Alzheimer's disease research and treatments

Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology

The paper identifies stable neuronal representations in cognitively resilient Alzheimer's disease rats during repeated stimulation, suggesting a potential biomarker for cognitive resilience.

Pre-amyloid cognitive intervention preserves brain function in aged TgF344-AD rats, maintaining connectivity and enhancing plasticity in a sex-specific manner

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

Selective Inactivation of Astrocytic Monoacylglycerol Lipase for Alzheimer Disease Therapy

This study identifies astrocytic monoacylglycerol lipase (MAGL) as a therapeutic target for Alzheimer's disease, showing that its inactivation reduces pathology and improves cognition in transgenic mice.

Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer s disease

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

Integrative Gene Co-expression Network Analysis Reveals Protein-Coding and lncRNA Genes Associated with Alzheimer's Disease Pathology

The paper identifies protein-coding and lncRNA genes associated with Alzheimer's disease pathology through co-expression network analysis of brain RNA-seq data.

Pathological Mechanisms of Motor Dysfunction in Familial Danish Dementia: Insights from a Knock-In Rat Model

This study uses a FDD-KI rat model to show that vascular amyloid deposition, neuroinflammation, and white matter damage contribute to motor dysfunction in Familial Danish Dementia.

Probing tau citrullination in Alzheimer's disease brains and mouse models of tauopathy

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

G-quadruplex sequence dictates tau oligomerization and fibril morphology

This study shows that G-quadruplex sequences influence tau oligomerization and fibril morphology in human hippocampal aggregates.

N-Linked Glycosylation as a Driver of Tau Pathology and Neuronal Transmission

This study investigates how N-linked glycosylation affects Tau propagation and neuronal uptake by analyzing glycan site and structure effects on Tau-polyanion binding and seeding.

Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer's disease

This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.

Protective ApoE variants support neuronal function by extracting peroxidated lipids

The paper shows ApoE2 and ApoE3Ch variants protect neurons by removing toxic peroxidated lipids, while ApoE4 worsens lipid-induced damage in rodent models.

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction

This study examines how Tau35 protein affects lysosomal function and autophagy, identifying early pathological changes linked to neurotoxicity in tauopathies.

Post-translational modifications in the brain are critical contributors to Alzheimers disease neuropathology and cognitive decline

This study identifies novel post-translational modifications in Alzheimer's disease brains linked to neuropathology and cognition using mass spectrometry data from 101 participants.

Lipidomic Fingerprints Reveal Sex-, Age-, and Disease-Dependent Differences in the TgF344-AD Transgenic Rats

The paper identifies age, sex, and disease-dependent lipidomic changes in TgF344-AD rats, showing similarities to human lipid profiles and developing predictive models for AD.

Single-cell digital twins identify drug targets and repurposable medicine in Alzheimers disease

This study develops a single-cell digital twin framework to identify drug targets and repurposable medicines in Alzheimer's disease using single-nuclei RNA-seq and ATAC-seq data.

Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets

The paper identifies five therapeutic targets for Alzheimer's disease by integrating phenotypic and proteomic screening in murine microglial cells.

Structure-specific Mini-Prion Model for Alzheimer's Disease Tau Fibrils

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

PP2A methylesterase, PME-1, and PP2A methyltransferase, LCMT-1, control sensitivity to impairments caused by injury-related oligomeric tau

The paper investigates how PP2A regulators LCMT-1 and PME-1 affect sensitivity to tau-induced impairments in models of neurodegenerative diseases.

Single Cell Landscape of Sex-specific Drivers of Alzheimers Disease

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

Alternative Anastrozole Target CYP4V2 Impairs Neurons in Preclinical Models of Inherited Tauopathy

This study identifies anastrozole's off-target CYP4V2 as a neuroprotective factor in tauopathy models by reducing Tau phosphorylation and oxidative stress.

Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer's Disease (AD)

This study uses multi-region spatial transcriptomics to identify region-specific transcriptional responses to Aβ plaques in AD, revealing differences in neuronal vulnerability and molecular pathways.

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

This study shows that transplanting GABAergic interneuron progenitors restores slow oscillation rhythms in Alzheimer's disease mouse models.

Amyloid-β 42-carrying extracellular vesicles are associated with neurodegeneration and neuroinflammation in Alzheimer's disease

This study identifies Aβ42-carrying extracellular vesicles in plasma as biomarkers associated with neurodegeneration and neuroinflammation in Alzheimer's disease.

Proteomic analysis in Alzheimer's disease with psychosis reveals a shared AD proteomic landscape and a separate molecular signature of postsynaptic density disruption

This study identifies a shared proteomic profile in Alzheimer's disease with and without psychosis and a separate molecular signature linked to postsynaptic density disruption.

Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimers disease progression

This study identifies sex-dependent and progressive proteomic changes in the amygdala across Alzheimer's disease stages, revealing potential sex-specific biomarkers and therapeutic targets.

Neurotrophic Factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's Disease mice

This paper investigates the effects of NF-1/CPE gene therapy in AD mice, finding it prevents memory loss and reverses pathology by modulating protein networks involved in synaptogenesis, autophagy, and tau/Aβ accumulation.

The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neurons

This study shows OTULIN regulates tau expression and RNA metabolism in neurons, with implications for Alzheimer's disease and tauopathies.

Oligodendrocytes show enriched expression of amyloid precursor protein and GABA B receptor isoform 1a

The paper shows GABABR1a is most expressed in oligodendrocytes and APP is most expressed in oligodendrocytes among five brain cell types.