Neuroinflammation and Neurodegeneration Mechanisms

Microglial amyloid beta clearance is driven by PIEZO1 channels

This study shows that activating PIEZO1 channels in microglia improves amyloid beta clearance in AD models by enhancing survival, phagocytosis, and lysosomal activity.

Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences in male mice

This study shows that blocking P2Y12 in microglia prevents stress-induced synapse loss and behavioral deficits in male mice.

Differences in microglia morphological profiles reflect divergent emotional temperaments: Insights from a selective breeding model

The paper investigates how microglia morphology differs between rat lines with distinct emotional temperaments and links these differences to baseline microglial reactivity.

Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

This study identifies Trx80 as a neuron-derived peptide that modulates microglia interferon response via Trem2-dependent mechanisms in Alzheimer's disease models.

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease

The paper analyzes the co-expression patterns of Iba1, TMEM119, and P2RY12 in microglia from Alzheimer's patients and controls, finding differences in marker combinations associated with disease pathology.

Early neuroadaptations to an obesogenic diet identify the schizophrenia-related ErbB4 receptor in obesity-induced hippocampal abnormalities

This study shows that an obesogenic diet affects hippocampal structure and function in rats, with NRG1 administration altering these effects through the TACE/ADAM17-NRG1-ErbB4 signaling pathway.

Atmospheric particulate matter aggravates CNS demyelination via TLR-4/NF-κB-mediated microglia pathogenic activities

This study shows that atmospheric particulate matter worsens CNS demyelination by activating TLR-4/NF-κB signaling in microglia, leading to neuroinflammation and myelin injury.

Efficacy and sex differences in the effects on rat brain microglia of the colony-stimulating factor 1 receptor inhibitor-PLX5622

This study examines the efficacy of PLX5622 in eliminating microglia in adult rat brains, finding significant sex differences in its effectiveness across brain regions.

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.

Granulocyte Colony Stimulating Factor causes cerebellar deficits and anxiety in a mouse model of CSF-1 receptor-related leukoencephalopathy

This study shows that reducing Csf3 in Csf1r+/- mice improves anxiety, motor coordination, and social interaction but not cognitive deficits, and reduces microglial activation in the cerebellum.

Microglial TNFα controls GABAAR plasticity, sleep slow waves and memory consolidation

The paper shows microglial TNFα regulates GABAAR plasticity, sleep slow waves, and memory consolidation through purinergic signaling.

Modulating neutrophils leads to changes in CNS output

This study shows that neutrophils in the meninges affect cognitive and social behaviors in mice, and their depletion triggers compensatory proliferation in response to specific stimuli.

A novel histone deacetylase inhibitor-based approach to eliminate microglia and retain astrocyte properties in glial cell culture.

This paper introduces a method to eliminate microglia in glial cultures without affecting astrocytes using TSA, enabling the study of their distinct roles in immune responses.

Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques

The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.

MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

The paper uses microPET imaging to show that gp120 transgenic mice exhibit heightened neuroinflammation in response to LPS compared to wildtype mice, mirroring HIV-related hypersensitivity in PLWH.

Complement facilitates developmental microglial pruning of astrocyte and vascular networks

This study shows that microglial complement signaling regulates astrocyte pruning and vascular development in the retina.

MicrogliaST: a web server for microglia spatiotemportal pattern analysis in normal and disordered brains

MicrogliaST is a web server that analyzes spatiotemporal patterns of microglia in normal and disordered brains using single-cell transcriptomic data.

Concomitant AD and DLB pathologies shape subfield microglia responses in the hippocampus

This study examines how Alzheimer's and Dementia with Lewy Bodies pathologies influence microglia responses in hippocampal subfields, finding distinct patterns in disease severity and microglial morphology.

Microglia control cerebral blood flow and neurovascular coupling via P2Y12R-mediated actions

This study identifies microglia as key regulators of cerebral blood flow and neurovascular coupling through P2Y12R-mediated mechanisms in mice and humans.

Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies

The paper analyzes the transcriptome of human microglia across brain regions, aging, and disease to identify genetic effects on gene expression and splicing, linking them to neurological disorders.

Comparing the potential of microglia preparations generated using different human iPSC-based differentiation methods to model microglia-mediated mechanisms of amyotrophic lateral sclerosis pathophysiology

This study compares transcriptomes of human iPSC-derived microglia generated by different methods to assess their ability to model microglia heterogeneity in ALS.

Single-cell analysis of microglial transcriptomic diversity in subarachnoid hemorrhage

The paper uses single-cell RNA sequencing to analyze microglial transcriptomic diversity in subarachnoid hemorrhage, identifying distinct subgroups and their roles in neuroinflammation.

Prenatal immune stress induces a prolonged blunting of microglia activation that impacts striatal connectivity

This study shows that prenatal immune stress leads to long-term reduced microglia activation, affecting striatal connectivity and neuronal function.

Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimers Disease

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.

Reactive astrocytes prevent maladaptive plasticity after ischemic stroke

This study shows that reactive astrocytes are necessary for promoting beneficial plasticity after ischemic stroke in mice, as their absence leads to impaired recovery and maladaptive connectivity changes.

A neuron, microglia, and astrocyte triple coculture model to study Alzheimer disease

The paper develops a triple co-culture model of neurons, microglia, and astrocytes to study Alzheimer's disease, showing reduced inflammation and synaptic loss in response to Aβ.

Transcriptomic and functional analysis of Aβ1-42 oligomer-stimulated human monocyte-derived microglia-like cells

This study examines the transcriptomic response of human monocyte-derived microglia-like cells to Aβ1-42 oligomers, finding increased metallothionein expression and no inflammatory or HAM/DAM profiles.