Alzheimer's disease research and treatments

Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

Decoupling Phase Separation and Fibrillization Preserves Activity of Biomolecular Condensates

This study shows that L-arginine prevents Tau condensates from turning into amyloid fibrils without affecting phase separation, preserving their function.

Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation

This study identifies distinct tau filament structures in FTLD-tau caused by the MAPT S305I mutation, revealing a unique 4-layer architecture and potential RNA-like polyanion binding.

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

Ultrasensitive saliva-based detection of early Alzheimer's disease biomarkers via nanoparticle-enhanced evanescent scattering microscopy

This paper develops a saliva-based diagnostic platform using nanoparticle-enhanced TIRS microscopy to detect early Alzheimer's disease biomarkers with high sensitivity and accuracy.

TAX1BP1 recruitment reactivates autophagy of Tau aggregates through ULK1 and TBK1

This study shows that TAX1BP1 recruitment to Tau aggregates reactivates autophagy through ULK1 and TBK1, enabling their clearance in neurodegenerative diseases.

Metformin promotes broad neuroprotection and proteostatic resilience via rngo/DDI2 stabilisation

This paper shows metformin protects neurons by stabilizing rngo/DDI2, enhancing proteostasis and reducing toxicity in multiple neurodegenerative models.

Exploring the PLD1-tau interaction in Frontotemporal Dementia.

This study investigates the role of PLD1 in tau pathology and synaptic dysfunction in FTD using postmortem brain samples and proteomic analyses.

Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology

This study shows cPLA2 overactivation is linked to synaptic loss and cognitive decline in Alzheimer's disease through increased eicosanoids and altered synaptic marker interactions.

Correlations of 276 missense variants of PSEN1, PSEN2, and APP on the production of Aβ peptides against variant effect predictors and biophysical structures

This study correlates 276 missense variants in PSEN1, PSEN2, and APP with Aβ peptide levels and variant effect predictors to assess pathogenicity in early-onset Alzheimer's disease.

Silencer variants are key drivers of gene upregulation in Alzheimer's disease.

This paper identifies silencer variants as key drivers of gene upregulation in Alzheimer's disease using a deep learning framework combining bulk and single-cell epigenomic data.

Intravenous anti-abeta immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 mice

This study shows that anti-Aβ immunotherapy in APOE4 mice increases cerebral amyloid angiopathy and vascular damage, while APOE3 mice show no significant changes.

Amyloid β instigates cardiac neurotrophic signaling impairment, driving Alzheimer's associated heart disease.

This study identifies Aβ-induced cardiac neurotrophic signaling impairment in AD models and human tissue, linking AD pathology to cardiac dysfunction.

Multi-scale transcriptomic integration reveals cell-type immune networks and lncRNA remodeling in Alzheimers disease

This study integrates bulk and single-cell transcriptomics with network modeling to reveal immune networks and lncRNA remodeling in Alzheimer's disease across brain regions.

Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

This study characterizes the binding and modification requirements of 20 anti-Aβ antibodies across different Aβ forms, revealing aggregation-dependent sequence and modification selectivity.

Preferential generation of pathological tau species in specific subtypes of entorhinal neurons: implications for Alzheimer's Disease.

The paper investigates differential susceptibility of entorhinal neuronal subtypes to pathological tau species in Alzheimer's Disease, finding that ECLIII neurons show greater vulnerability than ECLII fan cells.

Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD Mice

This study identifies early synaptic and metabolic dysfunctions in 5xFAD mice before plaque formation, linking them to hippocampal vulnerability in Alzheimer's disease.

Spatial memory in Alzheimer's disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330

This study shows that XPO1 inhibitor KPT-330 improves spatial memory in Alzheimer's 5XFAD mice by reducing amyloid deposition in specific brain regions while increasing overall amyloid levels.

Expression of the human immunomodulatory protein, human B7-1 (CD80), accelerates neuroinflammation, synaptic loss, microvascular instability and lethality in a murine model of Alzheimers Disease

This study shows that expressing human B7-1 in mice accelerates AD-like symptoms by enhancing neuroinflammation and synaptic loss.

Synergistic retinal UCHL1 dysregulation and synaptic vulnerability reflect Alzheimer's disease severity

The paper identifies UCHL1 dysregulation and synaptic loss in the retina as markers of Alzheimer's disease severity using integrated multi-omics analysis.

ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer's disease mice -- a new pharmacological target for Glu-related neurotoxicity

This paper investigates how ABCA7 deficiency worsens glutamate excitotoxicity in Alzheimer's disease mice, identifying ABCA7 as a potential pharmacological target for Glu-related neurotoxicity.

Cell type-resolved proteomics reveals intra- and intercellular signalingin Alzheimers disease

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

APP metabolism is regulated by p97/VCP through an autophagy and endolysosome-dependent mechanism

This study shows that p97/VCP regulates APP metabolism by controlling its trafficking and autophagy-dependent degradation of APP-CTFs, linking it to Alzheimer's disease pathology.

An in vivo model of Amyloid-Related Imaging Abnormalities (ARIA) predicts ARIA incidence of anti-Aβ antibodies seen in clinical trials

The paper uses a mouse model to study ARIA induced by anti-Aβ antibodies, showing MRI and histopathologic features similar to human ARIA.

Ketone body beta-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

Is SORL1 a common genetic target across neurodegenerative diseases?: A multi-ancestry biobank scale assessment

This study investigates the role of SORL1 genetic variants in AD, RD, and PD across diverse populations, identifying variants associated with risk but no significant cumulative effect.

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimers disease

The paper identifies reduced triacylglycerols and lipid droplets in resilient Alzheimer's donors compared to AD patients, using multi-omics analysis of brain tissue.