive performance through homeostatic regulation and synapse communication.

Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer's disease progression.

The paper identifies stage-specific microglia subtypes in Alzheimer's disease using single-cell RNA-sequencing, showing both amyloid-beta and tau pathologies are required for their induction.

Synapse development is regulated by microglial THIK-1 K+ channels

This study shows that THIK-1 K+ channels in microglia regulate phagocytosis and synaptic pruning, with loss of THIK-1 increasing synaptic density in the hippocampus.

In situ and transcriptomic identification of synapse-associated microglia in the developing zebrafish brain

The paper identifies distinct microglial subsets in zebrafish brains that perform different phagocytic functions using single-cell RNA sequencing and spatial analysis.

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling.

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.

Intravital imaging of cerebral microinfarct reveals an astrocyte reaction led to glial scar

The paper uses intravital imaging to study cellular changes after cerebral microinfarction in mice, finding that astrocyte reactivity leads to glial scar formation.

A preclinical randomized multicenter trial of anti-IL-17A treatment for acute ischemic stroke

This paper reports a preclinical randomized trial showing that anti-IL-17A treatment reduces infarct volume in a mouse stroke model.

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles

The paper uses single-cell and nucleus RNA-seq to analyze glial subpopulations in AD mouse models, finding differences in astrocyte activation and microglia subtypes between 3xTg-AD and 5xFAD models.

TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

This study shows that TNF-mediated necroptosis, not apoptosis, contributes to neuronal loss in Alzheimer's disease and is a potential therapeutic target.

SFRP1 shapes astrocyte to microglia cross-talk in acute and chronic neuroinflammation

This study shows that SFRP1 from astrocytes promotes microglial activation in acute and chronic neuroinflammation, suggesting it as a therapeutic target.

Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative disease

This study shows genetically engineered microglia-like cells can provide therapeutic protein levels in mouse models of neurodegenerative diseases.

The secretome of M1 and M2 microglia differently regulate proliferation, differentiation and survival of adult neural stem/progenitor cell

This study shows that M1 and M2 microglia secretomes differentially regulate adult NSPC proliferation, differentiation, and survival through conditioned medium effects.