Alzheimer's disease research and treatments

The biochemical nature of senile plaques: intracellular destabilized-lysosome-enriched neural processes catabolizing extracellular hemorrhagic amyloid materials

This study investigates senile plaque formation in Alzheimer's disease using immunohistochemistry and fluorescence imaging, finding that Aβ deposition occurs in degenerative neuritic processes with lysosome destabilization and hemorrhage-related markers.

Traumatic brain injury exacerbates mitochondrial dysfunction in APP/PS1 knock-in mice through time-dependent pathways

This study shows that traumatic brain injury worsens mitochondrial dysfunction in APP/PS1 mice through time-dependent mechanisms, with sex differences in vulnerability.

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-G-F Knock in Mouse Model

This study identifies epigenetic and transcriptomic changes in the hippocampus and blood of an Alzheimer's mouse model before amyloidosis onset, suggesting blood methylation as a potential biomarker.

FAM84B facilitates tau propagation via RYR3-mediated exocytosis in response to neuroinflammation

This study identifies FAM84B as a novel protein facilitating tau propagation through RYR3-mediated exocytosis in response to neuroinflammation.

Identification of common variants influencing risk of the three-repeat tauopathy Pick's disease: a genome wide association study.

This study conducts a GWAS on Pick's disease and identifies two SNPs associated with risk, though not at genome-wide significance, suggesting potential genetic factors beyond MAPT mutations.

Kv1.3 inhibition alleviates neuropathology via neuroinflammatory and resilience pathways in a mouse model of Aβ pathology

This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.

p21-activated kinase regulates Rab3a vesicles to repair plasma membrane damage caused by Amyloid-β oligomers

This study shows that p21-activated kinase (PAK1) and Rab3a work together to repair plasma membrane damage caused by Aβ oligomers in neuronal cells.

A Global Thermodynamic-Kinetic Model Capturing the Hallmarks of Liquid-Liquid Phase Separation and Amyloid Aggregation

This paper develops a thermodynamic-kinetic model that integrates liquid-liquid phase separation with amyloid aggregation to resolve conflicting effects of LLPS on fibrillization.

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer's disease

This paper identifies Sarm1 as a driver of synapse degeneration and memory loss in Alzheimer's disease by showing its deletion prevents synapse loss and cognitive decline in mouse models.

Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer's disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

This study infects 5xFAD mice with SARS-CoV-2 and finds no change in Alzheimer's pathology but widespread gene expression changes in multiple cell types.

Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril Core

This paper investigates how aducanumab binds to Aβ1-42 fibrils, showing it preserves the fibril core structure while altering N-terminal dynamics and reducing secondary nucleation.

Oxidized MIF is an Alzheimer's Disease drug target relaying external risk factors to tau pathology

The paper identifies oxidized MIF as a drug target that links HSV-1 infection and external stressors to tau pathology in Alzheimer's disease.

Trem2*R47H and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice

This study compares two mouse models of TREM2 variants, showing both mimic Alzheimer's disease signatures in similar biological domains.

High-density lipoprotein mimetic peptide 4F ameliorates APOE4-associated lipid dysfunction in primary and iPSC-derived astrocytes and cerebral organoids

This study shows that the HDL-mimetic peptide 4F improves APOE secretion and lipidation in E4 astrocytes and organoids, reducing A{beta}42-induced dysfunction.

STING_IFN_CH25H lipid axis links innate immune activation to tau pathology

The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

Dietary Interventions Modulate Cell Competition and Locomotor Decline in an Alzheimer's Disease Drosophila Model

This study shows that dietary interventions affect cell competition and locomotion in a Drosophila Alzheimer's model, with synthetic diets delaying disease progression.

Alzheimer disease risk variant rs11218343 determines functional expression of SORL1 in microglia

This paper shows that rs11218343 affects SORL1 expression in microglia, with increased expression linked to reduced inflammation, but the variant itself is not directly functional.

Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk

The paper identifies EGFR as a potential therapeutic target in Alzheimer's disease by linking a risk variant to increased EGFR expression in brain cell types through genomic analysis and CRISPRi validation.

Potential beneficial effects of PD-1/PD-L1 blockade in Alzheimer's disease: A systematic review and meta-analysis of preclinical and clinical studies

This study reviews and analyzes preclinical and clinical studies on PD-1/PD-L1 blockade in Alzheimer's disease, finding potential benefits in reducing pathology and improving cognitive function.

Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimers Disease Pathologies in Neurons

This study shows that BMP signaling enhances APOE4-induced lipid metabolic dysfunctions in astrocytes, leading to increased neuronal tau phosphorylation and reduced survival.

Tau oligomer heterogeneity and associated protein profile in slowly versus rapidly progressive Alzheimer's disease

This study compares Tau oligomer properties in slowly and rapidly progressive Alzheimer's disease, finding distinct biochemical and proteomic profiles associated with different clinical progression rates.

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer's disease

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

Soluble epoxide hydrolase upregulation in Alzheimer's disease promotes blood-brain barrier dysfunction

This study shows that soluble epoxide hydrolase in astrocytes contributes to vascular instability in Alzheimer's disease, and its deletion reduces vascular amyloid burden and preserves vascular structure.

PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer's Disease Pathogenesis

This study shows that modulating PLD1 affects synaptic integrity and cognition in aging and Alzheimer's disease models, with PLD1 attenuation improving synaptic function and memory in AD mice.

Neuronal PARIS-STAT3 axis drives tau pathology and glial activation in Alzheimers disease

This study shows that PARIS in neurons activates STAT3, leading to tau pathology and glial activation in Alzheimer's disease, and identifies the PARIS-STAT3 pathway as a therapeutic target.

Restoring Amyloid Clearance via Astrocytes: Z17 Is a Selective Inhibitor of CHI3L1 in Alzheimers Disease

This paper identifies Z17 as a selective CHI3L1 inhibitor that restores astrocytic function and mitigates neuroinflammation in Alzheimer's disease.

A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus

This study uses a mouse model to show that early tau pathology in the entorhinal cortex induces morphological changes and neurogenic plasticity in the hippocampus without affecting synaptic strength.

Age-specific Aβ-Tau interactions underlie spatial memory deficits in an APP/PS1 amyloidosis model

This study examines how Aβ and tau interactions affect spatial memory in APP/PS1 mice, finding that memory decline is driven by combined Aβ and tau pathologies.