T-cell and B-cell Immunology

Combined deletion of ZFP36L1 and ZFP36L2 drives superior cytokine production in T cells at the cost of cell fitness

This study shows that deleting both ZFP36L1 and ZFP36L2 in T cells greatly increases cytokine production but reduces cell viability and signaling.

FOXP3+ Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza Infection

This study shows that FOXP3+ Treg cells use TBET to control activated CD8+ T cells during influenza recovery, but not Trm cell generation.

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection

Interferonγ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

Compartment size and proliferation shape the murine T cell receptor repertoire in splenic T- and B cell zones during an immune response

This study shows that compartment size and proliferation, rather than TCR sequence features, shape the TCR repertoire distribution in splenic T- and B cell zones during immune responses.

Development of ferret immune repertoire reference resources and single-cell-based high-throughput profiling assays

The paper develops ferret immune repertoire reference resources and assays using long-read transcriptome sequencing and genome annotation.

Statistical analysis of repertoire data demonstrates the influence of microhomology in V(D)J recombination

The paper uses statistical analysis of TCR repertoire data to show microhomology influences V(D)J recombination outcomes in humans.

ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

Immune-profiling of T helper 1 (Th1), Th2 and Th17 signatures in murine splenocytes by targeting intracellular cytokines

The paper develops a 17-parameter spectral flow cytometry panel to profile Th1, Th2, and Th17 cytokine signatures in murine splenocytes under steady-state and stimulated conditions.

Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens.

This study compares neonatal and adult MR1T cells, finding neonatal cells have diverse TCR usage, reduced cytotoxicity, and limited pathogen recognition.

Claudin 1-mediated positioning of DC1 to mTECs is essential for antigen transfer-coupled DC1 maturation and maintenance of central tolerance

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

Single-Cell Analysis Reveals Tissue-Specific T Cell Adaptation and Clonal Distribution Across the Human Gut-Liver-Blood Axis

The paper tracks T cell clones across gut, liver, and blood using single-cell RNA and TCR sequencing, revealing tissue-specific adaptations and limited overlap between colonic IELs and lamina propria T cells.

Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors

A single amino acid substitution in CD28 enhances signaling, leading to increased CD8 activation and Tpex generation during viral infection, while accelerating exhaustion in chronic infection.

DNA-PKcs governs LAT-dependent signaling in CD4+ and CD8+ T cells

This study shows DNA-PKcs interacts with LAT at the immune synapse, phosphorylates specific serines, and is essential for T cell function in tumor control and graft rejection.

The epigenetic reader MORC3 is required for T cell development in the thymus

This study shows that MORC3 is essential for T cell development in the thymus, as its loss causes developmental arrest and altered chromatin accessibility in DN1 cells.

Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition

The paper examines molecular and cellular changes in thymic stromal and hematopoietic cells during the perinatal to juvenile transition in mice and humans, identifying key pathways and signaling changes.

Spermidine/spermine N1-acetyltransferase controls tissue-specific regulatory T cell function in chronic inflammation

The paper identifies SAT1 as a marker of skin-specific Treg dysfunction in TH17-mediated inflammation and shows targeting SSAT can rescue Treg function in a mouse model.

Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells

This study shows that IL-7 and IL-15 collaborate to support memory CD8+ T cells, with IL-7R required for self-renewal and IL-15 imposing dependence on IL-7R.

Activated Notch1 Redirects CD4-Fated CD4+ CD8+ Precursors to the CD8 Lineage During Thymocyte Selection Without Causing T Cell Leukemia

Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

Single-cell multiomics reveals the distinct properties of neonatal and adult recent thymic emigrants

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

Maintenance DNA methylation is required for induced regulatory T cell reparative function following viral pneumonia

This study shows that DNA methylation via UHRF1 is essential for iTregs to promote lung recovery after viral pneumonia.

Basic-Leucine-Zipper Transcription Factors Regulate Selective Molecular Phenotypes in Regulatory T Cells During IL-2-Induced Activation

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

The geometry of pMHC-coated nanoparticles and T cell receptor clusters governs the sensitivity-specificity trade-off in T cell response.

This study uses Monte Carlo simulations to show that TCR clustering and NP geometry affect the sensitivity-specificity trade-off in T cell responses to pMHC-coated nanoparticles.

A temporary challenge by tumor cells can lead to a permanent partial-impairment of memory CD8 T cell function

This study compares memory CD8 T cells generated from tumor rejection and acute viral infection, finding that tumor-induced cells show persistent functional defects similar to exhaustion.

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

SeQuoIA: a single-cell BCR sequencing analysis pipeline for tracking selection mechanisms in germinal centres

SeQuoIA is a single-cell BCR sequencing pipeline that tracks selection mechanisms in germinal centres by inferring BCR-driven selection pressure from somatic mutation patterns.

Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade

This study shows that exhausted T cells can form functional memory T cells after antigen clearance, and checkpoint blockade expands these memory clones.