Inflammasome and immune disorders

Cardiomyocytes execute pro- and anti-inflammatory signaling of IFNγ-induced GBP5 by differential regulation of the inflammasome

This study shows cardiomyocytes use GBP5 to regulate both pro- and anti-inflammatory responses to IFNγ through the AIM2/CASP1 pathway and GBP5/TGFβ axis.

NLRP3 acts as a direct sensor of intracellular potassium ions

This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.

Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1α

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation

This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

Hijacking of inflammasome responses by the complement system during Pseudomonas aeruginosa-Aspergillus fumigatus sur-infection

This study identifies a complement-inflammasome signaling axis that drives excessive inflammation during Pseudomonas aeruginosa and Aspergillus fumigatus co-infection in cystic fibrosis patients.

Differential targeting of human pyroptotic Caspase-5 and Caspase-4 by Shigella OspC2 and OspC3

This paper identifies OspC2 and OspC3 as Shigella effectors that specifically target Caspase-5 and Caspase-4, respectively, through their PCS domains, revealing evolutionary adaptations in host and pathogen interactions.

RIPK3-RNASE1 axis as a potential therapeutic and clinical monitoring target in VEXAS syndrome

This study identifies the RIPK3-RNASE1 axis as a potential biomarker and therapeutic target in VEXAS syndrome by linking genetic mutations to disease activity and pathological features.

Gasdermin E is Dispensable for H1N1 Influenza Virus Pathogenesis in Mice

This study shows that gasdermin E is not essential for H1N1 influenza virus pathogenesis in mice, as Gsdme-/- mice exhibit similar infection outcomes to wild-type mice.

NLRP11 promotes non-canonical inflammasome activation in human macrophages by enhancing caspase-4 recognition of cytosolic lipopolysaccharide

This study identifies NLRP11 as a primate-specific factor that enhances CASP4-mediated cLPS detection and non-canonical inflammasome activation in human macrophages.

Dickkopf1 is a Novel Endogenous Ligand for priming NLRP3 Inflammasome in Macrophages via TLR4

This study identifies DKK1 as a novel endogenous ligand that primes macrophages via TLR4 to activate NLRP3 inflammasome and induce pyroptosis, distinct from LPS signaling.

Human NLRP1 and NLRP3 interact driving inflammation in inflammosomopathies and inflammatory diseases

This study identifies a hybrid inflammasome formed by NLRP1 and NLRP3 in human cells, associated with inflammation in inflammasomopathies and transplant patients.

A TAK1-Driven NLRP1 Inflammasome Pathway Revealed by Phosphatase-Targeting Environmental Toxins

The paper identifies PP1 and PP2A phosphatases as regulators of NLRP1 inflammasome activation, showing that environmental toxins and viral infections trigger this pathway via TAK1 and p38 kinases.

TAK1 integrates the NLRP1 inflammasome into the innate immune response to double-stranded RNA

This study shows TAK1 activates the NLRP1 inflammasome in response to dsRNA, linking it to inflammatory responses in viral infection and autoimmunity.

Two orthogonal MAP3K-driven pathways of NLRP1 inflammasome activation revealed by poisonous beetles.

This paper identifies two distinct MAP3K pathways activated by beetle toxins that trigger NLRP1 inflammasome activation in human keratinocytes.

Pore-size dynamics control complex volume swelling in pyroptosis.

This study shows that pore-size dynamics in pyroptosis control cell swelling through GSDMD and Ninj1, with distinct permeability regimes affecting ion selectivity and water filtration.

Local albumin excess exacerbates Candida albicans-induced inflammasome activation underlying the immunopathology of vulvovaginal candidiasis.

This study shows that local albumin excess in the vagina exacerbates Candida albicans-induced inflammasome activation, contributing to hyperinflammation in vulvovaginal candidiasis.

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome

This study identifies OspF as a Shigella effector that inhibits NAIP-NLRC4 inflammasome activation by blocking p38-dependent priming, explaining human susceptibility to Shigella.

Lipid droplet accumulation drives glutamine-dependent NLRP3 inflammasome activation

This study shows that lipid droplet accumulation promotes NLRP3 inflammasome activation through glutamine-dependent metabolic reprogramming in macrophages.

Dual NLRC4 and non-canonical inflammasome signaling drives human GSDMD-mediated killing of Shigella flexneri independently of bacterial cardiolipin.

This study shows that human macrophages use both NLRC4 and non-canonical inflammasome pathways to kill Shigella flexneri without causing cell death, independent of bacterial cardiolipin.

Salmonella SPI2 evades detection by NAIP/NLRC4 despite utilization of a detectable needle

This study shows Salmonella SPI2 evades NAIP/NLRC4 detection by limiting SsaG expression, despite SsaG being detectable when artificially delivered.

NLRP3 Inflammasome Exhibits Context-Dependent Roles in Glioblastoma-Astrocyte Crosstalk

This study investigates NLRP3 inflammasome's context-dependent roles in GBM-astrocyte interactions, showing its dual effects on tumor and astrocyte behavior.

Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson disease

This study shows that LRRK2-G2019S mutation in microglia increases nuclear ASC speck formation, indicating a primed inflammasome state linked to chronic neuroinflammation in Parkinson's disease.

The phosphate exporter XPR1 regulates a gasdermin D-independent mature IL-1β secretion pathway in LPS-stimulated human monocytic cells

This study identifies XPR1 as a regulator of GSDMD-independent IL-1β secretion in human monocytic cells, linking it to phosphate export and revealing a novel pathway for cytokine release.

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation

The paper shows that LPS-induced pyroptosis in bone marrow promotes periosteal bone formation by releasing factors that stimulate osteogenic differentiation of skeletal stem cells.

RM1mAb avoids Intracellular degradation to Synergistically inhibit NLRP3 Inflammasome Activation in Familial Cold Autoinflammatory Syndrome

RM1mAb and TH5487 synergistically inhibit inflammasome activation in human FCAS PBMCs by preventing NLRP3-mtDNA interaction and avoiding lysosomal degradation.

C-terminal lysine residues localise NLRP10 at lipid compartments and govern NLRP10 oligomer formation

This study identifies the C-terminal lysine residues of NLRP10 as critical for its localization to lipid compartments and oligomer formation, highlighting unique activation mechanisms compared to other NLRPs.

TNF-α-Driven Systemic Inflammasome Hyperactivity Links Psoriatic Inflammation to monocyte inflammatory response and platelet activation

This study shows that active psoriasis increases systemic inflammasome activity and monocyte-platelet aggregation, which are reduced by anti-TNF therapy.

NLRP1 Shapes Immune and Inflammatory Signatures in Human Melanoma but Not in Mouse Models

This study shows NLRP1 improves prognosis in human melanoma but not in mouse models, and highlights its potential as a prognostic biomarker and therapeutic target.