Chromatin Remodeling and Cancer

CRISPR-ChIP delineates a Menin-dependent oncogenic DOT1L complex in MLL-leukaemia

The paper introduces CRISPR-ChIP to identify chromatin factors associated with histone modifications in MLL-leukaemia, revealing distinct DOT1L complexes with oncogenic and endogenous functions.

Global Identification of Direct SWI/SNF Targets Reveals Compensation by EP400

The paper identifies direct SWI/SNF targets and reveals EP400 as a compensatory remodeler, showing synthetic lethality in cancer and predicting SWI/SNF dependence from chromatin state.

Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

Structure of nucleosome-bound human PBAF complex

The paper determines the structure of the human PBAF complex bound to an acetylated nucleosome, revealing its modular organization and binding domains.

ASCL1 interacts with the mSWI/SNF at distal regulatory elements to regulate neural differentiation

This study shows ASCL1 interacts with mSWI/SNF complexes to regulate chromatin structure and gene expression during human neurogenesis.

ARID1A maintains transcriptionally repressive H3.3 associated with CHD4-ZMYND8 chromatin interactions

This study shows ARID1A maintains repressive H3.3 chromatin through interactions with CHD4 and ZMYND8, suppressing genes involved in cell motility and epithelial-to-mesenchymal transition in endometriotic cells.

An RNA binding module of SWI/SNF is required for activation of cell-type specific enhancers and super-enhancers in early development

This study identifies an RNA binding module in the SWI/SNF complex that is essential for enhancer activation and cell-type specific gene regulation during early development.

Disruption of Smarce1, a component of the SWI/SNF chromatin remodeling complex, decreases nucleosome stability in mouse embryonic stem cells and impairs differentiation

This study shows that disrupting Smarce1 in mouse embryonic stem cells reduces nucleosome stability and impairs differentiation by altering chromatin structure.

IPMK physically binds to the SWI/SNF complex and modulates BRG1 occupancy

The paper shows IPMK binds to the SWI/SNF complex, regulates BRG1 localization, and affects chromatin accessibility in mouse embryonic stem cells.

SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress

This study shows that SWI/SNF chromatin remodelers are essential for behavioral and transcriptional adaptations to stress and cocaine, with gene inactivation leading to resilience and reduced gene expression.

The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo

The paper shows that BAF and PBAF SWI/SNF complexes differentially regulate cell cycle arrest and invasion in C. elegans anchor cells.

Thyroid Hormone Dependent Transcriptional Programming by TRβ Requires SWI/SNF Chromatin Remodelers

The paper identifies three distinct modes of TRβ interaction with chromatin and shows differential recruitment of SWI/SNF complexes in response to thyroid hormone.

BRG1 defines a genomic subset of inflammatory genes transcriptionally controlled by the glucocorticoid receptor

The paper identifies BRG1 as a key component of a co-repressor complex that GR uses to repress inflammatory genes in macrophages, revealing a non-classical role for the SWI/SNF complex.

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

This study shows that failure to switch from ARID1A-BAF to ARID1B-BAF in patient-derived cells impairs neural crest formation in Coffin-Siris syndrome.

Increased ACTL6A Occupancy Within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell Carcinoma

This study shows that increased ACTL6A occupancy in BAF chromatin remodelers drives SCC initiation by enhancing TEAD-YAP binding and counteracting polycomb repression.

Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia

The paper develops an automated CUT&Tag method to profile chromatin occupancy of KMT2A fusion proteins in leukemia samples, revealing epigenomic heterogeneity and therapeutic sensitivity.

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation

This study shows that bromodomains in BRG1 and BRM promote chromatin binding and are essential for skeletal muscle differentiation by regulating gene expression and cell cycle exit.

Neuronal Activity-Induced BRG1 Phosphorylation Regulates Enhancer Activation

This study shows that BRG1 phosphorylation, induced by neuronal activity, regulates enhancer activation and gene induction, affecting behavior and stress responses in mice.

mSWI/SNF promotes polycomb repression both directly and through genome-wide redistribution

This study shows that the BAF complex both antagonizes and promotes polycomb-mediated repression by redistributing polycomb complexes across the genome in embryonic stem cells.

Altering mammalian transcription networking with ADAADi: An inhibitor of ATP-dependent chromatin remodeling

This paper introduces ADAADi, an inhibitor of ATP-dependent chromatin remodeling, showing anti-tumor effects by altering transcriptional networks and inducing apoptosis.

Chromatin accessibility changes induced by the microbial metabolite butyrate reveal possible mechanisms of anti-cancer effects

This study shows butyrate induces chromatin accessibility changes in colon cancer cells, linking these changes to GWAS loci and somatic mutations in colorectal cancer.

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissue

This study shows that SMARCA4 regulates spatially restricted metabolic changes in 3D multicellular tissues by altering DNA accessibility and gene expression.

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

This study shows BAF and MLL4 work together to activate cell type-specific enhancers during adipogenesis, with BAF being essential for differentiation while PBAF is not.

The Drosophila SWI/SNF chromatin-remodeling complexes BAP and PBAP play separate roles in regulating growth and cell fate during regeneration

This study identifies distinct roles of SWI/SNF chromatin-remodeling complexes PBAP and BAP in regulating regenerative growth and cell fate during Drosophila wing disc regeneration.

Structural insights into assembly and function of the RSC chromatin remodeling complex

This study reveals structural insights into the RSC chromatin remodeling complex by showing how ARP binding induces conformational changes and enhances nucleosome remodeling.

BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells

This study shows BRG1 promotes proliferation in prostate cancer by regulating gene expression related to cell cycle and DNA replication, independent of AR and FOXA1.

Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo

This study shows that SWI/SNF BAF complex dosage regulates cell proliferation and differentiation in C. elegans, with high levels inhibiting division and low levels promoting it.

Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome

The paper determines the structure of the yeast RSC chromatin remodeller bound to a nucleosome, revealing mechanisms of nucleosome sliding and implications for human SWI/SNF complexes and cancer.

The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex

The paper shows that switching from npBAF to nBAF chromatin complexes controls cell cycle exit and promotes neural differentiation in developing mouse brains.